A5101527127- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Ion channel regulation and function
- Neuropeptides and Animal Physiology
- Nausea and vomiting management
- Sirtuins and Resveratrol in Medicine
- Anesthesia and Sedative Agents
- Cancer, Stress, Anesthesia, and Immune Response
- Nutrition and Health in Aging
- Electrospun Nanofibers in Biomedical Applications
- Axon Guidance and Neuronal Signaling
- Pharmacological Receptor Mechanisms and Effects
- Engineering and Test Systems
- Histone Deacetylase Inhibitors Research
- Glycogen Storage Diseases and Myoclonus
- Advanced Algorithms and Applications
- Clinical Nutrition and Gastroenterology
- Intensive Care Unit Cognitive Disorders
- Treatment of Major Depression
- Cancer survivorship and care
- Tropical and Extratropical Cyclones Research
- Thyroid Disorders and Treatments
- Plant-based Medicinal Research
- Hydrogels: synthesis, properties, applications
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Shanxi Academy of Medical Sciences
2024
Shanxi Medical University
2024
Southern Medical University
2024
Xuzhou Medical College
2009-2023
Huaian First People’s Hospital
2023
Nanjing Medical University
2023
People's Hospital of Xinjiang Uygur Autonomous Region
2015-2020
Affiliated Hospital of Xuzhou Medical College
2009-2016
Background The NF-κB pathway and chemokine (C-C motif) ligand 5 (CCL5) are involved in pain modulation; however, the precise mechanisms of their interactions chronic neuropathic have yet to be established. Methods present study examined roles spinal CCL5 a model after constriction injury (CCI) surgery. CCI-induced facilitation was evaluated using Plantar von Frey tests. changes expression were analyzed by immunohistochemistry Western blot analyses. Results Spinal increased CCI Repeated...
At present, most of the drugs have little effect on pathological process rheumatoid arthritis (RA). Analgesia is an important measure in treatment RA and also one criteria to determine therapeutic effects disease. Some studies found that crocin, a kind Chinese medicine, can effectively alleviate pain sensitization model rats, but mechanism not clear. Emerging evidence indicates crocin may inhibit metastasis lung liver cancer cells from breast by inhibiting Wnt/ β -catenin Wnt signaling...
Abstract The implication of 5-hydroxytryptamine 2C receptor (5-HT2CR) activity in depression is a topic debate, and the underlying mechanisms remain largely unclear. Here, we elucidate how hippocampal excitation-inhibition (E/I) balance underlies regulatory effects 5-HT2CR depression. Molecular biological analyses showed that chronic mild stress (CMS) reduced expression hippocampus. We revealed inhibition induced depressive-like behaviours, GABA release shifted E/I towards excitation CA3...
Probiotic Lactobacillus plantarum BFS1243 improved gut dysbiosis and then decreased systemic inflammation, ultimately improving frailty-associated phenotypes to varying degrees, which were caused by transplantation of fecal microbiota from frailty patients.
Dressings play a crucial role in the management of burn wounds. In this study, cotton bandages were modified with poly (N-isopropylacrylamide)/graphite oxide/nano silver (PNIPAM/GO-Ag) hydrogel to obtain novel dressing (PNIPAM/GO-Ag/COT). The healing effect PNIPAM/GO-Ag/COT on deep second-degree wounds rats and changes related inflammatory factors explored analyzed systematically. model was established by steam scald method Sprague-Dawley (SD) rats. granulation tissue, collagen deposition,...
The present study examined the effects of intrathecal use resveratrol on pain hypersensitivities, spinal glia activation, and CX3CR1 expression in model bone cancer (BCP). BCP was established through intrathecally injecting Walker 256 mammary gland carcinoma cells to Sprague-Dawley rats. We found that glial activation aggravated after inoculation. Resveratrol (i.t.) attenuated cancer-induced decreased spine a model. also mechanical allodynia resulting from fractalkine Inhibition upregulation...
Objective: The present study sought to detect spinal sirtuin 1 (SIRT1) and acetylation of histone H3 (Ac-H3) expression in rats with burn injury pain (BIP model). Procedures Results: A BIP model was first established. showed lower paw withdrawal threshold (PWT) from day 1, which persisted for 21 days following the injury. Spinal SIRT1/Ac-H3 increased intrathecal use resveratrol PWT SIRT1 but induced down-regulation Ac-H3 expression. We demonstrated that inhibition significantly mechanical...
Objective To evaluate the effects of combination lightwand and direct laryngoscope on heart rate variability (HRV) in tracheal intubation.Methods Elective eighty patients scheduled for general anaesthesia with intubation were randomly divided into two groups:the group (group A,n=40) laryngoscop group(group B,n=40).The HRV analyzed power spectrum before induction(T0) after induction(T1),at trachea intubation(T2),1 min(T3) 5 min(T4) measured.The rate(HR),the systolic blood pressure (SBP)...
The present study was designed to investigate the role of spinal neuronal nicotinic acetylcholine receptors in analgesic effects isoflurane. After having established mice model analgesia by intraperitoneally injecting (i.p.) appropriate doses isoflurane, nicotine, a receptor agonist intrathecally injected. isoflurane and nicotine on paw licking times formalin-induced c-fos expression cord dorsal horn were examined. Our correlative studies have shown that can decrease simultaneously suppress...
Objective To investigate the relationship between GABA_A receptor and hypnotic effects of pentobarbital sodium,sodium hydroxybutyrate, etomidate, propofol ketamine. Methods After having established mice model hypnosis by intraperitoneally injected appropriate doses sodium, sodium or ketamine, we intracerebroventricularly intravenously with different bieuculline (Bic) seeurinine (Se); then observed on sleeping time using awaken test. Results Bic Se significantly dose-dependently decreased...
Background Opioids and its regulatory mechanism are hot spots in the study of immune regulation. It is very important to interactions among different kinds cells tissues, which have dual character regulating immunity. Objective The latest progress system mu receptor for treatment cancer pain taken into account providing a new strategy tumor regulation. Content Recent studies found that opioids their downstream targets involved regulation development diseases, especially opioid...
Objective To investigate the effects of dexmedetomidine (Dex) combined with dezocine in patient-controlled intravenous analgesia (PCIA) on sleep quality, pain scores and adverse reactions patients undergoing laparoscopic assisted vaginal hysterectomy. Methods Sixty who underwent hysterectomy were randomly divided into two groups(n=30): a group(group C) Dex+dezocine D). The primary observation indicators distribution different periods sleep[rapid eye movement(REM) non REM(M1, M2, M3)...