Abhishek Sharma

ORCID: 0000-0002-0271-6892
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Research Areas
  • Plant tissue culture and regeneration
  • Transgenic Plants and Applications
  • Plant Genetic and Mutation Studies
  • Microbial Natural Products and Biosynthesis
  • Alkaloids: synthesis and pharmacology
  • Plant biochemistry and biosynthesis
  • Nanoparticles: synthesis and applications
  • Plant-Microbe Interactions and Immunity
  • Semantic Web and Ontologies
  • Berberine and alkaloids research
  • Seed Germination and Physiology
  • Microbial infections and disease research
  • Plant and animal studies
  • Aquaculture disease management and microbiota
  • Natural product bioactivities and synthesis
  • Bacteriophages and microbial interactions
  • Antibiotic Use and Resistance
  • Photosynthetic Processes and Mechanisms
  • Nanotechnology research and applications
  • Free Radicals and Antioxidants
  • Microbial Metabolic Engineering and Bioproduction
  • Antibiotic Resistance in Bacteria
  • Chemical synthesis and alkaloids
  • Medicinal Plants and Neuroprotection
  • Biological and pharmacological studies of plants

Indian Institute of Advanced Research
2022-2025

Uka Tarsadia University
2019-2024

Punjab Engineering College
2023

Institute of Medical Sciences
2023

Government Medical College, Amritsar
2023

Indira Gandhi Medical College
2023

Ahmedabad Civil Hospital
2023

Dr. Rajendra Prasad Government Medical College
2023

Sree Balaji Dental College and Hospital
2023

Czech Academy of Sciences, Institute of Biotechnology
2022

Introduction Klebsiella pneumonia is one of the most prevalent bacteria that cause nosocomial infections, particularly in critically ill patients intensive care unit (ICU). Multi-drug-resistant pneumoniae (MDRKP) has become an urgent risk to public health as its prevalence sharply surged around globe recent decades. Therefore, this research was conducted evaluate shifts over a four-year period drug susceptibility patterns among isolates from mechanically ventilated patients. Materials and...

10.7759/cureus.36317 article EN Cureus 2023-03-17

Orchids constitute the largest and most diverse group of flowering plants are classified in family Orchidaceae. Exhibiting significance as exotic ubiquitous plant, cultivation orchids on a commercial level is gaining momentum worldwide. In addition to its ornamental aesthetic value, orchid industry has successfully generated employment for people developing countries. Recent advances biotechnological interventions have substantially contributed development varieties with novel traits, not...

10.3390/horticulturae10020152 article EN cc-by Horticulturae 2024-02-06

Transgenic Catharanthus roseus plants (transgenic Dhawal [DT] and transgenic Nirmal [NT]) obtained from the Agrobacterium tumefaciens rhizognenes-mediated transformations, respectively, have been maintained in vitro for 5 years. Plants were studied at regular intervals various parameters such as plant height, leaf size, multiplication rate, alkaloid profile presence of marker genes. DT gradually lost GUS gene expression it was not detected fifth year while NT demonstrated genes rolA, rolB...

10.1080/14786419.2014.940348 article EN Natural Product Research 2014-08-07

Catharanthus roseus synthesizes bioactive therapeutic metabolites, known as monoterpenoid indole alkaloids (MIAs), including antineoplastic vinblastine and vincristine, which have high global demand, antihypertensive ajmalicine, a serpentine. However, the in planta biosynthesis accumulation of these phytopharmaceuticals are very low, attributed to their cytotoxicity plant. Considering low concentration over-harvesting plant resources, biotechnological interventions been undertaken enhance...

10.3390/plants11212885 article EN cc-by Plants 2022-10-28

The emerging outbreak of infectious diseases poses a challenge and threatens human survival. indiscriminate use drying pipelines antibiotic arsenals have led to the alarming rise drug-resistant pathogens, projecting serious concern. rising antimicrobial resistance redundancy discovery platforms (ADPs) highlighted growing concern discover new antibiotics, necessitating exploring natural products as effective alternatives counter drug resistance. Recently, plants been extensively investigated...

10.2174/1568026622666220310104645 article EN Current Topics in Medicinal Chemistry 2022-03-11

In this study, a gold nanoparticles (GNPs) have been successfully fabricated by the bio reduction route using soil extract Aspergillus trinidadensis (VM ST01' OL587588) fungi as reducing and capping agent without any solvent interference. The GNPs were grown stabilized two-step one-pot method, influence of chemical reactants. Characteristics prepared investigated various microscopic spectroscopic techniques. roughly spherical in shape. Water dispersion study has shown stable broad range 2–12...

10.1016/j.tgchem.2023.100021 article EN cc-by-nc-nd Tetrahedron Green Chem 2023-08-03

Abstract Orchids constitute the largest and most diverse group of flowering plants are classified in Orchidaceae. Exhibiting significance as exotic ubiquitous plants, cultivation orchids on a commercial level, is gaining momentum worldwide. In addition to its ornamental aesthetic value, orchid industry has been successful generating employment for people developing countries. Recent advances biotechnological interventions have substantially contributed development varieties with novel...

10.21203/rs.3.rs-1382018/v1 preprint EN cc-by Research Square (Research Square) 2022-03-01

Abstract: The rising statistics of antimicrobial resistance pose an alarming concern for the mankind. extensive/injudicious use antibiotics in environment, animal husbandry, and health care have led to rise infectious microbes developing against conventional drugs. phytotherapeutics defines attractive approach tackling drug-resistant microbes, attributed their ability target major mechanisms, including efflux pumps, biofilms, cell membranes, among others. In recent times, discovery...

10.2174/1570180819666220620102427 article EN Letters in Drug Design & Discovery 2022-06-21

The rising incidence of human diseases has necessitated the exploration alternative sources medications, with a refocus and plant-based metabolites demonstrating pharmacological attributes. Catharanthus roseus (L.) G. Don, popularly known as Madagascar Periwinkle, constitutes an attractive source monoterpene indole alkaloids (MIAs), vincristine, vinblastine analogs efficacy in treatment multiple disorders. Considering emerging prospects global demands C. alkaloids, thematic review provides...

10.1016/j.sajb.2022.09.039 article EN cc-by South African Journal of Botany 2022-10-03

Scientific progress in a domain depends greatly on making use of results previous research activities. Like human beings, it is difficult for computers to encode and retrieve the unsupervised Web information. The basic answer this problem describe information explicitly semantically with ontology. article presents brief discussion study undertaken design an ontology Nanotechnology field.Scientific expanding web Nanotechnology, which was developed by using Resource Description Framework...

10.14429/djlit.36.1.9198 article EN DESIDOC Journal of Library & Information Technology 2016-01-22
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