A5074753211- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Receptor Mechanisms and Signaling
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Reproductive Health and Technologies
- Assisted Reproductive Technology and Twin Pregnancy
- Semiconductor materials and devices
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Medical Imaging Techniques and Applications
- Ovarian function and disorders
- Neuroscience and Neural Engineering
- Demographic Trends and Gender Preferences
- Prenatal Screening and Diagnostics
Universitat de Barcelona
2014-2024
Hospital de Nens de Barcelona
2023-2024
Selecting the best embryo for transfer is key to success in assisted reproduction. The use of algorithms or artificial intelligence can already predict blastulation implantation with good results. However, ploidy predictions still rely on invasive techniques. Embryologists are essential, and improving their evaluation tools enhance clinical outcomes. This study analyzed 374 blastocysts from preimplantation genetic testing cycles. Embryos were cultured time-lapse incubators tested...
Abstract Aim The voltage‐gated Kv7.1 channel, in association with the regulatory subunit KCNE1, contributes to I Ks current heart. However, both proteins travel plasma membrane using different routes. While KCNE1 follows a classical Golgi‐mediated anterograde pathway, is located endoplasmic reticulum‐plasma junctions (ER‐PMjs), where it associates before being delivered membrane. Methods To characterize channel routing these spots we used wide repertoire of methodologies, such as protein...
The potassium channel Kv7.1 associates with the KCNE1 regulatory subunit to trigger cardiac I Ks currents. Although Kv7.1/KCNE1 complex has received much attention, subcellular compartment hosting assembly is subject of ongoing debate. Evidence suggests that forms either earlier in endoplasmic reticulum or directly at plasma membrane. and mutations, responsible for long QT syndromes, impair association traffic, thereby altering We found do not assemble first stages their biogenesis. Data...
Abstract The voltage-dependent potassium channel Kv1.3 participates in the immune response. is essential different cellular functions, such as proliferation, activation and apoptosis. Because aberrant expression of linked to autoimmune diseases, fine-tuning its function crucial for leukocyte physiology. Regulatory KCNE subunits are expressed system, KCNE4 specifically tightly regulates Kv1.3. modulates currents slowing activation, accelerating inactivation retaining at endoplasmic reticulum...
Voltage-dependent potassium (Kv) channels contribute to the excitability of nerves and muscles. In addition, Kv participates in several cell functions, including cycle progression proliferation. channel remodeling has been associated with neoplastic growth cancer. Kv7 are expressed blood vessels, they participate maintenance vascular tone implicated myocyte Although evidence links different types cancer, its expression tumors never studied. Endothelium-derived neoplasms range from indolent...
New social conditions and progress in ART have both contributed to the delay parenthood developed countries. While effects of maternal age been widely studied, paternal is poorly understood, there are no specific guides on techniques treat its deleterious effects. It known that an increase sperm DNA fragmentation (SDF) elderly men, new selection devices using microfluids developed. This study analyses 189 ICSI cycles with donor oocytes performed between January 2018 February 2022....
Abstract Study question Does humidity have an impact on top-quality blastocyst rate, ploidy, live birth sex ratio and clinical outcomes? Summary answer Humid culture conditions in time-lapse incubators may enhance outcomes, particularly autologous cycles, without biasing euploidy or newborn sex. What is known already Recent advances assisted reproductive technology focused improving embryo are becoming more sophisticated. Although such as oxygen temperature well-studied, the optimal level...