A5041458627- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Child Development and Digital Technology
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Virology and Viral Diseases
- Child Nutrition and Feeding Issues
- Neuroendocrine regulation and behavior
- Neural and Behavioral Psychology Studies
- Functional Brain Connectivity Studies
- Attention Deficit Hyperactivity Disorder
- Family and Disability Support Research
- Evolutionary Psychology and Human Behavior
- Obesity, Physical Activity, Diet
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Behavioral and Psychological Studies
- Health and Medical Studies
- School Health and Nursing Education
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Complementary and Alternative Medicine Studies
- Childhood Cancer Survivors' Quality of Life
- Mental Health and Psychiatry
- Adolescent and Pediatric Healthcare
- Neuroscience of respiration and sleep
- Obsessive-Compulsive Spectrum Disorders
Justus-Liebig-Universität Gießen
2024
Technical University of Darmstadt
2024
Philipps University of Marburg
2017-2023
Klinik und Poliklinik für Kinder- und Jugendpsychiatrie
2019-2023
Heinrich Heine University Düsseldorf
2009-2015
Universität Ulm
2008-2010
Exercise seems a simple and widely practised behaviour that activates molecular cellular signalling cascades involved in various central nervous system processes. Despite impressive results obtained animal studies, fitness interventions have produced less reliable effects humans, particularly young adults. In the present study we tested hypothesis an individually adapted exercise training consisting of three running sessions 30 minutes per week for 6 weeks, has potential to improve...
Abstract Diagnosing autism spectrum disorders (ASD) is a complicated, time-consuming process which particularly challenging in older individuals. One of the most widely used behavioral diagnostic tools Autism Diagnostic Observation Schedule (ADOS). Previous work using machine learning techniques suggested that ASD detection children can be achieved with substantially fewer items than original ADOS. Here, we expand on this specific focus adolescents and adults as assessed ADOS Module 4. We...
Autism spectrum disorder (ASD) is characterized as a very heterogeneous child-onset disorder, whose heterogeneity partly determined by differences in intelligence quotient (IQ). Older epidemiological studies suggested that the IQ-related tends to be skewed left, i.e., larger proportion of individuals with ASD have below average intelligence, while only few may an IQ above average. This picture changed over time broadening view. Within present perspective article, we discuss discrepancies...
Impairments in facial affect recognition are well documented individuals suffering from schizophrenia. The aim of the present study was to characterize potential impairments and their electrophysiological correlates at-risk individuals. Such characterization should add question whether neural processes underlying deficits might be part a basic dysfunction reflecting vulnerability factor schizophrenia.To test recognition, digitized series pictures affect, previously used related studies,...
Early identification of autism spectrum disorders (ASD) is a prerequisite for access to early interventions. Although parents often note developmental atypicalities during the first 2 years life, many children with ASD are not diagnosed until school age. For parents, long period between parental concerns and diagnosis frustrating accompanied by uncertainty worry.This study retrospectively explored trajectories confirmed diagnostic process, from about their child's development definite...
Autism Spectrum Disorder (ASD) is a severe, lifelong neurodevelopmental disorder with early onset that places heavy burden on affected individuals and their families. Due to the need for highly specialized health, educational vocational services, ASD cost-intensive disorder, strain health care systems increases increasing age of individual. The ASD-Net will study Germany's largest cohort patients over lifespan. By combining methodological expertise from all levels clinical research, follow...
Background Diagnostic assessment of ASD requires substantial clinical experience and is particularly difficult in the context other disorders with behavioral symptoms domain social interaction communication. Observation measures such as Autism Schedule (ADOS) do not take into account co‐occurring disorders. Method We used a well‐characterized sample individuals ( n = 1,251) that had received detailed outpatient evaluation for presence an diagnosis 481) covered range additional overlapping...
Complementary and Alternative Medicine (CAM) is widely used both in the general population for treatment of somatic psychiatric disorders. Studies on CAM use among patients with autism spectrum disorder (ASD) have so far only focused children adolescents. The aim this study was to investigate patterns adults ASD. A questionnaire survey concerning current lifetime distributed ASD between November 2015 June 2016. Participants diagnosed by experienced clinicians using diagnostic gold standard...
