A5067442281- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Thermoregulation and physiological responses
- Gold and Silver Nanoparticles Synthesis and Applications
- Optical Imaging and Spectroscopy Techniques
- Advanced Fluorescence Microscopy Techniques
- Advanced X-ray Imaging Techniques
- Dermatology and Skin Diseases
- Advanced biosensing and bioanalysis techniques
- X-ray Spectroscopy and Fluorescence Analysis
- Optical Coherence Tomography Applications
- Impact of Technology on Adolescents
- Education and Learning Interventions
- Healthcare Education and Workforce Issues
- 3D Shape Modeling and Analysis
- Photodynamic Therapy Research Studies
- Spondyloarthritis Studies and Treatments
- Skin Protection and Aging
- Digital Mental Health Interventions
- Optical Polarization and Ellipsometry
- RNA Interference and Gene Delivery
- Exercise and Physiological Responses
- Bee Products Chemical Analysis
- Biosensors and Analytical Detection
- Advanced Electron Microscopy Techniques and Applications
Korea National University of Transportation
2024
Chungbuk Provincial College
2015-2024
University of Pittsburgh Medical Center
2010-2015
University of Pittsburgh
2010-2012
Korea University
2004-2010
Korea University Medical Center
2008-2010
Hanyang University
2007
Surface-enhanced Raman scattering (SERS) imaging has been used for the targeting and of specific cancer markers in live cells. For this purpose, Au/Ag core−shell nanoparticles, conjugated with monoclonal antibodies, were prepared. The procedures to label cells those bimetallic nanoprobes have developed highly sensitive SERS In present study, HEK293 expressing PLCγ1 as optical target. Our results demonstrate potential feasibility technology biomarkers
Tumor recognition: Conjugation of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) with the cyclic pentapeptide c(RGDYK) and subsequent complexation GdCl3⋅6 H2O afforded Gd-DOTA-RGD, which, although a single molecular entity, is an efficient, target-specific MRI contrast agent for ανβ3 receptors in hepatocellular carcinoma H-ras12V transgenic mice. The compound displays very low cytotoxicity might hence warrant further study clinical usage.
In vitro cell experiments have been performed to detect and monitor the upregulation of intercellular adhesion molecule-1 (ICAM-1) E-selectin simultaneously by photoacoustic molecular imaging (PMI).Human umbilical vein endothelial cells (HUVECs) were grown on gelatincoated glass slides stimulated with inflammatory cytokines induce expression biomarkers, ICAM-1 E-selectin.Gold nanorods (GNRs) aspect ratio (AR) 1:3 absorption centered at 715 nm conjugated anti-ICAM-1 antibody GNRs AR 1:3.5 800...
A new light illumination scheme to increase imaging depth in photoacoustic (PA) was designed and evaluated by silico simulations tested vitro experiments.A relatively large portion of the energy shining into body a human reflects off skin surfaces.Collecting reflected redirecting it onto surfaces will effective input energy, resulting an penetration for same source.Its performance PA using finite element (FE)-based numerical simulation model composed four modules.In experiments with catcher,...
A finite element (FE)-based simulation model for photoacoustic (PA) has been developed incorporating light propagation, PA signal generation, and sound wave propagation in soft tissues using a commercial FE package, COMSOL Multiphysics. The is evaluated by comparing with other known models such as Monte Carlo method heat-pressure model. In this silico simulation, composed of three parts 1) homogeneous background submerged water, 2) target tissue inclusion (or contrast agents), 3) short...
Multi-modality imaging is beneficial for both preclinical and clinical applications as it enables complementary information from each modality to be obtained in a single procedure. In this paper, we report the design, fabrication, testing of novel tri-modal vivo system exploit molecular/functional fluorescence (FL) photoacoustic (PA) well anatomical ultrasound (US) imaging. The same transducer was used US PA imaging, bringing pulsed laser light into compact probe by fiberoptic bundles. FL...
Abstract Onychomycosis, or fungal infection of the nail, is a disease seen frequently in clinical settings. However, rates positive identification using potassium hydroxide preparations cultures are relatively low. Precise diagnosis possible via histopathologic examination to monitor existence fungus and performance culture for confirmation. Phase‐contrast hard X‐ray microscopy synchrotron radiation provides 70‐nm spatial resolution enables imaging minute internal cellular structures. This...
