China has pledged to peak carbon emissions by 2030 and neutralize 2060. There is an urgent need develop a comprehensive reliable methodology judge whether region reached its (CEP), as well schedule prioritize mitigation activities for different regions. In this study, we developed approach identifying the CEP status of 30 provincial areas in China, considering both trends main socioeconomic factors that influence these trends. According results Mann-Kendall (MK) tests, changes can be grouped...

<title>Abstract</title> Microglia are specialized resident immune cells of the central nervous system parenchyma that mediate reactions such as inflammatory response to spinal cord injury (SCI) and play significant roles in exacerbating or alleviating disease progression. Previous studies have suggested ferroptosis, a newly discovered form regulated necrotic cell death, plays crucial role neuronal dysfunction loss following SCI; however, microglial ferroptosis SCI underlying mechanisms...

Phobic anxiety present after stroke (called poststroke anxiety, PSA) can hamper the rehabilitation of patients and disrupt their usual activities. Besides, symptoms mechanisms PSA are different from those in nonstroke populations that have generalized disorder. What's more, treatment approaches for phobic confined to unitary or general methods with poor efficiency.

Commercial chemicals, such as synthetic musks, are of global concern, but data on their occurrence and spatial distribution in aquatic environments large scale scarce. Two sampling campaigns were conducted the present study to measure freely dissolved musks freshwaters across China using passive samplers, along with biological coexposure at selected sites. Polycyclic (PCMs) dominated a detection frequency 95%. Higher concentrations PCMs observed densely populated Mid, East, South compared...

This work reports on surface acoustic wave (SAW) piezoelectric resonators with high quality factor (Q) based high-crystallinity aluminum scandium nitride (AlScN) thin films. The properties of modes were analyzed using finite element modeling (FEM) simulations. SAW different AlScN composite substrates fabricated and measured. Due to good crystallinity (FWHM < 1°) the film, over 1000 has been demonstrated AlScN/AlN/sapphire substrate, which proves sapphire substrate is a candidate enable <tex...

The goal of this study was to investigate how realistic changes in medial surface shape, as occur human phonation, affect voice production. In a parametric magnetic resonance imaging-based three-dimensional vocal fold model, the superior and inferior portions were systematically manipulated produce different contours similar those observed previous excised larynx vivo canine experiments. Voice simulations performed differences resulting results showed that both superior-medial bulging...

This paper introduces a parametric three-dimensional body-cover vocal fold model based on magnetic resonance imaging (MRI) of the human larynx. Major geometric features that are observed in MRI images but missing current models discussed, and their influence vibration is evaluated using eigenmode analysis. Proper boundary conditions for also discussed. Based control parameters corresponding to anatomic landmarks can be easily measured, this adapted toward subject-specific voice production...

Cerebral ischemia reperfusion (I/R) is a therapeutic strategy for ischemia; however, it usually causes injury by the aspect of inflammation and neuron apoptosis. This investigation aims to investigate protective effects phytic acid (IP6) cerebral I/R in vitro. PC-12 cells under Oxygen glucose deprivation/reperfusion (OGD/R) were performed mimic I/R. IP6 was pretreated before OGD/R treatment. The data showed that activated expression sestrin2 injured cells. inhibited induced inflammation,...

Dual-frequency ultrasound has been widely employed to enhance and regulate acoustic droplet vaporization (ADV) but the role of ultrasonic nonlinear effects on it remains unclear. The main objective this study is investigate influence control ADV nucleation under different dual-frequency focused conditions. PFC nanodroplets activated by was modeled parametric studies were conducted frequency power degree nonlinearity (DoN), rates dimensions region in a wide parameter range. results showed...

Vibration of vocal folds is a body-cover layered vibration pattern due to the two-layer tissue structures folds. A method based on synchronal imaging system proposed in order image and measure This contains two parts: high-frame-rate ultrasonic part high-speed video part, which can synchronously body cover layers at high speed. Then, analysis methods are applied from both recorded sequences. We analyze characteristics body-layer measurements designed experiments. Moreover, these results meet...

Glottal insufficiency due to vocal fold paralysis, paresis, or atrophy often leads degraded voice quality. One of the primary surgical intervention procedures treat glottal is medialization laryngoplasty, in which an implant inserted through a lateral window on thyroid cartilage medialize folds. While goal modify structure restore normal phonation, few studies have attempted quantify such structural changes The this study three-dimensional folds insertion and evaluate its potential effect...

Spinal cord injury (SCI) is a common cause of disability, which often leads to sensorimotor cortex dysfunction above the spinal site. However, cerebral regional effects on metabolic information after SCI have been little studied. Here, adult Sprague-Dawley rats were divided into acute and chronic treatment groups sham with day-matched periods. The Basso, Beatte, Bresnahan scores method utilized evaluate changes in behaviors during recovery animals, was measured 1H-observed/13C-edited NMR...

Electrolarynx (EL) is a medical speech-recovery device designed for patients who have lost their original voice box due to laryngeal cancer. As substitute human larynx, the current commercial EL source cannot reconstruct natural speech under laryngectomy conditions. To eliminate abnormal acoustic properties of speech, supraglottal with compensation vocal tract characteristics was proposed and provided through an experimental EL(SGVS-EL) system. The analyses simulated reconstructed produced...

While vocal fold dehydration is often considered an important factor contributing to fatigue, it still remains unclear whether vibration alone able induce severe that has a noticeable effect on phonation and perceived effort. A three-dimensional model was developed investigate systemic surface during phonation. Based the linear poroelastic theory, water resupply from blood vessels through lateral boundary, movement within folds, exchange between folds liquid layer epithelium, fluid...

Objective: The present study sought to detect spinal sirtuin 1 (SIRT1) and acetylation of histone H3 (Ac-H3) expression in rats with burn injury pain (BIP model). Procedures Results: A BIP model was first established. showed lower paw withdrawal threshold (PWT) from day 1, which persisted for 21 days following the injury. Spinal SIRT1/Ac-H3 increased intrathecal use resveratrol PWT SIRT1 but induced down-regulation Ac-H3 expression. We demonstrated that inhibition significantly mechanical...

For the purpose of noninvasively visualizing dynamics contact between vibrating vocal fold medial surfaces, an ultrasonic imaging method which is referred to as array-based transmission glottography proposed. An array ultrasound transducers used detect wave transmitted from one side folds other through small-sized folds. A passive acoustic mapping employed visualize and locate contact. The results investigation using tissue-mimicking phantoms indicate that it feasible use proposed soft...

Radiated noise severely degrades the electrolarynx (EL) speech. It cannot be thoroughly suppressed by conventional frequency-domain enhancement methods. In this paper, a new method, called multiband time-domain amplitude modulation (MTAM), is proposed to reduce radiated of EL speech components changing slowly that represent are removed directly modulating amplitudes in multiple frequency bands. The enhanced MTAM and methods (spectral subtraction Wiener filtering) evaluated on both acoustic...