A5101955422- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Ion Transport and Channel Regulation
- Immune Response and Inflammation
- Coastal wetland ecosystem dynamics
- Adenosine and Purinergic Signaling
- Lichen and fungal ecology
- Marine and coastal plant biology
- Neuroscience and Neuropharmacology Research
- Eicosanoids and Hypertension Pharmacology
- RNA and protein synthesis mechanisms
- Plant-based Medicinal Research
- Dermatological and Skeletal Disorders
- Tracheal and airway disorders
- Computational Drug Discovery Methods
- Glycosylation and Glycoproteins Research
- Mesenchymal stem cell research
- MicroRNA in disease regulation
- Congenital heart defects research
- Immune cells in cancer
- Molecular Sensors and Ion Detection
- Fatty Acid Research and Health
- Trace Elements in Health
- Magnesium in Health and Disease
- Genetic and Kidney Cyst Diseases
National Institute of Neurological Disorders and Stroke
2018-2022
National Institutes of Health
2020-2022
Maastricht University
2021
Maastricht University Medical Centre
2016
Universidad Autónoma de Madrid
2012-2015
Instituto de Investigaciones Biomédicas Sols-Morreale
2012-2015
Consejo Superior de Investigaciones Científicas
2012-2014
Universidad de Los Lagos
2006-2008
Universidad de Navarra
2004
Mutation type, location, dominant-negative IKs reduction, and possibly loss of cyclic adenosine monophosphate (cAMP)-dependent stimulation via protein kinase A (PKA) influence the clinical severity long QT syndrome type 1 (LQT1). Given malignancy KCNQ1-p.A341V, we assessed whether mutations neighbouring p.A341V in S6 channel segment could also increase arrhythmic risk.Clinical genetic data were obtained from 1316 LQT1 patients [450 families, 166 unique KCNQ1 mutations, including 277...
Plasma membrane integrity is essential for cell life. Any major break on it immediately induces the death of affected cell. Different molecules were described as disrupting this structure and thus showing antitumor activity. We have previously defined that elisidepsin (Irvalec®, PM02734) inserts self-organizes in plasma tumor cells, inducing a rapid loss integrity, permeabilization necrotic death. Here we show that, sensitive HCT-116 colorectal all these effects are consequence interaction...
Abstract Mutations in genes encoding Na + /K ‐ATPase α1, α2, and α3 subunits cause a wide range of disabling neurological disorders, dysfunction may contribute to neuronal injury stroke dementia. To better understand the pathogenesis these diseases, it is important determine expression patterns different within brain among specific cell types. Using two available scRNA‐Seq databases from adult mouse nervous system, we examined mRNA isoforms α, β Fxyd at single‐cell level regions various...
The potassium channel Kv7.1 associates with the KCNE1 regulatory subunit to trigger cardiac I Ks currents. Although Kv7.1/KCNE1 complex has received much attention, subcellular compartment hosting assembly is subject of ongoing debate. Evidence suggests that forms either earlier in endoplasmic reticulum or directly at plasma membrane. and mutations, responsible for long QT syndromes, impair association traffic, thereby altering We found do not assemble first stages their biogenesis. Data...
Na+/K+-ATPase, which creates transmembrane electrochemical gradients by exchanging 3 Na+ for 2 K+, is central to the pathogenesis of neurological diseases such as alternating hemiplegia childhood. Although Na+/K+-ATPase has distinct ion binding sites I-III, difficulty distinguishing events at each site from others hinders kinetic study these transitions. Here, we show that in human α3 can be resolved using extracellular Na+-mediated transient currents. When constrained bind and release only...
Resumen: El proyecto MeTaEducArte, surgio tras una larga experiencia docente-artistica, en respuesta a intensa reflexion sobre la propia practica educativa, se detecto necesidad de aplicar diferentes metodos didacticos, funcion las demandas del nuevo tipo estudiantes que encontramos actualmente nuestras aulas, el contexto Formacion Profesorado los estudios Grado Infantil y Primaria, Universidad Autonoma Madrid. Asi, ano 2011, nace terminoMeTaEducArte,dando nombreal Proyecto Innovacion...