A5049870731- Gun Ownership and Violence Research
- Renal and related cancers
- Suicide and Self-Harm Studies
- CRISPR and Genetic Engineering
- Neonatal Respiratory Health Research
- Hernia repair and management
- Microbial infections and disease research
- Intestinal Malrotation and Obstruction Disorders
- Intestinal and Peritoneal Adhesions
- Infant Nutrition and Health
- Prenatal Screening and Diagnostics
- Birth, Development, and Health
- Injury Epidemiology and Prevention
- Homicide, Infanticide, and Child Abuse
- Urological Disorders and Treatments
- Viral gastroenteritis research and epidemiology
- Renal cell carcinoma treatment
- Pluripotent Stem Cells Research
- Hemoglobinopathies and Related Disorders
- Poxvirus research and outbreaks
- Genetic Syndromes and Imprinting
- Bacillus and Francisella bacterial research
- Sports Performance and Training
- Hematopoietic Stem Cell Transplantation
- Crime Patterns and Interventions
University of Michigan–Ann Arbor
2022-2024
National Center for Injury Prevention and Control
2024
DermSurgery Associates
2024
C. S. Mott Children's Hospital
2023-2024
Children's Hospital of Philadelphia
2018-2021
Temple University
2020
University of Pennsylvania
2020
Cincinnati Children's Hospital Medical Center
2007
Boston Children's Hospital
2006
University of Connecticut
1964
Prenatal CRISPR gene editing results in efficient pulmonary epithelial cell and ameliorates a mouse model of congenital lung disease.
In utero base editing has the potential to correct disease-causing mutations before onset of pathology. Mucopolysaccharidosis type I (MPS-IH, Hurler syndrome) is a lysosomal storage disease (LSD) affecting multiple organs, often leading early postnatal cardiopulmonary demise. We assessed in adeno-associated virus serotype 9 (AAV9) delivery an adenine editor (ABE) targeting Idua G→A (W392X) mutation MPS-IH mouse, corresponding common IDUA (W402X) patients. Here we show efficient long-term...
Abstract Background The pygopus gene of Drosophila encodes an essential component the Armadillo (β-catenin) transcription factor complex canonical Wnt signaling. To better understand functions Pygopus -mediated signaling in kidney development, targeted mutations were made two mammalian orthologs, Pygo1 and Pygo2 . Results Each mutation deleted >80% coding sequence, including critical PHD domain, almost certainly resulted null function. homozygous mutants, with rare exception, died shortly...
There are no comprehensive management guidelines for pediatric blunt renal injury; therefore, we hypothesized that wide variation in care exists. We sought to describe contemporary of trauma and explore associations between clinical strategies adverse outcomes. retrospectively evaluated injury patients (younger than 18 years) treated at 11 level I centers from 2020 2022. categorized by the American Association Surgery Trauma grade (low, grades 1-3; high, 4-5) isolated versus polytrauma....
Abstract The Lim1 gene has essential functions during several stages of kidney development. In particular, a tissue‐specific knockout in the early metanephric mesenchyme results formation earliest nephron precursor, renal vesicle, but failure this structure to progress next stage, comma‐shaped body. To better understand molecular nature developmental arrest, we used laser capture microdissection–microarray strategy examine perturbed expression pattern mutant vesicles. Among genes found...
Firearm suicides among adolescents have increased in the US and rates vary across racial ethnic groups. In this study, we examined contextual information around adolescent firearm analyzed how incident characteristics We (ages 10–18 years) from 2004 to 2020 using data National Fatality Review-Case Reporting System (NFR-CRS). There were 4,153 during that period. Suicides often involved males, older (15–18 years), handguns. Most firearms belonged primary caregiver incidents frequently occurred...
Abstract In utero hematopoietic cell transplantation (IUHCT) is a nonmyeloablative nonimmunosuppressive alternative to postnatal stem for the treatment of congenital hemoglobinopathies. Anti-HLA donor-specific Abs (DSA) are associated with high incidence graft rejection following transplantation. We determine if DSA present in mother can similarly cause fetus IUHCT. Ten million C57BL/6 (B6, H2kb) bone marrow cells were transplanted into gestational day 14 BALB/c (H2kd) fetuses. The pregnant...
<b><i>Background:</i></b> In an effort to mitigate the major morbidities and mortality associated with extreme prematurity, we have developed EXTrauterine Environment for Neonatal Development (EXTEND) designed provide physiologic support of extremely premature infants. <b><i>Objectives:</i></b> We previously shown that long-term, fetal lambs is possible EXTEND, but in this study, sought demonstrate bioenergetic equipoise at tissue level....
Congenital tracheo-esophageal fistula/esophageal atresia (TEF/EA) with concomitant pulmonary agenesis is exceedingly rare and has a high mortality rate. While there are several reported cases of successful repair, all but one patient had right-sided agenesis. In the case left-sided agenesis, incomplete underwent repair through left thoracotomy. We present first TEF/EA complete This also elective pre-operative veno-venous extracorporeal membrane oxygenation (ECMO) subsequent TEF/EA. discuss...
Abstract Introduction Necrotizing enterocolitis (NEC) causes significant neonatal morbidity. A subset of infants experience precipitous decline and death from fulminant-NEC (F-NEC). We sought to determine the effect feeding practices on development this more virulent form NEC. Materials Methods Premature neonates developing Bell's stage II or III NEC between May 2011 June 2017 were reviewed. Infants stratified as having F-NEC, defined NEC-totalis causing rapid within 72 hours. Risk factors...
Contextual factors that contribute to firearm injuries among children aged 0 10 are not well understood.