Jonathan Chien
A5049026257- Neural dynamics and brain function
- Circadian rhythm and melatonin
- Memory and Neural Mechanisms
- Diabetes and associated disorders
- Disaster Response and Management
- Neural and Behavioral Psychology Studies
- COVID-19 epidemiological studies
- Neurobiology and Insect Physiology Research
- Neuroendocrine regulation and behavior
- COVID-19 and Mental Health
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Kawasaki Disease and Coronary Complications
- Long-Term Effects of COVID-19
- Animal Behavior and Reproduction
- Systemic Lupus Erythematosus Research
- Photoreceptor and optogenetics research
New York University
2022-2024
Icahn School of Medicine at Mount Sinai
2020-2023
Allen Institute for Brain Science
2022-2023
McGill University
2022
Abstract Post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are debilitating, clinically heterogeneous and unknown molecular etiology. A transcriptome-wide investigation was performed in 165 acutely infected hospitalized individuals who were followed into the post-acute period. Distinct gene expression signatures already present whole blood during infection, with innate adaptive immune cells implicated different symptoms. Two clusters exhibited...
Multisystem inflammatory syndrome in children (MIS-C) presents with fever, inflammation and pathology of multiple organs individuals under 21 years age the weeks following severe acute respiratory coronavirus 2 (SARS-CoV-2) infection. Although an autoimmune pathogenesis has been proposed, genes, pathways cell types causal to this new disease remain unknown. Here we perform RNA sequencing blood from patients MIS-C controls find disease-associated genes clustered a co-expression module annotated CD56
Abstract Introduction Severe COVID-19 leads to important changes in circulating immune-related proteins. To date it has been difficult understand their temporal relationship and identify cytokines that are drivers of severe outcomes underlie differences between sexes. Here, we measured 147 proteins during acute investigate these questions. Methods We protein abundances using the SOMAscan nucleic acid aptamer panel two large independent hospital-based cohorts Canada United States. fit...
Summary Sexual and aggressive behaviors are two evolutionarily conserved social vital for an animal’s survival reproductive success. While increasing number of brain regions in the limbic system have been identified as functionally relevant these types behaviors, understanding how cues represented across generated via this network activity remains elusive. To gain a holistic view neural responses during we utilized multi-fiber photometry to simultaneously record Ca 2+ signals estrogen...
The anterior cingulate cortex (ACC) is believed to be involved in many cognitive processes, including linking goals actions and tracking decision-relevant contextual information. ACC neurons robustly encode expected outcomes, but how this relates putative functions of remains unknown. Here, we approach question from the perspective population codes by analyzing neural spiking data ventral dorsal banks two male monkeys trained perform a stimulus-motor mapping task earn rewards or avoid...
Abstract Objective. Distributed hypothalamic-midbrain neural circuits help orchestrate complex behavioral responses during social interactions. Given rapid advances in optical imaging, it is a fundamental question how population-averaged activity measured by multi-fiber photometry (MFP) for calcium fluorescence signals correlates with behaviors question. This paper aims to investigate the correspondence between MFP data and behaviors. Approach: We propose state-space analysis framework...
Distributed hypothalamic-midbrain neural circuits orchestrate complex behavioral responses during social interactions. How population-averaged activity measured by multi-fiber photometry (MFP) for calcium fluorescence signals correlates with behaviors is a fundamental question. We propose state-space analysis framework to characterize mouse MFP data based on dynamic latent variable models, which include continuous-state linear dynamical system (LDS) and discrete-state hidden semi-Markov...
Abstract The anterior cingulate cortex (ACC) is believed to be involved in many cognitive processes, including linking goals actions and tracking decision-relevant contextual information. ACC neurons robustly encode expected outcomes, but how this relates putative functions of remains unknown. Here, we approach question from the perspective population codes by analyzing neural spiking data ventral dorsal banks monkeys trained perform a stimulus-motor mapping task. We found that populations...