A5100745757- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Pancreatic function and diabetes
- Periodontal Regeneration and Treatments
- Dental Implant Techniques and Outcomes
- Cell death mechanisms and regulation
- Advanced Breast Cancer Therapies
- Oral and gingival health research
- Pancreatic and Hepatic Oncology Research
Shanghai Ninth People's Hospital
2021
Shanghai Jiao Tong University
2021
Discovery Institute
2018
Sanford Burnham Prebys Medical Discovery Institute
2015-2018
University of California, San Diego
2015
Sun Yat-sen University
2011
Sun Yat-sen University Cancer Center
2011
Nanjing Normal University
2007
Pancreatic ductal adenocarcinoma (PDA) initiates from quiescent acinar cells that attain a Kras mutation, lose signaling basic helix-loop-helix (bHLH) transcription factors, undergo acinar-ductal metaplasia, and rapidly acquire increased growth potential. We queried whether PDA can be reprogrammed to revert their original cell state by shifting key programs.Human lines were engineered express an inducible form of the bHLH protein E47. Gene expression, growth, functional studies investigated...
Background: loss of the interdental papillae leads to formation a black triangle, which compromises smile esthetics and contributes food impaction plaque accumulation. The aim this study was evaluate efficacy injection hyaluronic acid (HA) compare it that physiological saline solution in restoration deficient gingival vivo vitro.Methods: Twenty-four patients with 68 were recruited for clinical trial split-mouth design. on one side anterior maxilla injected HA, those other solution. heights...
Background & AimsOncogenic mutations in KRAS, coupled with inactivation of p53, CDKN2A/p16INK4A, and SMAD4, drive progression pancreatic ductal adenocarcinoma (PDA). Overexpression MYC deregulation retinoblastoma (RB) further promote cell proliferation make identifying a means to therapeutically alter cell-cycle control pathways PDA significant challenge. We previously showed that the basic helix-loop-helix transcription factor E47 induced stable growth arrest cells vitro vivo. Here, we...