A5051791762- Blood Coagulation and Thrombosis Mechanisms
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Cytokine Signaling Pathways and Interactions
- Protease and Inhibitor Mechanisms
- Diabetes and associated disorders
- Atherosclerosis and Cardiovascular Diseases
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Venous Thromboembolism Diagnosis and Management
- Hemophilia Treatment and Research
- Renin-Angiotensin System Studies
- Genetic Associations and Epidemiology
- Pancreatic function and diabetes
- Blood properties and coagulation
- Nigella sativa pharmacological applications
- Folate and B Vitamins Research
- Birth, Development, and Health
- Endometriosis Research and Treatment
- Ovarian function and disorders
- Diabetes Management and Research
- Cardiovascular Issues in Pregnancy
- Platelet Disorders and Treatments
Hôpital Cochin
2025
Assistance Publique – Hôpitaux de Paris
2025
University of Monastir
2014-2023
Hospital Fatuma Bourguiba Monastir
2014
Hôpital Farhat Hached
2001-2014
Laboratory of Molecular Genetics
2011
Salmaniya Medical Complex
2007-2010
Arabian Gulf University
2007-2010
Laboratoire de Biochimie
2010
University of Sousse
2009
Because they have been described as strong risk factors for idiopathic recurrent pregnancy losses (RPLs), we assessed the association between methylenetetrahydrofolate reductase (MTHFR) single-nucleotide polymorphisms (SNPs) C677T and A1298C hyperhomocysteinemia in Tunisian women with RPL. Study subjects comprised 200 patients more than three consecutive RPLs, age-matched parous control women. SNPs were analyzed by PCR-RFLP analysis, fasting serum homocysteine was measured ELISA. The...
Abstract Background Candidate gene and genome-wide association studies have both reproducibly identified several common Single Nucleotide Polymorphisms (SNPs) that confer type 2 diabetes (T2D) risk in European populations. Our aim was to evaluate the contribution T2D of five these established T2D-associated loci Arabic population from Tunisia. Methods A case-control design comprising 884 diabetic patients 513 control subjects living East-Center Tunisia used analyze following SNPs: E23K...
We have performed this study to investigate the modulatory effect of thymoquinone (TQ), Nigella sativa active compound, on erythrocyte lipid peroxidation and antioxidant status during 1,2-dimethylhydrazine- (DMH-) induced colon carcinogenesis after initiation in male Wistar rats. Rats exposed DMH showed an increase malondialdehyde conjugated diene levels, augmentation enzyme activities like catalase, glutathione peroxidase, superoxide dismutase was also noted. The TQ pretreatment restored...
Is recurrent pregnancy loss (RPL) associated with polymorphisms in the promoter and intron regions of interleukin-10 (IL-10) gene?IL-10 rs1518111 was found to be RPL but commonly studied variants rs1800872, rs1800871 1800896 were not.Reduced expression IL-10 is implicated RPL, due defective maternal immune tolerance (causing early miscarriages) or placental vascular insufficiency late losses). production part inherited, gene reduced have been analyzed for their association often inconclusive...
In addition to HLA and insulin genes, the costimulatory molecule CTLA-4 gene is a confirmed type 1 diabetes (T1D) susceptibility gene. Previous studies investigated association of genetic variants with risk T1D, but inconclusive findings. Here, we tested contributions common T1D in Tunisian patients control subjects. The study subjects comprised 228 (47.8% females) 193 unrelated healthy controls (45.6% females). Genotyping for CT60A/G (rs3087243), +49A/G (rs231775), -318C/T (rs5742909) was...
Polycystic ovary syndrome (PCOS) is characterized by the growth of a number small cysts on ovaries which leads to sex hormonal imbalance. Women who are affected this suffer from irregular menstrual cycles, decline in their fertility, excessive hair growth, obesity, acne and most importantly cardiac function problems. The vascular endothelial factor (VEGF) plays pivotal role tissue vascularization general pathogenesis many diseases. PCOS was found be associated with high expression levels...
Summary Background The Interleukin (IL)‐10 polymorphic variants –1082G/A, –819C/T and –592C/A were linked with obesity, metabolic syndrome, type 2 diabetes (T2DM). We investigated the hypothesis that IL‐10 promoter polymorphisms may be associated progression of diabetic nephropathy (DN). Design Case‐controlled study. Patients Study subjects comprised 515 DN patients, 402 normoalbuminuric (DWN) T2DM patients. Measurements genotyping was done by PCR‐based assays, contributions to analysed...
Myocardial infarction (MI) is induced by acquired and inherited risk factors, including the plasminogen activator inhibitor-1 (PAI-1) -844G/A -675G/A (4G/5G) gene variants.The aim of this study was to investigate association between PAI-1-844G/A 4G/5G polymorphisms changes in PAI-1 tissue (tPA) levels MI a Tunisian population.This case-control involving 305 patients with 328 unrelated healthy controls. genotyping done polymerase chain reaction-restriction fragment length polymorphism (RFLP)...
Problem Plasminogen activator inhibitor type 1 (PAI-1) regulates fibrinolysis, and the common promoter region variants −675G/A (4G/5G) −844G/A are associated with increased thrombotic risk. Despite evidence linking altered fibrinolysis adverse pregnancy events, including idiopathic recurrent loss (RPL), contribution of PAI-1 to RPL risk remains controversial. We investigated association between 4G/5G (−675G/A) RPL. Method study This was a case–control involving 304 women confirmed 371 age-...
Increasing evidence supports a role for altered T helper 1 (Th1)-Th2 cytokine balance in idiopathic recurrent spontaneous abortion (RSA). The aim of this study was to investigate the association interleukin 10 (IL-10) promoter polymorphisms -592C/A, -819C/T and -1082A/G with RSA. Women (n = 350) at least three consecutive abortions (RSA cases) 200 control women two successful pregnancies were included. frequency -819T allele [P 0.05, odds ratio (OR) 1.51], but not other single-nucleotide...
Polymorphisms of the endothelial nitric oxide synthase (eNOS) gene have been associated with reduced vascular NO production or increased level homocysteine, and evaluated as risk factors for recurrent pregnancy loss (RPL). Therefore, in this case-control study, we aimed to determine effects some eNOS functional polymorphisms: 27-bp intron 4 repeat, 894G/T exon 7, promoter substitution -786T/C, women RPL.We genotyped 350 patients RPL 200 healthy by polymerase chain reaction (PCR) restriction...