A5064304774- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Gallbladder and Bile Duct Disorders
- Esophageal and GI Pathology
- Gastrointestinal disorders and treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Appendicitis Diagnosis and Management
- Gastric Cancer Management and Outcomes
- COVID-19 Clinical Research Studies
- Abdominal Surgery and Complications
- Colorectal Cancer Screening and Detection
- Biliary and Gastrointestinal Fistulas
- Long-Term Effects of COVID-19
- Gastrointestinal Tumor Research and Treatment
- Neuroblastoma Research and Treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Diverticular Disease and Complications
- Metastasis and carcinoma case studies
- Intestinal Malrotation and Obstruction Disorders
- Pneumothorax, Barotrauma, Emphysema
- Celiac Disease Research and Management
- Body Contouring and Surgery
Johns Hopkins University
2015-2025
Anne Arundel Medical Center
2024
Johns Hopkins Medicine
2013-2023
Dow University of Health Sciences
2023
Johns Hopkins Hospital
2014-2021
Walsh University
2017
Holy Family Red Crescent Medical College
2017
Asian Institute of Gastroenterology
2017
Southern Crescent Technical College
2017
Objectives: We evaluated factors associated with pathogenic genetic variants in patients idiopathic pancreatitis. Methods: Genetic testing (PRSS1, CFTR, SPINK1, andCTRC) was performed all eligible pancreatitis between 2010 to 2015. Patients were classified into the following groups based on a review of medical records: (1) acute recurrent (ARIP) or without underlying chronic pancreatitis; (2) (ICP) history ARP; (3) an unexplained first episode (AP)<35 years age; and (4) family Logistic...
Objective This study aimed to develop and validate a patient-reported outcome measure (PROM) in acute pancreatitis (AP) as an endpoint centred on the patient. Design A PROM instrument (PAtieNt-rePoRted OutcoMe scale pancreatItis, international proSpEctive cohort study, PAN-PROMISE scale) was designed based opinion of patients, professionals expert panel. The validated multicentre prospective describing severity AP quality life at 15 days after discharge main variables for validation. COSMIN...
OBJECTIVES: Cholecystectomy during or within 4 weeks of hospitalization for acute biliary pancreatitis is recommended by guidelines. We examined adherence to the guidelines incident mild-to-moderate and effectiveness cholecystectomy prevent recurrent episodes pancreatitis. METHODS: Individuals in 2010–2013 MarketScan Commercial Claims & Encounters database with a associated International Classification Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 577.0 574.x gallstone...
We have established a multicenter international consortium to better understand the natural history of acute pancreatitis (AP) worldwide and develop platform for future randomized clinical trials.The AP patient registry examine novel therapies in experience (APPRENTICE) was formed July 2014. Detailed web-based questionnaires were then developed prospectively capture information on demographics, etiology, history, comorbidities, risk factors, severity biomarkers, indices, health-care...
INTRODUCTION: Rectal indomethacin and topical spray of epinephrine have separately shown efficacy in the prevention post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) randomized controlled trials. We hypothesized that combination on duodenal papillae would further reduce PEP than when was used alone. Methods: conducted a comparative effectiveness, multicenter, double-blinded, trial rectal alone vs for high-risk patients. The primary outcome incidence secondary severity...
Abstract Background The prevalence and significance of digestive manifestations in COVID-19 remain uncertain. Methods Consecutive patients hospitalized with were identified across a geographically diverse alliance medical centers North America. Data pertaining to baseline characteristics, symptomatology, laboratory assessment, imaging, endoscopic findings from the time symptom onset until discharge or death manually abstracted electronic health records characterize prevalence, spectrum,...
Abstract Background Previous studies demonstrated limited accuracy of existing guidelines for predicting choledocholithiasis, leading to overutilization endoscopic retrograde cholangiopancreatography (ERCP). More accurate stratification may improve patient selection ERCP and allow use lower-risk modalities. Methods A machine learning model was developed using information from two published cohort that evaluated performance in choledocholithiasis. Prediction models were the gradient boosting...
Abstract Background and study aims Endoscopic ultrasound (EUS)-guided tissue sampling is the standard of care for diagnosing solid pancreatic lesions. While many two-way comparisons between needle types have been made in randomized controlled trials (RCTs), it unclear which size type offers best probability diagnosis. We therefore performed a network meta-analysis (NMA) to compare different sized shaped needles rank diagnostic performance each needle. Methods searched MEDLINE, EMBASE...
Opioids are commonly required for abdominal pain in hospitalized patients with acute pancreatitis (AP). The factors associated increased opioid requirements unknown.The medical records of adult inpatients AP from 2006 to 2016 were reviewed. Patients chronic pancreatitis, psychiatric comorbidities, intubation, opioid, and illicit drug use excluded. total quantity opioids during the first 7 days hospitalization was converted oral morphine equivalents (OME), divided by number obtain mean OME...
Objectives We compared outcomes of acute alcoholic pancreatitis (AAP), biliary (ABP), and post–endoscopic retrograde cholangiopancreatography (PEP). Methods This was a retrospective cohort study conducted at tertiary care center between June 2007 2012. Results A total 300 (68%) patients were diagnosed with AAP, 88 (20%) ABP, 55 (12%) PEP. Longer length hospital stay (LOHS) more common in ABP (23%) as AAP (10%) PEP (7%, P = 0.025). Pseudocyst ( 0.048), organ failure (OF) 0.01), need for...
Abstract Background and Aim The primary aim was to validate the Pancreatitis Activity Scoring System (PASS) in a multicenter prospectively ascertained acute pancreatitis (AP) cohort. Second, we investigated association of early PASS trajectories with disease severity length hospital stay (LOS). Methods Data were collected through APPRENTICE consortium (2015–2018). AP categorized based on revised Atlanta classification. Delta (ΔPASS) calculated by subtracting activity score from baseline...
INTRODUCTION: Recent pilot trials in acute pancreatitis (AP) found that lactated ringers (LR) usage may result decreased risk of moderately severe/severe AP compared with normal saline, but their small sample sizes limit statistical power. We investigated whether LR is associated improved outcomes an international multicenter prospective study. METHODS: Patients directly admitted the diagnosis were prospectively enrolled at 22 sites between 2015 and 2018. Demographics, fluid administration,...