A5069486013- Bone health and osteoporosis research
- Occupational Health and Performance
- Vitamin D Research Studies
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Body Composition Measurement Techniques
- Nutritional Studies and Diet
- Genetics and Physical Performance
- Iron Metabolism and Disorders
- Bone fractures and treatments
- Trace Elements in Health
- Folate and B Vitamins Research
- Bone health and treatments
- Plant Micronutrient Interactions and Effects
- Sports Performance and Training
- Magnesium in Health and Disease
- Nutrition, Genetics, and Disease
- Digestive system and related health
- Parathyroid Disorders and Treatments
- Vitamin C and Antioxidants Research
- Immune cells in cancer
- Barrier Structure and Function Studies
- Food Security and Health in Diverse Populations
Combat Capabilities Development Command Soldier Center
2013-2024
U.S. Army Research Institute of Environmental Medicine
2014-2024
United States Army
2012-2024
United States Army Combat Capabilities Development Command
2020-2024
United States Army Futures Command
2024
Massachusetts General Hospital
2016
Beth Israel Deaconess Medical Center
2016
Harvard University
2016
University of Connecticut
2009-2015
Yale University
2009-2015
Osteoporosis and sarcopenia are degenerative diseases frequently associated with aging. The loss of bone muscle results in significant morbidity, so preventing or attenuating osteoporosis is an important public health goal. Dietary protein crucial for development muscle, recent evidence suggests that increasing dietary above the current Recommended Allowance (RDA) may help maintain mass older individuals. Several epidemiological clinical studies point to a salutary effect intakes RDA (0.8...
Abstract Proton pump inhibitors (PPIs) are the most potent gastric acid suppressing drugs available, and their use is widespread. An emerging concern about chronic PPI therapy whether these impair intestinal calcium absorption, resulting in a negative balance thereby potentially causing bone loss. The objective of this study was to evaluate acute effect esomeprazole or placebo on absorption healthy adults. Twelve young adults participated placebo-controlled, double-blind, crossover study....
It has been assumed that the increase in urine calcium (Ca) accompanies an dietary protein was due to increased bone resorption. However, studies using stable Ca isotopes have found increases absorption without increasing resorption.The objective of study investigate impact a moderately high diet on mineral density (BMD).This randomized, double-blind, placebo-controlled trial supplementation daily for 18 months.The conducted at two institutional research centers.Two hundred eight older women...
The military dietary reference intakes (MDRIs), outlined in Army Regulation 40-25, OPNAVINST 10110.1/MCO10110.49, AFI 44–141, establish standards intended to meet the nutrient requirements of Warfighters. Therefore, purpose this study was comprehensively compare revised MDRIs, published 2017, with estimated U.S. personnel. During cross-sectional study, Block food frequency questionnaires were administered at end 9-week basic combat training course estimate intake during male (n = 307) and...
Soldiers must achieve high-level mission-preparedness to endure extended periods of physical and cognitive activity, with unpredictable recovery, in all environments. Nutrition provides the foundation for health performance. Militaries have not maximised strategic financial value that considering nutrition as a military capability could deliver. A whole system approach nutrition, based on prepare-perform-recover human cycle phases, is presented. Trainee requirements, through...
ABSTRACT Initial military training (IMT) is associated with increased stress fracture risk. In prior studies, supplemental calcium (Ca) and vitamin D provided daily throughout IMT reduced incidence, suppressed parathyroid hormone (PTH), improved measures of bone health compared placebo. Data were analyzed from a randomized, double-blind, placebo-controlled trial to determine whether single-nucleotide polymorphisms (SNPs) in Ca D–related genes circulating biomarkers metabolism young adults...
Musculoskeletal injuries (MSKIs) are common in military trainees and present a considerable threat to occupational fitness, deployability, overall readiness. Despite the negative effects of MSKIs on readiness, comprehensive evaluations key known possible risk factors for lacking. The U.S. Army Research Institute Environmental Medicine (ARIEM) is initiating large-scale research effort, ARIEM Reduction Injury (ARMI) Study, better understand interrelationships among wide range potential MSKI...
The purpose of this investigation was to assess the influence calorie restriction (CR) alone, higher-protein/lower-carbohydrate intake and combined CR on glucose homeostasis, hepatic de novo lipogenesis (DNL), intrahepatic triglycerides. Twelve-week old male Sprague Dawley rats consumed ad libitum (AL) or (40% restriction), adequate (10%), high (32%) protein (PRO) milk-based diets for 16 weeks. Metabolic profiles were assessed in serum, triglyceride concentrations molecular markers...
Increasing dietary protein intake in humans acutely increases urinary calcium. Isotopic absorption studies have indicated that, at least the short term, this is primarily due to increased intestinal Ca absorption. To explore mechanisms underlying protein’s effect on absorption, female Sprague Dawley rats were fed a control (20%), low (5%), or high (40%) diet for 7 d, and balance was measured during d 4–7. On 7, duodenal mucosa harvested brush border membrane vesicles (BBMVs) prepared...
Basic combat training (BCT) is a period of novel physical including load carriage resulting in higher risk stress fracture compared to any other time during military service. Prior trials reported 20% reduction incidence with Ca and vitamin D (Ca + D) supplementation (2000 mg Ca, 800 IU D), greater increases tibia vBMD BCT placebo. The primary objective this randomized, double-blind, placebo-controlled trial was determine the efficacy lower dose (1000 mg/d 1000 vit on PTH, bone biomarkers...
Abstract Aerobic exercise reduces circulating ionized Ca (iCa) and increases parathyroid hormone (PTH), but the cause consequences on handling are unknown. The objective of this study was to determine effects strenuous kinetics using dual stable isotopes. Twenty-one healthy women (26.4 ± 6.7 yr) completed a randomized, crossover entailing two 6-d iterations consisting either 60 min treadmill walking at 65% VO2max wearing vest weighing 30% body weight days 1, 3, 5 (exercise [EX]), or rest...
Abstract Ca/vitamin D supplementation maintains bone health and decreases stress fracture risk during initial military training (IMT); however, there is evidence that Ca may negatively affect the absorption of other critical micronutrients, particularly Fe. The objective this randomised, double-blind, placebo-controlled trial was to determine whether providing 2000 mg/d 25µg/d vitamin in a fortified food product 9 weeks affects Fe status young adults. Male ( n 98) female 54) volunteers...