A5041925583- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Cellular transport and secretion
- Viral Infections and Immunology Research
- Nicotinic Acetylcholine Receptors Study
- Caveolin-1 and cellular processes
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Monoclonal and Polyclonal Antibodies Research
- Toxin Mechanisms and Immunotoxins
- Potassium and Related Disorders
Universitat de Barcelona
2015-2024
Abstract Aim The voltage‐gated Kv7.1 channel, in association with the regulatory subunit KCNE1, contributes to I Ks current heart. However, both proteins travel plasma membrane using different routes. While KCNE1 follows a classical Golgi‐mediated anterograde pathway, is located endoplasmic reticulum‐plasma junctions (ER‐PMjs), where it associates before being delivered membrane. Methods To characterize channel routing these spots we used wide repertoire of methodologies, such as protein...
Abstract The voltage-dependent potassium channel Kv1.3 plays essential roles in the immune system, participating leukocyte activation, proliferation and apoptosis. regulatory subunit KCNE4 acts as an ancillary peptide of Kv1.3, modulates K + currents controls abundance at cell surface. KCNE4-dependent regulation oligomeric complex fine-tunes physiological role Kv1.3. Thus, is crucial for Ca 2+ -dependent Kv1.3-related functions. To better understand we manipulated its expression various...
The voltage-dependent potassium (Kv) channel Kvβ family was the first identified group of modulators Kv channels. regulation α-subunits, in addition to their aldoketoreductase activity, has been under extensive study. However, scarce information about specific α-subunit-independent biology is available. expression Kvβs ubiquitous and, similar channels, tightly regulated leukocytes. Although subunits exhibit cytosolic distribution, spatial localization, close contact with plasma membrane...
Formation of the immunological synapse (IS) is a key event during initiation an adaptive immune response to specific antigen. During this process, T cell and antigen presenting form stable contact that allows integrate both internal external stimuli in order decide whether activate. The threshold for activation depends on strength frequency calcium (Ca