A5102950972- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- Protein Structure and Dynamics
- thermodynamics and calorimetric analyses
- Spectroscopy Techniques in Biomedical and Chemical Research
- Catalysis and Hydrodesulfurization Studies
- Spaceflight effects on biology
- Catalysis for Biomass Conversion
- Radiation Therapy and Dosimetry
- Catalytic Processes in Materials Science
- Genetics, Aging, and Longevity in Model Organisms
- Catalysts for Methane Reforming
- Chemical Synthesis and Characterization
- Bee Products Chemical Analysis
- Metabolomics and Mass Spectrometry Studies
- Biochemical effects in animals
- Lignin and Wood Chemistry
- Nanoparticle-Based Drug Delivery
- Innovative Microfluidic and Catalytic Techniques Innovation
- Field-Flow Fractionation Techniques
- Healthcare and Venom Research
- Environmental and Industrial Safety
- Industrial Gas Emission Control
- Extracellular vesicles in disease
Federal Almazov North-West Medical Research Centre
2022-2025
Institute of Cytology
2022-2025
Saint Petersburg State Academy of Veterinary Medicine
2023-2025
St Petersburg University
2023-2025
Åbo Akademi University
2018-2019
St. Petersburg State Technological Institute
2019
Institute of Laser Physics
2016
ITMO University
2016
We studied an influence of continuous terahertz (THz) radiation (0.12 - 0.18 THz, average power density 3.2 mW/cm2) on a rat glial cell line. A dose-dependent cytotoxic effect THz is demonstrated. After 1 minute exposure relative number apoptotic cells increased in 1.5 times, after 3 minutes it doubled. This result confirms the concept biological hazard intense radiation. Diagnostic applications can be restricted by and time.
The colloidal long-storage stability of nanosized drugs is a crucial factor for pharmacology, as they require much time robust estimation. application bioavailable magnetic nanosuspensions in theranostics limited by incomplete information about their the internal media human organisms. A method accelerated temperature stress “aging” suspensions proposed rapid assessment and prediction over iron oxide stabilized albumin HSA. Colloidal assessed using dynamic light scattering (DLS),...
Multiforme glioblastoma-homing peptides, particularly targeting plasma membrane-bound heat shock protein mHsp70, demonstrate great application potential for tumor theranostics. In the current study, to further increase bioavailability as well penetration capacity through blood-brain barrier (BBB) of mHsp70-targeted peptide TKDNNLLGRFELSG, which is known bind oligomerization sequence mHsp70 chaperone, latter was conjugated with tripeptide RGD (forming chimeric termed RAS70). model BBB system...
<p>Automatic cell tracking before the AI model is applied. TMS line, a well without addition of inhibitors on Poly-L-lysine matrix.</p>
<p>Motility of Hsp70-positive cells in a GBM tumor sample detected using laser scanning confocal microscopy during observation for 1 h.</p>
<p>Motility of Hsp70-positive cells emerging from a piece tumor during cultivation for three days.</p>
<p>Migration of cells out spheroids. TMS cell line, a well without the addition inhibitors on Poly-L-lysine matrix.</p>
<p>Effect of Hsp70 inhibitors PES and JG-98 on cell viability analyzed using the MTT assay.</p>
<p>Motility of Hsp70-positive cells in a GBM tumor sample detected using laser scanning confocal microscopy during observation for 1 h, zoomed field view from the center Video S1 frame.</p>
<p>Preparing a tumor sample for confocal microscopy.</p>
<p>Gating of mHsp70High cells (field R2) and mHsp70Low R3) by FACS.</p>
<p>CD133 expression in C6, T98G and U251 cell lines measured by flow cytometry.</p>
<p>Confocal microscopy images of primary glioblastoma cells from patients stained for mHsp70 and Nestin.</p>
<p>Comparison of mean speed and track straightness on various matrices (PL, MG, FN) patient-derived (non-sorted into high- low-speed subpopulations) brain tumor cells treated with 1 µM PES or 50 nM JG-98.</p>
<p>Motility of Hsp70-positive cells in a tumor sample.</p>
<p>The sequence of constructing a phenotyping map for histological sections human GBM.</p>
<p>Evaluation of biomarkers co-localization.</p>
<p>Cells of the TMS cell line in well with addition a PES inhibitor on matrigel matrix.</p>