A5062568504- Natural Compound Pharmacology Studies
- Forensic Fingerprint Detection Methods
- Synthesis and biological activity
- Seaweed-derived Bioactive Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Chemical Synthesis and Analysis
- Essential Oils and Antimicrobial Activity
- Ferrocene Chemistry and Applications
- Ziziphus Jujuba Studies and Applications
- Synthesis of Organic Compounds
- Pain Mechanisms and Treatments
- Allelopathy and phytotoxic interactions
- Phytochemicals and Antioxidant Activities
- Protein Hydrolysis and Bioactive Peptides
- Morinda citrifolia extract uses
- Carbohydrate Chemistry and Synthesis
- Multicomponent Synthesis of Heterocycles
- Cholinesterase and Neurodegenerative Diseases
- Chemistry Education and Research
- Polysaccharides and Plant Cell Walls
- Olfactory and Sensory Function Studies
- Biological Stains and Phytochemicals
- Forensic Toxicology and Drug Analysis
- Studies on Chitinases and Chitosanases
- biodegradable polymer synthesis and properties
Universidade Federal de Santa Catarina
2013-2022
Universidade Federal de Pelotas
2009-2021
Cedrus atlantica essential oil (CaEO) presents analgesic and anti-inflammatory sedative properties. However, it remains unknown whether CaEO alleviates acute postoperative pain.Here, we investigated the effect of on pain its mechanisms related to descending control in Swiss males mice induced by a plantar incision surgery (PIS) hindpaw.Inhalation (5', 30' or 60') markedly reduced mechanical hypersensitivity. This was prevented pre-treatment with naloxone p-chlorophenylalanine methyl ester...
Natural products have long been used worldwide as therapeutic agents, but it is only recently, in response to the new challenges posed by global population aging, that interest research into potentially natural has reemerged. In this context, coumarins, chemical compounds found plants known anti-inflammatory activity, are promising candidates for development of drugs. study we test effect scopoletin, a coumarin several plant species, on carrageenan-induced inflammation mouse model pleurisy....
Isoflavones widely distributed in plants prevent diabetes. This study investigated the vivo and vitro effect of 3',4'-dihydroxy-6″,6″,6″',6″'-tetramethylbis(pyrano[2″,3″:5,6::2″',3″':7,8]isoflavone (bis-pyrano prenyl isoflavone) on glucose homeostasis hyperglycemic rats. The ethyl acetate fraction from aerial parts Polygala molluginifolia that contain isoflavones was assayed tolerance, maltase activity protein glycation. isoflavone bis-pyrano isolated this homeostasis. action exhibits an...
Despite substantial morbidity and mortality, no therapeutic agents exist for treatment of dengue or Zika, the currently available vaccine is only recommended virus (DENV)-immune individuals. Thus, development and/or preventive drugs urgently needed. DENV Zika (ZIKV) nonstructural protein 1 (NS1) can directly trigger endothelial barrier dysfunction induce inflammatory responses, contributing to vascular leak in vivo. Here we evaluated efficacy (1–6,1-3)-β-D-glucan isolated from Agaricus...
In this work we described the cultivation of Chlorella vulgaris in a photobioreactor to algal biomass production. The dried was used as feedstock for biodiesel production, it presented 26% lipids and via sonocatalysis stage methodology resulted 60% fatty acid methyl esters (FAME). FAME content confirmed by Gas Chromatography (GC).
Fingerprints are unique to each individual, contributing human identification in forensic cases.The powder technique being widely used is considered one of the most important latent fingermarks analysis.In this sense, present work aimed synthesize 1-thiocarbamoyl-4,5dihydro-1H-pyrazoles and apply them as agents develop fingermarks.The compounds were prepared from an effective green synthesis via condensation chalcones with thiosemicarbazide ethanol under microwave irradiation.Pyrazoles...
In this study crude extracts from 10 species among of the 39 Polygala L. genus found in South region Brazil, were subjected to screening for antitumor activity against tumor cell lines, HL-60 (myeloid leukemia), Jurkat (lymphoblastic THP-1 (monocytic MCF-7 and MDA-MB-231 (breast carcinoma), HCT-116 (colorectal carcinoma) Vero (kidney green monkey, used as a non -tumor model).The evaluation was carried out using MTT assay.Only densiracemosa, campestris molluginifolia inhibited viability by...
Context: Polygala sabulosa, popularly known as “timutu-pinheirinho,” has been used in Brazilian folk medicine for the treatment of bowel and kidney disorders an expectorant. Objective: Evaluate anti-inflammatory effects crude extract (CE), acetonic fraction (Ac), main compound, 7-prenyloxi-6-methoxycoumarin (PC) on a mouse model carrageenan-induced pleurisy. Materials Methods: A pleurisy was to investigate P. sabulosa CE, Ac PC leukocyte migration, exudate formation, activities...
SYNTHESIS OF BIOACTIVE HETEROCYCLIC FERROCENE DERIVATIVES.The discovery of ferrocene marked one the points departure for modern organometallic chemistry.In general, compounds derivatives are widely applied in several areas.One most important applications is development more active drugs, especially cases where there resistance to current drugs.Bioactive agents containing have proven effective combating diseases such as cancer, malaria, HIV, Alzheimer and conditions caused by fungi...
Uma investigação fitoquímica de Polygala molluginifolia (raiz, caule, folhas e flores) resultou no isolamento quatro piranoisoflavonas das quais a isoflavona 1 é desconhecida na literatura.As isoflavonas 2-4, embora sejam compostos sintéticos conhecidos são descritos neste trabalho como novos produtos naturais.Os isolados foram avaliados em termos do seu efeito antioxidante o potencial para inibir enzima acetilcolinesterase.As 4 inibiram acetilcolinesterase, exibindo valores IC 50 68 µmol L...
The development of fingermarks is an important step in criminal cases.Latent require applications reagents to be developed before they can visualized.Different techniques enhance fingermarks' visualization have been employed and the powder dusting most common among them.The use food spices as latent developers could alternative method experiment chemistry teaching, considering that are low cost accessible.In this work, experimental methodology was applied undergraduate teaching for...
Oxadiazoles are heterocyclic compounds with a variety application in many pharmaceuticals and agrochemicals products.We reported here the convenient synthesis of 3-trichloromethyl-1,2,4oxadiazoles from trichoroacetoamidoxime RC(O)Cl (R= methyl ethyl, propyl, Ph, CH 2 Cl, CHCl , CCl 3 ) by one pot reaction.