A5087281391- Parathyroid Disorders and Treatments
- Bariatric Surgery and Outcomes
- COVID-19 and healthcare impacts
- Thyroid and Parathyroid Surgery
- Cancer Research and Treatments
- Esophageal and GI Pathology
- Body Contouring and Surgery
- COVID-19 Clinical Research Studies
- interferon and immune responses
- Medical Imaging and Pathology Studies
- Esophageal Cancer Research and Treatment
- Autophagy in Disease and Therapy
- Pancreatic and Hepatic Oncology Research
- Gastric Cancer Management and Outcomes
- Enhanced Recovery After Surgery
- Thyroid Cancer Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Retinoids in leukemia and cellular processes
- Hepatocellular Carcinoma Treatment and Prognosis
- Intestinal and Peritoneal Adhesions
- Animal testing and alternatives
- Veterinary Pharmacology and Anesthesia
- Dermatological and Skeletal Disorders
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
Hôpital Civil, Strasbourg
2020-2022
Institut de Recherche contre les Cancers de l’Appareil Digestif
2009-2021
Université de Strasbourg
2009-2021
Institut de Chirurgie Guidée par l'Image
2016-2021
Hôpitaux Universitaires de Strasbourg
2016
Institut de génétique et de biologie moléculaire et cellulaire
2008-2011
Inserm
2007
Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed vaccinate (NNV) prevent one COVID-19-related death in 1 year. NNVs were based on postoperative rates and mortality an international cohort (surgical patients), community incidence case fatality data (general population). NNV estimates stratified age (18–49,...
SARS-CoV-2 has been associated with an increased rate of venous thromboembolism in critically ill patients. Since surgical patients are already at higher risk than general populations, this study aimed to determine if peri-operative or prior were further thromboembolism. We conducted a planned sub-study and analysis from international, multicentre, prospective cohort elective emergency undergoing surgery during October 2020. Patients all specialties included. The primary outcome measure was...
TRIM24 (TIF1α), TRIM28 (TIF1β), and TRIM33 (TIF1γ) are three related cofactors belonging to the tripartite motif superfamily that interact with distinct transcription factors. interacts liganded retinoic acid (RA) receptor repress its transcriptional activity. Germ line inactivation of in mice deregulates RA-signaling hepatocytes leading development hepatocellular carcinoma (HCC). Here we show can be purified as at least two macromolecular complexes comprising either or TRIM28. Somatic...
Abstract Background Robust data on quality of life (QoL) after different techniques bariatric surgery are sparse. This RCT compared excess weight loss (EWL) and QoL sleeve gastrectomy versus Roux-en-Y gastric bypass (RYGB). Methods Obese patients were assigned randomly to RYGB or gastrectomy. The primary outcome measure was EWL. Secondary outcomes included QoL, co-morbidity, adverse events, vitamin glycolipid status. assessed before annually surgery, using the Moorehead–Ardelt Quality Life...
The present retrospective study evaluates the diagnostic value of integrated 18F-Fluorocholine positron emission tomography/four-dimensional contrast-enhanced computed tomography (18F-FCH PET/4D-CT) as second-line imaging in preoperative work-up primary hyperparathyroidism (pHPT), and compares 18F-FCH PET with 4D-CT. Patients pHPT negative/discordant first-line addressed for PET/4D-CT were retrospectively selected. Sensitivity detection rate (DR%) PET/CT, 4D-CT, calculated according to per...
Abstract The development of multimodal strategies for the treatment hepatocellular carcinoma requires tractable animal models allowing advanced in vivo imaging. Here, we characterize an orthotopic model based on injection luciferase-expressing human hepatoma Huh-7 (Huh-7-Luc) cells immunodeficient mice. Luciferase allows easy repeated monitoring tumor growth by bioluminescence. intrahepatic was more efficient than intrasplenic or intraportal terms survival, rate engraftment, and easiness. A...
Patients with primary hyperparathyroidism (pHPT) can develop persistent (P-pHPT) or recurrent (R-pHPT) disease after parathyroidectomy. Before recommending reoperation, recurrence must be accurately identified because of the high risk complications. Our study evaluates 18F-fluorocholine (18F-FCH) PET/CT and 4D-CT integrated in PET/4D-CT patients P-pHPT/R-pHPT. P-pHPT/R-pHPT investigated by 18F-FCH between May 2018 March 2021 were retrospectively included. Forty-two included, 37 whom...
Calcification of arteries is a major risk factor for cardiovascular mortality in humans. Using genetic approaches, we demonstrate here that the transcriptional intermediary 1alpha (TIF1alpha), recently shown to function as tumor suppressor murine hepatocytes, also participates molecular cascade prevents calcifications arterioles and medium-sized arteries. We further provide evidence this TIF1alpha not exerted hepatocytes. The sites ectopic mutant mice lacking resemble those seen carrying an...
Genetically induced hepatocellular carcinoma (HCC) models are generally used to investigate carcinogenesis pathways, but very few attempts were made valorize them for pharmacological testing. This study describes a micro-computed tomography (micro-CT) - based methodology the diagnostic and lifelong follow-up of HCC in hepatocyte-specific Trim24-null mouse line. Myo-inositol trispyrophosphate (ITPP) was tested as anti-cancer drug.Partial hepatectomy performed 2 months-old mice, order...
Intraoperative decision of the level distal resection in rectal cancer is often imprecise, based exclusively on digital examination and pretherapeutic imaging.Prospective, single institution, nonrandomized trial ( ClinicalTrial.gov identification no. NCT01887509) to evaluate contribution probe-based confocal laser endomicroscopy (pCLE) establish optimal margin adenocarcinoma. The primary outcome was concordance lower tumor margins between pCLE histopathology. For each patient, performed...
Frozen section is the standard method to histologically distinguish parathyroid tissue from thyroid during endocrine neck surgery. can be time-consuming and costly. Its drawback that it performed only after removal of a suspected pathological tissue. This study demonstrates use probe-based confocal laser endomicroscopy (pCLE) confirm histology prior resection.A prospective, single-institution, nonrandomized was conducted. No sample size calculation for this observational trial. The primary...
Introduction. Connected systems transmitting vital parameters could well represent a tool to shorten postoperative hospital stay while providing continuous remote patient monitoring and potentially detect the onset of complications. Our aim was analyze functionality transcutaneous biosensing data collection patch in morbidly obese patients. Materials Methods. An adhesive (The HealthPatch MD™) applied patients’ chests postoperatively. The connected tablet via bluetooth network collect heart...
Purpose Thyroid nodules frequently coexist with primary hyperparathyroidism (pHPT). Because of the increasing use 18 F-fluorocholine ( F-FCH) PET/CT in patients pHPT, evaluation its clinical utility for thyroid characterization this population is paramount importance. Herein, we investigate value dual-point F-FCH diagnosis cancer referred pHPT imaging who have nodules. Patients and Methods All underwent a dual-time point (at 5 60 minutes postinjection) between July 2019 December 2020 were...
Objective. Preoperative imaging in primary hyperparathyroidism (PHPT) is essential for planning of parathyroidectomy-particularly selection a minimally invasive approach. The objective this cohort study was to evaluate the diagnostic precision 3D virtual neck exploration (3D-VNE), its impact on choice surgical approach, and document correlation with long-term outcomes. Methods. 235 consecutive patients PHPT were studied (January 2014 December 2018), 6-month follow-up. 220 had preoperative...