A5023949705- PARP inhibition in cancer therapy
- Toxin Mechanisms and Immunotoxins
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Calcium signaling and nucleotide metabolism
- Traumatic Brain Injury Research
- Pharmaceutical studies and practices
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Health and Medical Research Impacts
- Cardiac electrophysiology and arrhythmias
- Economic and Financial Impacts of Cancer
- Pediatric Hepatobiliary Diseases and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal and Anal Carcinomas
- RNA and protein synthesis mechanisms
- Neuroblastoma Research and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
Johns Hopkins University
2016-2020
MCPHS University
2018-2019
VA Boston Healthcare System
2016
ADP-ribosylation refers to the addition of one or more ADP-ribose units onto proteins post-translationally. This protein modification is often added by ADP-ribosyltransferases, commonly known as PARPs, but it can also be other enzymes, including sirtuins bacterial toxins. While past literature has utilized a variety methods identify ADP-ribosylated proteins, recent proteomics studies bring power mass spectrometry determine sites modification. To appreciate diverse roles across proteome, we...
Abstract ADP-ribosylation is a protein modification responsible for biological processes such as DNA repair, RNA regulation, cell cycle and biomolecular condensate formation. Dysregulation of implicated in cancer, neurodegeneration viral infection. We developed ADPriboDB (adpribodb.leunglab.org) to facilitate studies uncovering insights into the mechanisms significance ADP-ribosylation. 2.0 serves one-stop repository comprising 48 346 entries 9097 ADP-ribosylated proteins, which 6708 were...
Identification of alterations in ALK gene and development ALK-directed therapies have increased the need for accurate efficient detection methodologies. To date, research has focused on concordance between two most commonly used technologies, fluorescent situ hybridization (FISH) immunohistochemistry (IHC). However, inter-test reflects only one, albeit important, aspect diagnostic process; laboratories, hospitals, payors must understand cost workflow rearrangement strategies. Through...
ABSTRACT ADP-ribosylation refers to the addition of one or more ADP-ribose units onto proteins post-translationally. This protein modification is often added by ADP-ribosyltransferases, commonly known as PARPs, but it can also be other enzymes, including sirtuins bacterial toxins. While past literature has utilized a variety methods identify ADP-ribosylated proteins, recent proteomics studies bring power mass spectrometry determine sites modification. To appreciate diverse roles across...
ADP-ribosylation is a protein modification responsible for biological processes such as DNA repair, RNA regulation, cell cycle, and biomolecular condensate formation. Dysregulation of implicated in cancer, neurodegeneration, viral infection. We developed ADPriboDB (adpribodb.leunglab.org) to facilitate studies uncovering insights into the mechanisms significance ADP-ribosylation. 2.0 serves one-stop repository comprising 48,346 entries 9,097 ADP-ribosylated proteins, which 6,708 were newly...