Abstract: The severity of psoriasis has been traditionally assessed by measures, such as the area and index (PASI), scores, lesional scores. As a result, even experienced dermatologists show variations when attempting to determine psoriasis. Therefore, better non‐invasive objective measurement clinical signs is needed. In this study, an instrument, so‐called ‘stereoimage optical topometer’ (SOT), based on new concept ‘stereoimaging’ was used measure three‐dimensional skin surface. aim study...
The objective and quantitative assessment of the skin is important in medical cosmeceutical research. Assessment color an element for analyzing surface skin, which usually determined subjectively by a doctor or using analysis devices. These devices, however, cannot provide correct information because construed from mean value observation region, distribution impossible. purpose this paper to develop method permit measurement each pixel unit image analyze color.The Skin Color Distribution...
Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder that becoming increasingly prevalent. Experimental animal models have been an indispensable tool for studying its pathological mechanisms and in vivo testing of novel therapeutic approaches. AD-like lesions can be induced experimentally NC/Nga mice. Pedunculagin, ellagitannin purified from the Manchurian alder, Alnus hirsuta var. microphylla, Betulaceae, immunomodulator. To evaluate effect pedunculagin mice, using...
A new design of light illumination scheme for deep tissue photoacoustic (PA) imaging, a catcher, is proposed and evaluated by in silico simulation. Finite element (FE)-based numerical simulation model was developed imaging soft tissues. In this using commercially available FE package (COMSOL MultiphysicsTM, COMSOL Inc., USA), short-pulsed laser point source (pulse length 5 ns) placed water on the surface. Overall, four sets models were integrated together to describe physical principles PA...
In vitro cell experiments have been performed to detect the upregulation of ICAM-1 and E-selectin simultaneously by photoacoustics (PA). Human umbilical vein endothelial cells (HUVECs) were grown on gelatin-coated glass slides stimulated with inflammatory cytokines induce expression biomarkers E-selectin. Gold nanorods (GNR) aspect ratio (AR) 1:3 absorption centered at 715 nm conjugated anti-ICAM-1 antibody GNR AR 1:3.5 800 anti-E-Selectin exposed HUVECs different stimulation conditions. A...
The widespread adoption of the smartphone has led to both positive and negative consequences for adolescents’ mental health. This study examines interplay between dependence (SPD), generalized anxiety disorder (GAD), various health outcomes among Korean adolescents. Data from 16th Adolescence Health Behavior Survey (2020), including 54,948 middle high school students, were analyzed. Adolescents categorized into three groups based on SPD severity. GAD-7 scale assessed anxiety, other factors...
The purpose of this study is to propose critical thinking clinical judgment skills and strategies improve academic achievement which are required for understanding in integral manner further applying the nursing activities necessary patient care by running a simulation exercise focused on cases difficult patients, students could scarcely encounter directly their actual practices.
This study aims to develop a mobile game for auditory rehabilitation training targeted at individuals with hearing impairments.The was developed utilizing the contents of 'Meari' app, which in previous research, focus on stimulating interest and motivation continuous learning, as well enhancing language functions impairments.Specifically, includes an OX quiz, word survival designed train listening speaking facilitate treatment simultaneously.Moreover, it application intended offer anyone,...
Living skin for basic and clinical research can be evaluated by Confocal Laser Scanning Microscope (CLSM) non-invasively. CLSM imaging system achieve image its native state either "in vivo" or "fresh biopsy (ex vivo)" without fixation, sectioning staining that is necessary routine histology. This study examines the potential fluorescent with a various exogenous contrast agent, to provide more resolution images in skin. In addition, vivo researchers will extended range of application. The...
Here we report the preliminary study to evaluate potential of two hydrophilic and photostable quaterrylenediimide-cored dendrimers for photoacoustic (PA) imaging applications. These exhibit high PA signal intensity remarkable chemical photo stability.
In biomedical application study using phase contrast X-ray, both sample thickness or density and absorption difference are very important factors in aspects of enhancement. We present experimental evidence that synchrotron hard X-ray suitable for radiological imaging biological samples down to the cellular level. investigated potential refractive index radiology un-monochromatized X-rays cell tissue various diseases. Material had been adopted medical field, such as apoE knockout mouse...
The object of this study was to examine the potential fluorescent confocal laser scanning microscope (CLSM) with a various contrast agent, provide more resolution images for human skin and animal skin.