A5070323182- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Neurological diseases and metabolism
- Neurological disorders and treatments
- Neurogenetic and Muscular Disorders Research
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Cholinesterase and Neurodegenerative Diseases
- Hepatitis B Virus Studies
- Immune Response and Inflammation
- Multiple Sclerosis Research Studies
- Genomics and Rare Diseases
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- Cytokine Signaling Pathways and Interactions
- Cervical Cancer and HPV Research
- Lysosomal Storage Disorders Research
- Systemic Lupus Erythematosus Research
- Nuclear Receptors and Signaling
- Research on Leishmaniasis Studies
- Genetic Neurodegenerative Diseases
- Dementia and Cognitive Impairment Research
- Effects of Vibration on Health
- Nuclear Structure and Function
Hôpital Razi de La Manouba
2019-2025
Manouba University
2019-2025
Tunis El Manar University
2014-2024
Tunis University
2018-2023
Faculté de médecine de Tunis
2022-2023
Razi Hospital
2022
Razi University
2022
University of Missouri Health System
2020
University of Missouri
2020
Institut Pasteur de Tunis
2015
Background: Chronic infection with hepatitis B (HBV) and C virus (HCV) is linked a pro-inflammatory state, predisposing to cirrhosis liver cancer, particularly hepatocellular carcinoma (HCC). A role for Toll-like receptor (TLR) signalling in hepatocarcinogenesis was recently documented. We hypothesised link TLR3 TLR4 polymorphisms HCC, as surrogates the significance of TLR promotion initiation HCC.Materials methods: recruited 174 HCV-infected patients, 100 HBV-infected patients 360 healthy...
Objective: To describe the phenotypic heterogeneity of amyotrophic lateral sclerosis (ALS) in Tunisian patients, and to define sociodemographic features, treatments, survival rate with ALS. Methodology: The study included 210 patients ALS diagnosed between 2003 2019 Neurology department, Razi Hospital Tunisia. were phenotyped followed until their death. Results: median age onset was 54.93 ± 14.08 years (men = 56.21 12.58, women 52.36 16.49). sex-ratio 2.0 obvious male predominance. Juvenile...
Objective Progressive supranuclear palsy (PSP) is a rare neurodegenerative disorder encompassing several phenotypes with various motor and cognitive deficits. We aimed to study characteristics across PSP assess the influence of apolipoprotein E (<i>APOE</i>) gene variants on phenotypic expression.Methods In this 20-year cross-sectional study, we retrospectively reviewed charts all patients classified as recategorized them according phenotype using Movement Disorder Society...
Objective <i>LRRK2</i>-G2019S is the most frequent mutation in North African Parkinson’s disease (PD) patients. Data on its impact progression and treatment response remain elusive. Therefore, we investigated clinical features, treatments, complications of PD Tunisian patients according to their profile.Methods This longitudinal retrospective study was performed Department Neurology, Razi University Hospital. We included clinically diagnosed Movement Disorders Society criteria...
Several studies implicated altered inflammatory response in the susceptibility to ovarian cancer, and polymorphisms cytokines were shown play an important role development of malignancies, including cancer (OC). Here we investigated relationship between IL-1β (-511C>T), IL-1RN VNTR, TNF-α (-308G>A), TNF RII (-322 VNTR) OC risk Tunisian women.Study subjects comprised 62 patients 126 healthy women. Genotyping was done from genomic DNA obtained blood simple by PCR. Positive association (-VNTR)...
Colorectal cancer (CRC) is the third most diagnosed malignancy worldwide. The global burden expected to increase along with ongoing westernized behaviors and lifestyle. etiology of CRC remains elusive likely combines environmental genetic factors. Kv2.1 potassium channel encoded by KCNB1 plays a collection roles in may be key factor susceptibility. Our study provides baseline association between Tunisian interactions variants lifestyle factors.A case-control involving 300 patients, controls...