A5086150895- Invertebrate Immune Response Mechanisms
- Mosquito-borne diseases and control
- Insect symbiosis and bacterial influences
- Insect and Arachnid Ecology and Behavior
- Hippo pathway signaling and YAP/TAZ
- Entomological Studies and Ecology
- Heat shock proteins research
- Neurobiology and Insect Physiology Research
- Transgenic Plants and Applications
- CRISPR and Genetic Engineering
- Animal Behavior and Reproduction
- Developmental Biology and Gene Regulation
- Insect and Pesticide Research
- Trypanosoma species research and implications
- Insect behavior and control techniques
- Viral Infections and Vectors
- Sperm and Testicular Function
University of Massachusetts Chan Medical School
2020-2022
Johns Hopkins University
2014-2017
Stanford University
2011-2013
Transmission of dengue virus (DENV) requires successful completion the infection cycle in Aedes aegypti vector, which is initiated midgut tissue after ingestion an infectious blood meal. While certain Ae. midgut-associated bacteria influence infection, little known about fungi (mycobiota), and how its members might susceptibility to DENV infection. We show that a Talaromyces (Tsp_PR) fungus, isolated from field-caught aegypti, render mosquito more permissive This modulation attributed...
Specialized microenvironments, or niches, provide signaling cues that regulate stem cell behavior. In the Drosophila testis, JAK-STAT pathway regulates germline (GSC) attachment to apical hub and somatic cyst (CySC) identity. Here, we demonstrate chickadee, gene encodes profilin, is required autonomously maintain GSCs, possibly facilitating localization maintenance of E-cadherin GSC-hub interface. Germline specific overexpression Adenomatous Polyposis Coli 2 (APC2) rescued GSC loss in chic...
Dengue virus host factors (DENV HFs) that are essential for the completion of infection cycle in mosquito vector and vertebrate represent potent targets transmission blocking. Here we investigated whether known mammalian DENV HF inhibitors could influence arthropod A. aegypti. We evaluated potency bafilomycin (BAF; inhibitor vacuolar H+-ATPase (vATPase)), mycophenolic acid (MPA; inosine-5′-monophosphate dehydrogenase (IMPDH)), castanospermine (CAS; glucosidase), deoxynojirimycin (DNJ;...
Drosophila Toll-1 and all mammalian Toll-like receptors regulate innate immunity. However, the functions of remaining eight Toll-related proteins in are not fully understood. Here, we show that Toll-9 is necessary sufficient for a special form compensatory proliferation after apoptotic cell loss (undead apoptosis-induced [AiP]). Mechanistically, AiP, interacts with to activate intracellular pathway nuclear translocation NF-κB-like transcription factor Dorsal, which induces expression...
Drosophila melanogaster males express two primary cuticular hydrocarbons (male-predominant hydrocarbons). These act as sex pheromones by influencing female receptivity to mating. The relative quantities of these vary widely among natural populations and can contribute variation in mating success. We tested four isofemale lines collected from a wild population assess the effect intrapopulation male-predominant on laboratory females wild-caught varied significantly, but not consistently...
Abstract The initiator caspase Dronc is the only CARD-domain containing in Drosophila and essential for apoptosis. Here, we report that homozygous dronc mutant adult animals are short-lived due to presence of a poorly developed, defective leaky intestine. Interestingly, this phenotype can be significantly rescued by enteroblast-specific expression + animals, suggesting proper function specifically enteroblasts, one four cell types intestine, critical normal development Furthermore, knockdown...
Adult stem cells maintain tissues by producing new and progeny that differentiate to replenish lost turnover or injury. Proper regulation of self-renewal, proliferation differentiation in cell lineages is crucial for tissue maintenance repair, preventing progression toward cancer. In many adult systems, the microenvironment which reside, niche, plays an important role maintaining a pool providing signals govern self renewal versus differentiation. The current paradigm from surrounding...
Abstract Drosophila Toll-1 and all mammalian Toll-like receptors regulate innate immunity. However, the functions of remaining eight Toll-related proteins in are not fully understood. Here, we show that Toll-9 is necessary sufficient for a special form compensatory proliferation after apoptotic cell loss (undead apoptosis-induced (AiP)). Mechanistically, AiP, interacts with to activate intracellular pathway nuclear translocation NF-κB-like transcription factor Dorsal which induces expression...
Summary The initiator caspase Dronc is the only CARD-domain containing in Drosophila and essential for apoptosis. Here, we report that homozygous dronc mutant adult animals are short-lived due to presence of a poorly developed, defective leaky intestine. Interestingly, this phenotype can be significantly rescued by enteroblast-specific expression + animals, suggesting proper Drone function specifically enteroblasts, one four cell types intestine, critical normal development Furthermore,...