A5058931808- DNA Repair Mechanisms
- BRCA gene mutations in cancer
- Natural Language Processing Techniques
- CRISPR and Genetic Engineering
- Topic Modeling
- Microtubule and mitosis dynamics
- Cancer Research and Treatments
- Genetic Neurodegenerative Diseases
- RNA modifications and cancer
- Photoacoustic and Ultrasonic Imaging
- Single-cell and spatial transcriptomics
- Genomics and Chromatin Dynamics
- Carcinogens and Genotoxicity Assessment
- Epigenetics and DNA Methylation
- Music and Audio Processing
- Robot Manipulation and Learning
- Speech Recognition and Synthesis
- Extracellular vesicles in disease
- Advanced Biosensing Techniques and Applications
- Multimodal Machine Learning Applications
- Photonic and Optical Devices
- Sparse and Compressive Sensing Techniques
- Robotic Path Planning Algorithms
- Biosensors and Analytical Detection
- Metalloenzymes and iron-sulfur proteins
Korea Institute of Toxicology
2024
The Ohio State University Wexner Medical Center
2021-2024
The Ohio State University
2017-2023
Seoul National University
2023
Miltenyi Biotec (Germany)
2023
Korea Advanced Institute of Science and Technology
2023
Naver (South Korea)
2021
Gwangju Institute of Science and Technology
2019-2020
Pusan National University
2016-2018
Pukyong National University
2018
Large-scale language models such as GPT-3 are excellent few-shot learners, allowing them to be controlled via natural text prompts. Recent studies report that prompt-based direct classification eliminates the need for fine-tuning but lacks data and inference scalability. This paper proposes a novel augmentation technique leverages large-scale generate realistic samples from mixture of real samples. We also propose utilizing soft-labels predicted by models, effectively distilling knowledge...
Boseop Kim, HyoungSeok Sang-Woo Lee, Gichang Donghyun Kwak, Jeon Dong Hyeon, Sunghyun Park, Sungju Seonhoon Dongpil Seo, Heungsub Minyoung Jeong, Sungjae Minsub Suk Hyun Ko, Seokhun Taeyong Jinuk Soyoung Kang, Na-Hyeon Ryu, Kang Min Yoo, Minsuk Chang, Soobin Suh, Sookyo In, Jinseong Kyungduk Hiun Jisu Yong Goo Yeo, Donghoon Ham, Dongju Young Jaewook Inho Jung-Woo Ha, Woomyoung Nako Sung. Proceedings of the 2021 Conference on Empirical Methods in Natural Language Processing. 2021.
Compressive sensing (CS) spectroscopy is well known for developing a compact spectrometer which consists of two parts: compressively measuring an input spectrum and recovering the using reconstruction techniques. Our goal here to propose novel residual convolutional neural network (ResCNN) reconstructing from compressed measurements. The proposed ResCNN comprises learnable layers connection between output these layers. trained both synthetic measured spectral datasets. results demonstrate...
Abstract Non-small cell lung carcinoma (NSCLC) is leading cause of cancer-related deaths in the world. The Tumor Suppressor Candidate 3 (TUSC3) at chromosome 8p22 known to be frequently deleted cancer often found advanced stage solid tumors. However, role TUSC3 still remains controversial and context-dependent several cancers. Here we propose that miR-224/-520c-dependent deficiency enhances metastatic potential NSCLC through alteration three unfolded protein response pathways HRD1-dependent...
Abstract Fhit protein is lost in cancers of most, perhaps all, cancer types; when restored, it can induce apoptosis and suppress tumorigenicity, as shown vitro mouse tumor models vivo. Following cross-linking proteomics analyses, we characterized a complex involved triggering Fhit-mediated apoptosis. The includes the heat-shock chaperonin pair, HSP60/10, which likely importing into mitochondria, where interacts with ferredoxin reductase, responsible for transferring electrons from NADPH to...
The replisome is a protein complex on the DNA replication fork and functions in dynamic environment at intersection of parental nascent chromatin. Parental nucleosomes are disrupted front fork. daughter duplexes packaged with an equal amount newly synthesized histones wake through activity replication-coupled chromatin assembly pathway. Histone acetyltransferase 1 (HAT1) responsible for cytosolic diacetylation histone H4 lysines 5 12, which accompanies assembly. Here, using proximity...
