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Julia Freund

ORCID: 0000-0002-0279-556X
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About
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A5052841736
Research Areas
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 and COVID-19 Research
  • Virus-based gene therapy research

Universitätsmedizin Göttingen
 2021

 The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models
OPENALEX - Publications 
Kim M. Stegmann Antje Dickmanns Sabrina Gerber Vella Nikolova Luisa Klemke and 13 more Valentina Manzini Denise Schlösser Cathrin Bierwirth Julia Freund Maren Sitte Raimond Lugert Gabriela Salinas Toni Luise Meister Stephanie Pfaender Dirk Görlich Bernd Wollnik Uwe Groß Matthias Dobbelstein

10.1016/j.virusres.2021.198469 article EN Virus Research 2021-06-06
 The folate antagonist methotrexate diminishes replication of the coronavirus SARS-CoV-2 and enhances the antiviral efficacy of remdesivir in cell culture models
OPENALEX - Publications 
Kim M. Stegmann Antje Dickmanns Sabrina Gerber Vella Nikolova Luisa Klemke and 11 more Valentina Manzini Denise Schlösser Cathrin Bierwirth Julia Freund Maren Sitte Raimond Lugert Gabriela Salinas Dirk Görlich Bernd Wollnik Uwe Groß Matthias Dobbelstein

ABSTRACT The search for successful therapies of infections with the coronavirus SARS-CoV-2 is ongoing. We tested inhibition host cell nucleotide synthesis as a promising strategy to decrease replication SARS-CoV-2-RNA, thus diminishing formation virus progeny. Methotrexate (MTX) an established drug cancer therapy and induce immunosuppression. inhibits dihydrofolate reductase other enzymes required nucleotides. Strikingly, was inhibited by MTX in therapeutic concentrations around 1 μM,...

10.1101/2020.07.18.210013 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2020-07-20
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