A5018031933- 3D Printing in Biomedical Research
- Microfluidic and Capillary Electrophoresis Applications
- Microfluidic and Bio-sensing Technologies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Neuroscience and Neural Engineering
- Coronary Interventions and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Traditional Chinese Medicine Studies
- Liver physiology and pathology
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Nanopore and Nanochannel Transport Studies
- Monoclonal and Polyclonal Antibodies Research
- Muscle Physiology and Disorders
- Electrospun Nanofibers in Biomedical Applications
- Pancreatic function and diabetes
- Alcohol Consumption and Health Effects
- Advanced Sensor and Energy Harvesting Materials
- Blood properties and coagulation
- Alzheimer's disease research and treatments
- Cardiac Valve Diseases and Treatments
- Computational Drug Discovery Methods
- Genetics, Aging, and Longevity in Model Organisms
- Angiogenesis and VEGF in Cancer
Shenzhen Second People's Hospital
2018-2024
Southern Medical University
2021-2022
Jinan University
2018-2021
Shenzhen University Health Science Center
2020
Dalian University
2016-2018
Dalian University of Technology
2016-2018
The poor metabolic ability of cell lines fails to meet the requirements an in vitro model for drug interaction testing which is crucial development or clinical application drugs. Herein, we describe a liver sinusoid-on-a-chip device composed four kinds transformed (HepG2 cells, LX-2 EAhy926 and U937 cells) that were ordered physiological distribution with artificial blood flow biliary efflux flowing opposite direction. This microfluidic applied three-dimensional culturing HepG2 cells high...
To investigate the potential active compounds and underlying mechanisms of Paeonia lactiflora Pall. (PLP) on treatment Alzheimer's disease (AD) based network pharmacology.The components PLP were collected from Traditional Chinese Medicine System Pharmacology (TCMSP) database, their possible target proteins predicted using TCMSP, SwissTargetPrediction, STITCH databases. The putative AD-related identified Therapeutic Target Database (TTD), GeneCards, MalaCards database. compound-target-disease...
The intracellular calcium dynamics in vascular endothelial cells (VECs) response to wall shear stress (WSS) and/or adenosine triphosphate (ATP) have been commonly regarded as an important factor regulating VEC function and behavior including proliferation, migration apoptosis. However, the effects of time-varying ATP signals usually neglected past investigations field mechanobiology. In order investigate combined WSS dynamic on VECs, a Y-shaped microfluidic device, which can provide cultured...
Carcinoembryonic antigen (CEA) is a broad-spectrum tumor marker used in clinical applications. The primarily method for measuring CEA based on chemiluminescence serum during enzyme-linked immunosorbent assays (ELISA) 96-well plates. However, this multi-step process requires large and expensive instruments, takes long time. In study, high-throughput centrifugal microfluidic device was developed detecting without the need cumbersome washing steps normally immunoreactions. This microdevice...
Abstract: Organ-on-a-chip systems integrate microengineering, microfluidics, and biomimetic principles to create bionic for organ-level physiological simulation, disease research, drug screening. Despite the limitations of cell sources, novel materials, high-sensitivity detection equipment, various organ-on-a-chip have been developed evaluation toxicity in vitro. They show an unparalleled capacity bridge gap between preclinical clinical outcomes, as well improve predictability toxicity. In...
During electrospinning, the fibers deposited on collector are usually randomly oriented in a disordered form. Researchers hope to generate periodic structures expand application of including improving sensing properties electronic and photonic devices, mechanical solid polymer composites directional growth human tissues. Here, we propose technique control preparation aligned foodborne nanofibers by placing dielectric polymers microfluidic which does not require use metal collectors. This...
The intracellular calcium dynamics in vascular endothelial cells (VECs) response to wall shear stress (WSS) and/or adenosine triphosphate (ATP) have been commonly regarded as an important factor regulating VEC function and behavior including proliferation, migration apoptosis. However, the effects of time-varying ATP signals usually neglected past investigations field mechanobiology. In order investigate combined WSS dynamic on VECs, a Y-shaped microfluidic device, which can provide cultured...
Abstract A microfluidic array was constructed for trapping single cell and loading identical dynamic biochemical stimulation gain a better understanding of Ca2+ signaling at resolution in the present study. This consists multiple radially aligned flow channels with equal intersection angles, which designed by combination stagnation point physical barrier. Numerical simulation results trajectory analysis have shown effectiveness this device. Fluorescent experiment demonstrated effects rate...
Investigating the intracellular dynamics response to spatio-temporal environmental stimuli which cells are exposed can provide insights into signal transduction pathways and regulation mechanisms of cellular functions. Microfluidics has become an effective platform for precise control microenvironment, high-throughput, automatic analysis dynamic process. In this study, a novel microfluidic-based system been designed, includes peripheral fluid driving microfluidic chip with variable...
A radial microfluidic array is proposed to analyze intracellular calcium dynamics in response dynamic extracellular adenosine triphosphate (ATP) stimulation at single cell level. The consists of multiple trapping units distribution with same angle, each unit designed by a combination stagnation point flow and physical barrier. Cellular experimental results verified that the effectiveness behaviors static or ATP stimulation.