A5018801019- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Nanocluster Synthesis and Applications
- Epigenetics and DNA Methylation
- Bariatric Surgery and Outcomes
- Land Use and Ecosystem Services
- Simulation and Modeling Applications
- Circular RNAs in diseases
- Pregnancy-related medical research
- Metabolomics and Mass Spectrometry Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Fluid Dynamics and Turbulent Flows
- Advanced Computational Techniques and Applications
- Educational Reforms and Innovations
- Medicinal plant effects and applications
- Cancer-related molecular mechanisms research
- Genetic Syndromes and Imprinting
- Meat and Animal Product Quality
- Wind Energy Research and Development
- Environmental and Agricultural Sciences
- Electrochemical sensors and biosensors
- Advanced Sensor and Control Systems
Central China Normal University
2023-2024
Northeast Normal University
2023-2024
Ministry of Education of the People's Republic of China
2023-2024
Inner Mongolia People's Hospital
2021-2024
Northwell Health
2024
Peking University First Hospital
2015-2023
Peking University
2014-2023
Beijing Chao-Yang Hospital
2023
Capital Medical University
2023
Jilin Agricultural University
2022
Anaemia in pregnant women is a public health problem, especially developing countries. The aim of this study was to assess the prevalence and related risk factors anaemia during pregnancy large multicentre retrospective (n = 44,002) determine adverse outcomes with or without anaemia. secondary data analysis named "Gestational diabetes mellitus Prevalence Survey (GPS) China". Structured questionnaires were used collect socio-demographic characteristics, haemoglobin levels from all...
Developing highly active and selective advanced nanozymes for enzyme-mimicking catalysis remains a long-standing challenge basic research practical applications. Herein, we grafted chiral histidine- (His-) coordinated copper core onto Zr-based metal–organic framework (MOF) backbones to structurally mirror the bimetal site of natural catechol oxidase. Such biomimetic fabricated process affords MOF-His-Cu with oxidase-like activity, which can catalyze dehydrogenation oxidation o-diphenols then...
Neurotoxicity of organophosphate compounds (OPs) can catastrophically cause nervous system injury by inhibiting acetylcholinesterase (AChE) expression. Although artificial systems have been developed for indirect neuroprotection, they are limited to dissociating P-O bonds eliminating OPs. However, these failed overcome the deactivation AChE. Herein, we report our finding that Al3+ is engineered onto nodes metal-organic framework synthesize MOF-808-Al with enhanced Lewis acidity. The...
The tris(bipyridine)ruthenium(II) (Ru(bpy)32+)–tripropylamine anodic electrochemiluminescence (ECL) system has been widely applied in commercial bioanalysis. However, the presence of amine compounds biological environment results unavoidable interference signals, which hinder further extensive use system. In contrast, cathodic Ru(bpy)32+ ECL can overcome these limitations. Ru(bpy)32+/peroxydisulfate (S2O82–, PDS) extensively employed due to its ability produce a sulfate radical anion (SO4•–)...
Abstract Semiconductor‐based photoelectrochemical (PEC) fuel cells offer a feasible solution for sustainable and environmentally friendly energy production by converting solar chemical into electrical energy. However, the low PEC activities of have hindered their practical application due to rapid electron‐hole recombination slow interfacial reaction kinetics. To address this issue, unique cell composed dual photoelectrodes utilizing low‐cost biomass, ascorbic acid, as an organic is...
The unsatisfactory catalytic activity of nanozymes owing to their inefficient electron transfer (ET) is the major challenge in biomimetic catalysis-related biomedical applications. Inspired by photoelectron transfers natural photoenzymes, we herein report a photonanozyme single-atom Ru anchored on metal-organic frameworks (UiO-67-Ru) for achieving photoenhanced peroxidase (POD)-like activity. We demonstrate that atomically dispersed sites can realize high photoelectric conversion efficiency,...
Engineering isolated metal sites resembling the primary coordination sphere of metallocofactors enables atomically dispersed materials as promising nanozymes. However, most existing nanozymes primarily focus on replicating specific while neglecting other supporting cofactors within active pockets, leading to reduced electron transfer (ET) efficiency and thus inferior catalytic performances. Herein, we report a metal-organic framework UiO-67 nanozyme with iron sites, which involves multiple...
Abstract Engineering isolated metal sites resembling the primary coordination sphere of metallocofactors enables atomically dispersed materials as promising nanozymes. However, most existing nanozymes primarily focus on replicating specific while neglecting other supporting cofactors within active pockets, leading to reduced electron transfer (ET) efficiency and thus inferior catalytic performances. Herein, we report a metal–organic framework UiO‐67 nanozyme with iron sites, which involves...