Diagnosing autism spectrum disorder (ASD) requires extensive clinical expertise and training as well a focus on differential diagnoses. The diagnostic process is particularly complex given symptom overlap with other mental disorders high rates of co-occurring physical health concerns. aim this study was to conduct data-driven selection the most relevant information collected from behavior observation an anamnestic interview in two samples children/younger adolescents adolescents/adults...
Violent offenders with schizophrenia have a particularly poor performance level in facial affect recognition.Nineteen male patients, who had been committed to psychiatric hospital detention because of violent offences and lack criminal responsibility, were recruited receive the Training Affect Recognition (TAR). Performance Pictures Facial (PFA)-test event-related potentials (ERPs) registered pre–post-treatment design.TAR was feasible very high treatment effect (Cohen's d = 1.88), which...
Evidence suggests that intranasal application of oxytocin facilitates empathy and modulates its underlying neural processes, which are often impaired in individuals with autism spectrum disorders (ASD). Oxytocin has therefore been considered a promising candidate for the treatment social difficulties ASD. However, evidence linking to behavior brain function ASD is limited heterogeneous effects might depend on variations oxytocin-receptor gene (OXTR). We examined 25 male patients without...
We investigated whether male inpatients with schizophrenia and a history of hands-on violent offences (forensic schizophrenic, FOS) are more impaired in emotion recognition than matched patients without any violence (general psychiatric GPS). This should become apparent performance psychometry scalp event-related brain potentials (ERPs) evoked by pictures facial affect. FOS GPS (each n = 19) were concerning age, intelligence, comorbid addiction, medication illness duration. revealed...
Abstract International studies show disadvantages for adults with autism spectrum disorder (ASD) in the labor market. Data about their participation German market are scarce. The aim of this study was to examine integration ASD terms education, employment and type occupation by means a cross-sectional-study, using postal questionnaire. Findings above average levels education compared general population Germany simultaneously, below rates high financial dependency. That indicates poor...
Symptoms of mood and anxiety disorders overlap with symptoms autism spectrum disorder, making the diagnostic process challenging. This study found that a combination communicational deficits unusual and/or inappropriate social overtures facilitates differentiation between disorder disorders. Furthermore, results confirm essential need behavioral observation Autism Diagnostic Observation Schedule in full Interview-Revised to support decisions.
This study aimed to build on the relationship of well-established self-report and behavioral assessments latent constructs positive (PVS) negative valence systems (NVS), cognitive (CS), social processes (SP) Research Domain Criteria (RDoC) framework in a large transnosological population which cuts across DSM/ICD-10 disorder criteria categories. One thousand four hundred thirty one participants (42.1% suffering from anxiety/fear-related, 18.2% depressive, 7.9% schizophrenia spectrum, 7.5%...
Although autism spectrum disorder (ASD) is a relatively common, well-known but heterogeneous neuropsychiatric disorder, specific knowledge about characteristics of this heterogeneity scarce. There consensus that IQ contributes to as well complicates diagnostics and treatment planning. In study, we assessed the accuracy Autism Diagnostic Observation Schedule (ADOS/2) in whole IQ-defined subsamples, analyzed if ADOS/2 may be increased by application machine learning (ML) algorithms processed...
Autism spectrum disorders (ASD) are associated with high services use, but European data on costs scarce. Utilisation and annual of 385 individuals ASD (aged 4-67 years; 18.2% females; 37.4% IQ < 85) from German outpatient clinics were assessed. Average per person 3287 EUR, psychiatric inpatient care (19.8%), pharmacotherapy (11.1%), occupational therapy (11.1%) being the largest cost components. Females incurred higher than males (4864 EUR vs. 2936 EUR). In a regression model, female sex...
Parent-child relationship is developed and changed through reciprocal interactions between a child his/her parent, these can strongly influence the child's development across domains (e.g., emotional, physical, intellectual). However, little known about parental perception of contribution to dyadic parent-child in terms positive negative behaviors. We therefore aimed develop validate an economical parent-report instrument assess important aspects. The validation study included 1642 mothers (M