A5045144382- Reproductive System and Pregnancy
- Blood Coagulation and Thrombosis Mechanisms
- Pregnancy and preeclampsia studies
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Ovarian function and disorders
- Diabetes and associated disorders
- Hemoglobinopathies and Related Disorders
- Cytokine Signaling Pathways and Interactions
- Venous Thromboembolism Diagnosis and Management
- Cell Adhesion Molecules Research
- Renal Transplantation Outcomes and Treatments
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Reproductive Biology and Fertility
- Blood groups and transfusion
- Cervical Cancer and HPV Research
- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Iron Metabolism and Disorders
- Hormonal Regulation and Hypertension
Tunis El Manar University
2017-2025
Tunis University
2017-2025
Brock University
2023-2025
Nazarbayev University
2019-2024
Abu Dhabi University
2020-2024
Lebanese American University
2018
Harvard University
1991-2018
Arabian Gulf University
2008-2017
GTx (United States)
2011
Gulf University
2011
Glucocorticoids (GCs) exert their anti-inflammatory and immunosuppressive effects by inhibiting the expression of cytokines adhesion molecules. The molecular basis GC action lies in capacity to diffuse through cell membrane bind cytosolic receptor (GR), which subsequently undergoes nuclear translocation modulates transcriptional activation association with promoter elements, response elements (GRE). GR also antagonized activity transcription factors, including NF-kappa B, NF-AT, AP-1, direct...
Because they have been described as strong risk factors for idiopathic recurrent pregnancy losses (RPLs), we assessed the association between methylenetetrahydrofolate reductase (MTHFR) single-nucleotide polymorphisms (SNPs) C677T and A1298C hyperhomocysteinemia in Tunisian women with RPL. Study subjects comprised 200 patients more than three consecutive RPLs, age-matched parous control women. SNPs were analyzed by PCR-RFLP analysis, fasting serum homocysteine was measured ELISA. The...
This is the first genetic anthropology study on Arabs in MENA (Middle East and North Africa) region. The present meta-analysis included 100 populations from 36 Arab non-Arab communities, comprising 16,006 individuals, evaluates profile of using HLA class I (A, B) II (DRB1, DQB1) genes. A total 56 10,283 individuals were selected several databases, compared with 44 Mediterranean, Asian, sub-Saharan populations. most frequent alleles are A*01, A*02, B*35, B*51, DRB1*03:01, DRB1*07:01,...
Abstract Factor V G1691A (FV‐Leiden) and prothrombin G20210A mutations are major inherited risk factors for venous thrombosis. Recently, it was suggested that both mutations, through stimulation of placental thrombosis events, were strongly associated with recurrent idiopathic miscarriages, although other studies disputed such a link. The aim this study to determine the prevalence factor (R506Q, FV‐Leiden) in women abortions recommend management high‐risk mutation carriers. One hundred ten...
Department of Medicine, Case Western Reserve University School Hospitals Cleveland, Ohio 44106; Biochemistry, American Beirut, Lebanon; and Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02215
Department of Medicine, Case Western Reserve University School Hospitals Cleveland, Ohio 44106; Biochemistry, American Beirut, Lebanon; and Beth Israel Hospital, Harvard Medical School, Boston, Massachusetts 02215
Abstract Background Candidate gene and genome-wide association studies have both reproducibly identified several common Single Nucleotide Polymorphisms (SNPs) that confer type 2 diabetes (T2D) risk in European populations. Our aim was to evaluate the contribution T2D of five these established T2D-associated loci Arabic population from Tunisia. Methods A case-control design comprising 884 diabetic patients 513 control subjects living East-Center Tunisia used analyze following SNPs: E23K...
Is recurrent spontaneous miscarriage (RSM) associated with changes in vascular endothelial growth factor (VEGF) serum levels, and polymorphisms the VEGFA gene? Reduced VEGF −460T/C (rs833061), 398G/A (rs833068), −583T/C (rs3025020) variants, were RSM. expression of has been linked miscarriage, likely due to defective fetal placental angiogenesis. Since production is part inherited, altered secretion have investigated for their association RSM, often variable conclusions. A retrospective...
Vascular endothelial growth factor (VEGF) is a pro-angiogenic factor. Variability in VEGF expression, induced by specific VEGFA variants, are involved angiogenesis-related disorders. This study examined the genotype distribution and functional role (VEGF expression) of rs699947, rs833061, rs1570360, rs2010963, rs833068, rs833070, rs3025020, rs3025039 variants their haplotypes 519 healthy Bahraini individuals both genders.The eight polymorphisms screened was Hardy-Weinberg equilibrium. The...
Is recurrent pregnancy loss (RPL) associated with polymorphisms in the promoter and intron regions of interleukin-10 (IL-10) gene?IL-10 rs1518111 was found to be RPL but commonly studied variants rs1800872, rs1800871 1800896 were not.Reduced expression IL-10 is implicated RPL, due defective maternal immune tolerance (causing early miscarriages) or placental vascular insufficiency late losses). production part inherited, gene reduced have been analyzed for their association often inconclusive...