Abstract Defect engineering is an effective strategy to enhance the enzyme‐like activity of nanozymes. However, previous efforts have primarily focused on introducing defects via de novo synthesis and post‐synthetic treatment, overlooking dynamic evolution during catalytic process involving highly reactive oxygen species. Herein, a defect‐engineered metal–organic framework (MOF) nanozyme with mixed linkers reported. Over twofold peroxidase (POD)‐like enhancement compared unmodified...
Gestational diabetes mellitus (GDM) is associated with both short- and long-term adverse health consequences for the mother her offspring. The aim was to study prevalence risk factors GDM in Beijing.The population consisted of 15,194 pregnant women attending prenatal care 15 hospitals Beijing, who delivered between June 20, 2013, November 30, after 28 weeks gestation. participants were selected by cluster sampling from identified through random systematic based on number deliveries 2012. A...
Objective Macrosomia is one of the most common complications in gestational diabetes mellitus. Insulin-like growth factor 2 and H19 are two imprinted candidate genes that involved fetal development. Change methylation at differentially methylated region insulin-like has been proved to be an early event related programming metabolic profile, including macrosomia small for age offspring. Here we hypothesize alteration associated with induced by intrauterine hyperglycemia. Results The...
Insulin resistance (IR) is a critical factor of the pathophysiology Gestational diabetes mellitus (GDM). Studies on key organs involved in IR, such as livers and adipose tissues, showed that Toll-like receptor 4 (TLR4) can regulate insulin sensitivity. As maternal-fetal interface with multi-functions, placentae could contribute to development IR for GDM. Thus, we investigated expressions TLR4/Myeloid Differentiation 88 (MyD88)/Nuclear Factor kappa-light-chain-enhancer activated B cells...
Hemoglobin (Hb) measurement is a standard test among pregnant women during the first perinatal visit that used to evaluate physical status and anemia. However, studies focusing on Hb levels pregnancy outcomes are scarce. This study aimed determine whether in early were associated with risk of gestational diabetes mellitus (GDM), pre-eclampsia (PE) preterm birth. A hospital-based retrospective was conducted 21,577 singleton, non-smoking pregnancies between June 2013 January 2015. The...
Abstract Various applications lead to the requirement of nanozymes with either specific activity or multiple enzyme‐like activities. To this end, intelligent freely switching specificity abilities hold great promise adapt complicated and changeable practical conditions. Herein, a nitrogen‐doped carbon‐supported copper single‐atom nanozyme (named Cu SA/NC) switchable is reported. Atomically dispersed active sites endow SA/NC peroxidase‐like at room temperature. Furthermore, intrinsic...
The study aimed to evaluate whether exercise intervention can be applied pregnant women with gestational diabetes mellitus (GDM) for controlling weight gain (GWG) and combating GDM-related outcomes. Retrospective six months analysis of 14,168 single without from 15 hospitals in Beijing 2013. Each participant's demographic data, interventions condition medical information were collected individually by questionnaires relying on records. level statistical significance was set equal 0.05. 2750...
Disturbances in maternal lipid metabolism have been shown to increase the risk of adverse pregnancy outcomes. However, there is no consensus as what constitutes normal values during pregnancy. Thus, aim this study was establish serum reference ranges early and middle pregnancy.We conducted a retrospective survey Beijing from 2013 2014. A total 17,610 singleton pregnancies with data were included. First, after excluding women outcomes, we performed descriptive analysis cholesterol (TC),...
This study aimed at evaluating the predictive effects of early pregnancy lipid profiles and fasting glucose on risk gestational diabetes mellitus (GDM) in patients stratified by prepregnancy body mass index (p-BMI) to determine optimal cut-off values each indicator for different p-BMI ranges. A retrospective system cluster sampling survey was conducted Beijing during 2013 a total 5,265 singleton pregnancies without were included. The information participant collected individually using...
Background: Hyperglycemia is associated with adverse pregnancy outcomes. However, the relationships between them remain ambiguous. This study aimed to analyze effect of different oral glucose tolerance test (OGTT) results on perinatal Methods: retrospective cohort included data from 15 hospitals in Beijing June 20, 2013 November 30, 2013. Women gestational diabetes mellitus (GDM) were categorized according number and distribution abnormal OGTT values, characteristics outcomes evaluated....
Abstract Background This study aimed to investigate the association between maternal insulin resistance (IR) in late second trimester and pregnancy outcomes, as well identify risk factors of IR among women with gestational diabetes mellitus (GDM). Methods A retrospective was conducted 2647 diagnosed GDM. evaluated using homeostasis model assessment method for (HOMA‐IR) (between 24 28 weeks), lipid profiles were measured at same time. Patients divided into groups based on quartiles HOMA‐IR....