A5039397301- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Receptor Mechanisms and Signaling
- Viral Infections and Immunology Research
- Nicotinic Acetylcholine Receptors Study
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Potassium and Related Disorders
- Blood disorders and treatments
- Cellular transport and secretion
- Synthesis and Biological Evaluation
Universitat de Barcelona
2019-2024
Introduction Kv1.3 is the main voltage-gated potassium channel of leukocytes from both innate and adaptive immune systems. Channel function required for common processes such as Ca2+ signaling but also cell-specific events. In this context, alterations in are associated with multiple disorders. Excessive activity correlates numerous autoimmune diseases, while reduced currents result increased cancer prevalence immunodeficiencies.
The voltage-dependent potassium channel Kv1.3 is a promising therapeutic target for the treatment of autoimmune and chronic inflammatory disorders. blockers are effective in treating multiple sclerosis (fampridine) psoriasis (dalazatide). However, most pharmacological antagonists not specific enough, triggering potential side effects limiting their use. Functional Kv oligomeric complexes which presence ancillary subunits shapes function pharmacology. In leukocytes, associates with KCNE4,...
Abstract The voltage-dependent potassium channel Kv1.3 plays essential roles in the immune system, participating leukocyte activation, proliferation and apoptosis. regulatory subunit KCNE4 acts as an ancillary peptide of Kv1.3, modulates K + currents controls abundance at cell surface. KCNE4-dependent regulation oligomeric complex fine-tunes physiological role Kv1.3. Thus, is crucial for Ca 2+ -dependent Kv1.3-related functions. To better understand we manipulated its expression various...
Abstract The voltage-dependent potassium channel Kv1.3 participates in the immune response. is essential different cellular functions, such as proliferation, activation and apoptosis. Because aberrant expression of linked to autoimmune diseases, fine-tuning its function crucial for leukocyte physiology. Regulatory KCNE subunits are expressed system, KCNE4 specifically tightly regulates Kv1.3. modulates currents slowing activation, accelerating inactivation retaining at endoplasmic reticulum...
The voltage-gated potassium channel Kv1.3 plays a crucial role during the immune response. forms oligomeric complexes by associating with several modulatory subunits. KCNE4, one of five members KCNE family, binds to Kv1.3, altering activity and membrane expression. association KCNEs Kv channels is subject numerous studies, stoichiometry such associations has led an ongoing debate. number KCNE4 subunits that can interact modulate unknown. transfers important elements channelosome negatively...
The voltage-gated potassium channel Kv1.3 plays a crucial role in the immune system response. In leukocytes, is co-expressed with dominant negative regulatory subunit KCNE4, which associates to trigger intracellular retention and accelerate C-type inactivation of channel. Previous research has demonstrated that main association between these proteins occurs through both COOH-termini. However, data fail fully elucidate KCNE4-dependent modulation kinetics. present study, we analyzed...