A5028002716- Glioma Diagnosis and Treatment
- TGF-β signaling in diseases
- Renal and related cancers
- Cell Adhesion Molecules Research
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Spine and Intervertebral Disc Pathology
- Medical Imaging and Analysis
- Animal Genetics and Reproduction
- Immune Response and Inflammation
- Connective Tissue Growth Factor Research
- Ubiquitin and proteasome pathways
- Cancer, Stress, Anesthesia, and Immune Response
- Genetic factors in colorectal cancer
- Hedgehog Signaling Pathway Studies
- Virus-based gene therapy research
- Liver physiology and pathology
- Immune cells in cancer
- Sarcoma Diagnosis and Treatment
- interferon and immune responses
- Cancer Research and Treatments
Centre Léon Bérard
2019-2024
Université Claude Bernard Lyon 1
2019-2024
Centre de Recherche en Cancérologie de Lyon
2019-2024
Centre National de la Recherche Scientifique
2019-2024
Inserm
2019-2024
Centro de Investigación del Cáncer
2024
Cancer Research Center
2024
Institut Jacques Monod
2023
Université Paris Cité
2023
Convergence
2023
TGF-β signaling is involved in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis, representing one of the four major pathways genetically altered 100% PDAC cases. exerts complex and pleiotropic effects cancers, notably via activation SMAD pathways, predominantly SMAD2/3/4. Though SMAD2 3 are rarely mutated SMAD4 lost about 50% PDAC, role SMAD2/3 a SMAD4-null context remains understudied. We herein provide evidence oncogenic effect response to TGF-β1 human cancer cells. report that...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is one of the solid tumors with poorest prognosis. The stroma this tumor abundant and composed extracellular matrix stromal cells (including cancer-associated fibroblasts immune cells). Nerve fibers invading represent a hallmark PDAC, involved in neural remodeling, which participates neuropathic pain, cancer cell dissemination relapse after surgery. remodeling regulated through functional interplays mediated by physical molecular interactions...
Pediatric diffuse midline gliomas (pDMG) are an aggressive type of childhood cancer with a fatal outcome. Their major epigenetic determinism has become clear, notably the identification K27M mutations in histone H3. However, synergistic oncogenic mechanisms that induce and maintain tumor cell phenotype have yet to be deciphered. In 20 30% cases, these tumors altered BMP signaling pathway mutation on I receptor ALK2, encoded by ACVR1 . potential impact non-mutated for is less clear. By...
ABSTRACT Rhabdomyosarcoma (RMS) is the most frequent form of paediatric soft-tissue sarcoma and remains a medical challenge, holding in failure current therapeutic strategies. RMS shares histological features with cells muscle lineage this cancer thought to arise from malignant transformation myogenic precursors. It has been proposed that myogenesis could represent “Jekyll Hyde” skeletal muscle. The underlying idea some early steps differentiation are blocked RMS, understanding how normal...
Toll-like receptor 3 (TLR3) is a pattern recognition mainly known for its role in innate immune response to infection. Indeed, binding of double-stranded RNA (dsRNA) TLR3 triggers pro-inflammatory cascade leading cytokine release and cell activation. Its anti-tumoral potential has emerged progressively, associated with direct impact on tumor death induction an indirect action system reactivation. Accordingly, agonists are currently being tested clinical trials several adult cancers....
Pediatric diffuse midline gliomas (pDMG) are an aggressive type of childhood cancer with a fatal outcome. Their major epigenetic determinism has become clear, notably the identification K27M mutations in histone H3. However, synergistic oncogenic mechanisms that induce and maintain tumor cell phenotype have yet to be deciphered. In 20 30% cases, these tumors altered BMP signaling pathway mutation on I receptor ALK2, encoded by ACVR1 . potential impact non-mutated for is less clear. By...
Recombination systems represent a major breakthrough in the field of genetic model engineering. The Flp recombinases (Flp, Flpe, and Flpo) bind cleave DNA Frt sites. We created transgenic mouse strain ([Fsp1-Flpo]) expressing Flpo recombinase fibroblasts. This was obtained by random insertion inside zygotes after pronuclear injection. expression placed under control promoter Fsp1 (fibroblast-specific protein 1) gene, whose starts gastrulation at Day 8.5 cells mesenchymal origin. verified...
Abstract Pediatric diffuse midline gliomas (pDMG) are an aggressive type of childhood cancer with a fatal outcome. Their major epigenetic determinism has become clear, notably the identification K27M mutations in histone H3. However, synergistic oncogenic mechanisms that induce and maintain tumor cell phenotype have yet to be deciphered. In 20 30% cases, these tumors altered BMP signaling pathway mutation on I receptor ALK2, encoded by ACVR1. potential impact non-mutated for ACVR1 is less...
Pediatric diffuse midline gliomas (pDMG) are an aggressive type of childhood cancer with a fatal outcome. Their major epigenetic determinism has become clear, notably the identification K27M mutations in histone H3. However, synergistic oncogenic mechanisms that induce and maintain tumor cell phenotype have yet to be deciphered. In 20 30% cases, these tumors altered BMP signaling pathway mutation on I receptor ALK2, encoded by ACVR1. potential impact non-mutated for ACVR1 is less clear. By...
Abstract Transforming growth factor (TGFβ) is a secreted factor, which accumulates in tissues during many physio- and pathological processes such as embryonic development, wound healing, fibrosis cancer. In order to analyze the effects of increased microenvironmental TGFβ concentration vivo , we developed conditional transgenic mouse model (Flpo/Frt system) expressing bioactive fibroblasts, cell population present microenvironment almost all tissues. To achieve this, created...
Pediatric diffuse midline gliomas (pDMG) are an aggressive type of childhood cancer with a fatal outcome. Their major epigenetic determinism has become clear, notably the identification K27M mutations in histone H3. However, synergistic oncogenic mechanisms that induce and maintain tumor cell phenotype have yet to be deciphered.In 20 30% cases, these tumors altered BMP signaling pathway mutation on I receptor ALK2, encoded by ACVR1. potential impact non-mutated for ACVR1 is less clear. By...