Abstract The interferon stimulated gene 15 (ISG15), a ubiquitin like protein and its conjugates have been implicated in various human malignancies. However, role ovarian cancer progression metastasis is largely unknown. In high grade serous (HGSOC), ascites the major contributor to peritoneal metastasis. this study, we identified significantly elevated ISG15 expression HGSOC patient ascites, derived primary cells (POCCs), POCC small extracellular vesicles (sEVs) as well metastatic tissue....
Abstract The importance of the tumor–associated stroma in cancer progression is clear. However, it remains uncertain whether early events are capable initiating breast tumorigenesis. Here, we show that mammary glands non-tumor bearing mice, stromal-specific phosphatase and tensin homolog ( Pten ) deletion invokes radiation-induced genomic instability neighboring epithelium. In these animals, a single dose whole-body radiation causes focal lobuloalveolar hyperplasia through paracrine...
The tumor suppressor BRCA1 regulates the DNA damage response (DDR) and other processes that remain incompletely defined. Among these, heterodimerizes with BARD1 to ubiquitylate targets via its N-terminal E3 ligase activity. Here, it is demonstrated promotes oxidative metabolism by degrading Oct1 (POU2F1), a transcription factor proglycolytic tumorigenic effects. ubiquitin mutation skews cells toward glycolytic metabolic profile while elevating protein. CRISPR-mediated deletion reverts...
Abstract Spatial Biology has evolved from the molecular characterization of microdissected cells to high throughput spatial RNA and protein expression analysis at scale. The main limitation technologies so far is inability resolve information in same histological section. Here, we report for first time integration highly multiplexed detection on tissue We developed a new, automated, method (RNAsky™), which based targeted rolling circle amplification iterative staining. combine RNAsky with...
In this paper, a combination of kinematic controller and dynamic is proposed to solve the problem leader-follower formation control for multiple wheeled mobile robots(WMR). Lidar sensor which equipped on leader robot utilized search measure relative distance angle between each follower robot. With information, designed generate command velocity then generated taken as reference input based sliding mode control(SMC) strategy. Lyapunov stability theory verifies that with all error signals can...
In optical filter based compressive sensing (CS) spectrometers, an input spectrum is multiplexed and modulated by a small number of filters which have different patterns. Then, detectors read out the signals called measurements. By exploiting CS reconstruction algorithms that utilize measurements patterns filters, recovered. However, there exists drawback on algorithms. The should be sparse signal or sparsely represented pre-determined sparsifying basis. practice, however, could not...
Alterations of the PALB2 tumor suppressor gene have been identified in familial breast, ovarian and pancreatic cancer cases. cooperates with BRCA1/2 proteins through physical interaction initiation homologous recombination, maintenance genome integrity following DNA double-strand breaks. To determine if role as a linker between BRCA1 BRCA2 is critical for BRCA1/2-mediated suppression, we generated Palb2 mouse models compared latencies, phenotypes drug responses previously Brca1/2 models. For...
In this paper, we designed the mathematical models for InSb and GaAs devices which are hall sensors with different characteristics confirmed efficacy of two through simulation in MATLAB. Assuming limitations on computational capability microprocessor will be used to compensate nonlinearity due temperature real system, linear regression compensation is divided into several sections performed first order polynomial. The error rate between curve fitted by data received from sensor was...
Wwox-deficient human cells show elevated homologous recombination, leading to resistance killing by double-strand break-inducing agents. Human Wwox binds the Brca1 981-PPLF-984 Wwox-binding motif, likely blocking pChk2 phosphorylation site at Brca1-S988. This is conserved across mammalian species; PPLF motif in primates but not rodents. We now that murine does bind near mouse phospho-S971 site, leaving it open for Chk2 and activation. Instead, through its BRCT domain, where pAbraxas, pBrip1,...
Korean red ginseng (KRG) is a product from roots, which enriched with ginsenosides and has been utilized for long time as an adaptogen to alleviate various physiological or disease conditions. While KRG generally considered safe, conducting thorough toxicological assessment of the spray-dried powder G1899 during juvenile period essential establish its safety profile. This study aimed assess using Sprague-Dawley rats. Two studies were conducted separately: toxicity uterotrophic bioassay. To...
Abstract The HubMap consortium has developed a new standard to report on normal histological samples using multicolor immunofluorescence imaging. An Organ Mapping Antibody Panel (OMAP) currently describes in table the antibodies used, cycle number assigned given reagent, and provides rationale for particular antibody better understand features of tissue. This is accompanied by validation templates that show example images from tissue described OMAP table. In addition, links existing...