A5091600959- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Renal Transplantation Outcomes and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Drug-Induced Adverse Reactions
- Pneumocystis jirovecii pneumonia detection and treatment
- Nail Diseases and Treatments
- SARS-CoV-2 and COVID-19 Research
- Chronic Lymphocytic Leukemia Research
- Liver Disease and Transplantation
- Antifungal resistance and susceptibility
- Chronic Myeloid Leukemia Treatments
- Analytical Methods in Pharmaceuticals
- Drug-Induced Hepatotoxicity and Protection
- Organ Transplantation Techniques and Outcomes
- Acute Lymphoblastic Leukemia research
- Pneumonia and Respiratory Infections
- Cancer Treatment and Pharmacology
- Autoimmune Bullous Skin Diseases
- Liver Disease Diagnosis and Treatment
- Chemotherapy-induced organ toxicity mitigation
- Nausea and vomiting management
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 detection and testing
Tunis El Manar University
2014-2024
Tunis University
2011-2024
Faculté de médecine de Tunis
2011-2024
Institut National de Nutrition et de Technologie Alimentaire
2023
Hôpital Charles-Nicolle
2007-2018
University of Monastir
2018
National Sanitation Utility
2011-2018
Centre Hospitalier Universitaire de Grenoble
2017
Laboratoire de Biophotonique et Pharmacologie
2014
Hopital Universitaire Hedi Chaker
2008
Objective <i>LRRK2</i>-G2019S is the most frequent mutation in North African Parkinson’s disease (PD) patients. Data on its impact progression and treatment response remain elusive. Therefore, we investigated clinical features, treatments, complications of PD Tunisian patients according to their profile.Methods This longitudinal retrospective study was performed Department Neurology, Razi University Hospital. We included clinically diagnosed Movement Disorders Society criteria...
This study aims to construct geographically, temporally, and epidemiologically representative datasets for SARS-CoV-2 in North Africa, focusing on VOCs, VOIs, VUMs. genomic sequences metadata from the EpiCoV database via GISAID platform were analyzed. Data analysis included cases, deaths, demographics, patient status, sequencing technologies, variant analysis. A comprehensive of 10,783 viral six African countries revealed notable insights. sampling methods lack standardization, with a...
Genetic variation is an important determinant affecting either drug response or susceptibility to adverse reactions. Several studies have highlighted the importance of ethnicity in influencing variability that should be considered during development. Our objective characterize genetic some pharmacogenes involved drugs used for treatment Metabolic Syndrome (MetS) Tunisia and compare our results worldwide populations. A set 135 Tunisians was genotyped using Affymetrix Chip 6.0 genotyping...
Measurements of Cyclosporine (CsA) systemic exposure permit its dose adjustment in allogenic stem cell transplantation recipients to prevent graft-versus-host disease. CsA LSSs were developed and validated from 60 ASCT patients via multiple linear regressions. All whole-blood samples analyzed by fluorescence polarization immunoassay (FPIA-Axym). The 10 models that have used concentrations at a single time point did not good fit with AUC(0-12) (R(2) < 0.90). C(2) C(4) the points correlated...
Since the beginning of Coronavirus disease-2019 pandemic, there has been a growing interest in exploring SARS-CoV-2 genetic variation to understand origin and spread improve diagnostic methods develop appropriate vaccines. The objective this study was identify SARS-CoV-2s lineages circulating Tunisia explore their amino acid signature order follow genome dynamics. Whole sequencing analyses fifty-eight samples collected during one-year between March 2020 2021 from National Influenza Center...
The aim of this study is to evaluate the features visceral leishmaniasis (VL) in adults with nephropathy, who were not infected human immunodeficiency virus. This a retrospective 14 hospitalized between 2000 and 2014, VL renal involvement. Clinical, biological, therapeutic data collected from patients' medical files. Eleven women three men, most whom North country, mean age 40.5 years studied. Lupus was present five cases, Sicca syndrome diabetes one case, failure on dialysis two there...
Objective : Laryngeal injuries are rare. They can be isolated or associated with fractures of the facial skeleton. Early diagnosisand proper initial management may sometimes difficult delayed.The indication for surgery depends on extent injury.Materials and methods We report a retrospective review including thirty patients laryngeal trauma treated over 25-year periodResults The mean age was 30 years. Commonest cause injury cut throat followed by road traffic accidents. Fibreoptic endoscopy...
Tacrolimus is a calcineurin inhibitor primarily metabolized by CYP3A4 and secondarily CYP3A5. Several drugs can modify tacrolimus blood levels as calcium channel blockers (CCBs). Interaction with nicardipine was reported in some cases. A man history of malignant arterial hypertension treated nicardipine, underwent kidney transplantation. After transplantation, he tacrolimus, mycophenolate mofetil corticoids. Therapeutic drug monitoring done regularly showing mean trough concentration (C0)...