A5112136346- Mitochondrial Function and Pathology
- Metabolism and Genetic Disorders
- Glycosylation and Glycoproteins Research
- Glycogen Storage Diseases and Myoclonus
- ATP Synthase and ATPases Research
- Pituitary Gland Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Genomics and Rare Diseases
- Cell Adhesion Molecules Research
- Urologic and reproductive health conditions
- Cancer, Hypoxia, and Metabolism
- Genetics and Neurodevelopmental Disorders
- Urinary Bladder and Prostate Research
- Galectins and Cancer Biology
- Bone and Dental Protein Studies
- Glioma Diagnosis and Treatment
- Algebraic and Geometric Analysis
- Blood transfusion and management
- Congenital heart defects research
- Cardiovascular and Diving-Related Complications
- Erythrocyte Function and Pathophysiology
- Cerebrovascular and Carotid Artery Diseases
- Peroxisome Proliferator-Activated Receptors
- Congenital gastrointestinal and neural anomalies
- Congenital limb and hand anomalies
Hospital Universitario Virgen del Rocío
1995-2013
Anthrologica
2001
The histochemical patterns of mucosubstances in 1.010 intestinal metaplasia (IM) foci stomachs removed during surgery for benign ulcer and carcinoma has been studied. Two kinds IM were characterized: the complete incomplete types, with first one subdivided Small intestine Type I, II, Colonic type, based on their similarity mucosubstances, those found normal small colon, second divided two groups, depending presence or absence sulfomucins. type sulfomucins was significantly more frequent...
Abstract Purpose: Tumors of the Ewing family are characterized by chromosomal translocations that yield chimeric transcription factors, such as EWS/FLI1, which regulate expression specific genes contribute to malignant phenotype. In present study, we show cholecystokinin (CCK) is a new target EWS/FLI1 oncoprotein and assess its functional role in tumor pathogenesis. Experimental Design: Relevant targets were identified using combination cell systems with inducible expression, tumors lines,...
Use of the PATS/KOH/PAS and PB/KOH/PAS techniques diamine method (Spicer 1965) together with demonstration metachromasia toluidine blue pH 3.0, for study carbohydrates in a retrospective gastric colorectal adenocarcinomas, disclosed an increase sulphate content absence O‐acylated sialomucins majority adenocarcinomas. In tumours there is no change degree sulphation normally present this area, but acylation sialic acid adenocarcinoma very different to that normal mucosa appears related...
Hirschsprung disease (HSCR, OMIM 142623) is a developmental disorder characterized by the absence of ganglion cells along variable lengths distal gastrointestinal tract, which results in tonic contraction aganglionic colon segment and functional intestinal obstruction. The RET proto-oncogene major gene associated to HSCR with differential contributions its rare common, coding noncoding mutations multifactorial nature this pathology. In addition, many other genes have been described be...
✓ An experimental model of kaolin-induced hydrocephalus in the dog was studied order to evaluate progress ventricular dilatation and communications between system subarachnoid space. Skull spine radiological studies were obtained after metrizamide intraventricular injection, baseline pressure cerebral pulse amplitude measured anesthetized animals. Intracranial compliance resistance drainage cerebrospinal fluid calculated by means bolus injection test. Light scanning electron microscope done...
The development of benign prostatic hyperplasia (BPH) is an androgen-dependent process which may be mediated by a number locally produced growth factors. One these, the basic fibroblast factor (bFGF or FGF2), has mitogenic effect on stroma. High expression levels bFGF have been reported in BPH. FGFR1 and FGFR2 receptors, that exhibit affinity for bFGF, identified normal hyperplastic prostate. Finasteride, 5alpha-reductase inhibitor, effective drug treatment BPH, inducing regressive changes...
Abstract Glial-derived neurotropic factor (GDNF) signaling is mediated through a 2-component system consisting of the so-called GDNF receptor-α (GFRα1), which binds to GDNF. This complex activates tyrosine kinase receptor RET. In this paper we demonstrate GDNF, GFRα1, and RET mRNA protein expression in human anterior pituitary gland. Double immunohistochemistry sections showed immunoreactivity more than 95% somatotrophs lesser extent corticotrophs (20%); it was almost absent remaining cell...
Abstract Abnormal carnitine distribution in muscle was found 22 of 77 patients (29%), with mitochondrial myopathy. Furthermore, total (TC) and free (FC) levels were lower than controls ( P < 0.01). Muscle long‐chain acylcarnitines (LCAC) significantly increased these deficiency 31.5% lipid storage myopathy (LSM) 25.6% ragged‐red fibers (RRF). Therefore, can be even the absence LSM. TC FC respiratory chain defects those normal In contrast, LCAC 0.05). Carnitine did not differ...
Prostatic atrophy has been documented histologically as a consequence of finasteride action on human hyperplastic prostates. An increase in apoptotic rates also reported androgen-deprived Transforming growth factor beta (TGF-beta) signaling is implicated cell death. TGF-betas have detected normal and diseased prostate. In the prostate, TGF-beta acts predominantly negative regulator. receptors TbetaRI TbetaRII shown to be negatively regulated by androgens.We studied histological changes 9...
Mucinous (colloid) adenocarcinomas secrete distinct O‐acylated forms of sialomucins: a histochemical study gastric, colorectal and breast Aims : represent group tumours defined by the presence large amounts extracellular mucins. By using methods, we analysed mucins secreted mucinous versus non‐mucinous looked for differential secretion profiles. Methods results Sixty‐four were studied (23 colorectal, 17 24 tumours). Thirty‐two colloid type. The following methods applied to paraffin tissue...
We found six patients with AMPD deficiency in muscle who were homozygous for the most common mutation, Q12X gene (AMPD1), associated this disease. Three had alone, showing a mild clinical phenotype. Two showed defect of PPL muscle, and mutation McArdle's disease, R49X (PYGM). In one these patients, phenotype was more severe than usually seen The remaining patient harbored mtDNA A3243G usual patterns mutation. conclude that AMPD1 may result effect; it is frequent Spanish population, therefore...
We studied two pedigrees with a mutation at the nucleotide 3243 of mitochondrial DNA (mtDNA). The proband from first pedigree had clinically defined MELAS plus maternally transmitted insulin-dependent diabetes mellitus (IDDM). propositus other exercise intolerance, lactic acidosis and ragged-red fibers (RRF). In pedigree, both mother sister's harbored point in their muscle. 40% mutant genomes sister 70%. second was present muscle blood as well all members studied. Proportion mtDNA 90% ranged...
Background The hallmark of HIV infection is the involution and destruction lymphoid tissue. However, very little information exists on effect highly active antiretroviral therapy (HAART) tissue structure. Objective To evaluate a HAART regimen after 48 weeks architecture cell regeneration tonsil in HIV-infected patients with CD4 T counts ≥ 500/μl. Methods From June 1997 to February 1998 all asymptomatic 500/μl seen at our unit were offered quadruple therapy. Tonsil biopsies obtained baseline...
Introduction: Cardiovascular diseases are the leading cause of death globally. 90% them derive from cardiovascular risk factors, modification which makes it possible to reverse their harmful consequences. Objective: Identify presence endothelial dysfunction in patients exposed classic factors.Method: An observational, descriptive study case series was carried out with a sample n=106 during period January 2022 2024, treated specialized cardiological prevention clinic, at Cardiology Center....