A5024597852- Marine Biology and Ecology Research
- Bone Tissue Engineering Materials
- Parasite Biology and Host Interactions
- Mollusks and Parasites Studies
- Genetic diversity and population structure
- Electrospun Nanofibers in Biomedical Applications
- Aquatic Invertebrate Ecology and Behavior
- Tissue Engineering and Regenerative Medicine
- Marine Biology and Environmental Chemistry
- Collagen: Extraction and Characterization
- Genetic Neurodegenerative Diseases
- Isotope Analysis in Ecology
- Mesenchymal stem cell research
- Marine Bivalve and Aquaculture Studies
- Environmental DNA in Biodiversity Studies
- 3D Printing in Biomedical Research
- Corneal Surgery and Treatments
- Marine and coastal plant biology
- biodegradable polymer synthesis and properties
- Pluripotent Stem Cells Research
- Insect and Arachnid Ecology and Behavior
- Neurological Disorders and Treatments
- CRISPR and Genetic Engineering
- Wound Healing and Treatments
- Neurological disorders and treatments
Federal Almazov North-West Medical Research Centre
2024-2025
Institute of Cytology
2004-2024
Russian Academy of Sciences
2013-2024
Research Institute of Vaccines and Sera. Mechnikov of the Russian Academy of Medical Sciences
2023
First Pavlov State Medical University of St. Petersburg
2019-2023
St Petersburg University
2013-2022
Federal Research Center of Fundamental and Translational Medicine
2022
East Carolina University
2022
Lomonosov Moscow State University
2021
Russian Railways
2021
Abstract Extrapulmonary tuberculosis with a renal involvement can be manifestation of disseminated infection that requires therapeutic intervention, particularly decrease in efficacy conventional regimens. In the present study, we investigated potency mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) complex anti-tuberculosis treatment (ATT). A rabbit model (rTB) was constructed by injecting standard strain Mycobacterium H37Rv into cortical layer kidney parenchyma. Isolated...
Information on spatial and temporal patterns of genetic diversity is a prerequisite to understanding the demography populations, fundamental successful management conservation species. In sea, it has been observed that oceanographic other physical forces can constitute barriers gene flow may result in similar population structures different Such similarities among species would greatly simplify biodiversity. Here, we tested for shared complex marine area, Baltic Sea. We assessed...
Multiforme glioblastoma-homing peptides, particularly targeting plasma membrane-bound heat shock protein mHsp70, demonstrate great application potential for tumor theranostics. In the current study, to further increase bioavailability as well penetration capacity through blood-brain barrier (BBB) of mHsp70-targeted peptide TKDNNLLGRFELSG, which is known bind oligomerization sequence mHsp70 chaperone, latter was conjugated with tripeptide RGD (forming chimeric termed RAS70). model BBB system...
Abstract Heat shock proteins (HSP), particularly 70 kDa heat protein (Hsp70), apart from their cytoplasmic localization in cancer cells, can be exposed on the surface of plasma membrane. We report that membrane-bound mHsp70 malignant brain tumors is required for high migratory and invasive activity cells. Live-cell inverted confocal microscopy adult pediatric tumor samples (n=32) showed overexpression membrane, especially perifocal zone. Mass-spectrometry analysis lipid rafts isolated cells...
The modeling of neuropathology on induced neurons obtained by cell reprogramming technologies can fill a gap between clinical trials and studies model organisms for the development treatment strategies neurodegenerative diseases. Patient-specific models based patients' cells play an important role in such studies. There are two ways to obtain neuronal cells. One is pluripotent stem other direct reprogramming, which allows us mature from adult somatic cells, as dermal fibroblasts. Moreover,...
Abstract A new in vitro model of Huntington’s disease (HD) was developed via a direct reprogramming dermal fibroblasts from HD patients into striatal neurons. induced pluripotent stem (iPS) cells is obviated the case reprogramming, which thus yields neurons that preserve epigenetic information inherent particular donor and, consequently, age-associated phenotype. main histopathological feature reproduced model; i.e., aggregates mutant huntingtin accumulated derived patient’s fibroblasts....
MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout JournalEditorsTheme Sections 552:177-193 (2016) - DOI: https://doi.org/10.3354/meps11770 Measuring physiological similarity of closely related littorinid species: a proteomic insight Arina L. Maltseva1,*, Marina A. Varfolomeeva1, Arseniy Lobov1, Natalia Mikhailova1,2, Paul E. Renaud3, Alexey V. Grishankov1, Kseniia Y. Volovik1, Andrei I....
Background The introduction of DNA-based molecular markers made a revolution in biological systematics. However, cases very recent divergence events, the neutral may be too slow, and analysis adaptive part genome is more informative to reconstruct evolutionary history young species. advantage proteomics its ability reflect biochemical machinery life. It help both identify rapidly evolving genes interpret their functions. Methods Here we applied comparative gel-based proteomic several species...
Divergence of ecological niches in phylogenetically closely related species indicates the importance ecology speciation, especially for sympatric are considered. Such diversification provides an advantage alleviating interspecies competition and promotes more efficient exploitation environmental resources, thus being a basis speciation. We analyzed group from subgenus Neritrema (genus Littorina, Caenogastropoda) gravel-bouldery shores. In two distant sites at Barents Norwegian Sea, we...
Abstract Microbes can play a prominent role in the evolution of their hosts, facilitating adaptation to various environments and promoting ecological divergence. The Wave Crab ecotypes intertidal snail Littorina saxatilis is an evolutionary model rapid repeated environmental gradients. While patterns genomic divergence along shore gradients have been extensively studied, microbiomes so far overlooked. aim present study start filling this gap by comparing gut microbiome composition using...
The review presents the history of creation "Collection Cell Cultures Vertebrate" (CCCV), which has been in operation for over 40 years. working principles, comprising seven points and covering both practical scientific activities CCCV, are discussed. Part is aimed at describing amount hands-on work associated with service delivery to CCCV’s users representing various institutions Russian Federation. quantitative indicators presented evidence active activity CCCV. Another part dedicated...
Abstract Reproductive isolation is the key attribute of biological species and establishment reproductive barriers an essential event for speciation. Among mechanisms isolation, gamete incompatibility due to variability interaction proteins may drive fast divergence even in sympatry. However, number available models study this phenomenon limited. In case internally fertilized invertebrates, sperm competition are restricted a single taxon: insects. Here, we propose group closely related...
Collagen in the body is exposed to a range of influences, including free radicals, which can lead significant change its structure. Modeling such an effect on collagen fibrils will allow one get native structure vitro, important for modern tissue engineering. The aim this work study radicals solution hydrogen peroxide with concentration 0.006-0.15% and response cells treatment. SEM measurements show decrease diameter increase peroxide. Such treatment also leads wetting angle surface. Fourier...
Any multicellular organism during its life is involved in relatively stable interactions with microorganisms. The and microbiome make up a holobiont, possessing unique set of characteristics evolving as whole system. This study aimed to evaluate the degree conservativeness microbiomes associated intertidal gastropods. We studied composition geographic phylogenetic variability gut body surface five closely related sympatric Littorina ( Neritrema ) spp. more distant species, L . littorea ,...
The first scientific forum «Genetic Resources of Russia» took place in Saint Petersburg on 21-24 June 2022. Forum brought together more than 500 specialists from 100 research institutions and universities the Russian Federation. A round table «Regulations standards work with bio-resource collections» was organized within framework connection relevance to create legislation base for biological collections regulation activities bioresource centres This publication presents outcomes its...
Metapopulation structure and genetic differentiation among subpopulations will be tightly related to patterns processes of local adaptation microevolution. Understanding the mechanisms behind substructuring aid in interpretation species' ecological performances strategies. The marine gastropod Littorina fabalis occurs two size morphs – a small large found microhabitats different wave exposure, but overlapping distribution where exposure is intermediate. Earlier studies have substantial...
Salinity is a crucial abiotic environmental factor for marine animals, affecting their physiology and geographic ranges.Deviation of salinity from the organismal optimum range results in an osmotic stress osmoconformers, which keep fluids isotonic to environment.The ability overcome such critical animals inhabiting areas with considerable variation, as intertidal areas.In this study, we compared reaction mild water freshening (from 24 14 ‰) two related species snails, Littorina saxatilis L....