A5016266153- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Vibrio bacteria research studies
- Estrogen and related hormone effects
- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Peptidase Inhibition and Analysis
- Cancer-related Molecular Pathways
- Bacteriophages and microbial interactions
- Hemoglobinopathies and Related Disorders
- Urinary and Genital Oncology Studies
- Neurological and metabolic disorders
- Histone Deacetylase Inhibitors Research
- Bladder and Urothelial Cancer Treatments
- Pharmacological Effects and Toxicity Studies
- Genomics and Chromatin Dynamics
- Lung Cancer Treatments and Mutations
Levine Cancer Institute
2020-2022
The University of Texas at Austin
2015-2018
University College Cork
2009-2010
Since persister cells cause chronic infections and since Escherichia coli toxin MqsR increases persisters, we used protein engineering to increase the toxicity of gain insights into cell formation. Through two amino acid replacements that increased stability MqsR, persistence were increased. A whole-transcriptome study revealed variant by repressing genes for resistance, multidrug resistance osmotic resistance. Corroborating these microarray results, deletion rpoS, as well master stress...
Biomarkers are needed in muscle-invasive bladder cancer (MIBC). We previously reported that high tumor aurora kinase (AURK) A expression identifies patients with MIBC poor prognosis. Aberrant p53 has also been associated outcomes MIBC, though to the best of our knowledge, co-expression rates and kinases have not described MIBC. As family members may co-regulate each other, present study investigated whether or p63 protein influenced prognostic value AURKA a pilot 50 treated curative intent....
Spontaneous nfxC-type phenotypic mutants of Pseudomonas aeruginosa are characterized by chloramphenicol resistance and increased expression the multidrug efflux pump, MexEF-OprN. These frequently arise during propagation bacteria in laboratory conditions. This study shows that some discrepancies transcriptomic/phenotypic profiles two rsmA mutants, PAZH13 (rsmA mutant strain PAO1) PAKΔrsmA, due to nature PAZH13. indicates awareness possible occurrence these spontaneous phenotypes is...
Abstract Purpose: Estrogen receptor 1 ( ESR1 ) mutations and fusions typically arise in patients with hormone receptor-positive breast cancer after aromatase inhibitor therapy, whereby is constitutively activated a ligand-independent manner. These variants can impact treatment response. Herein, we characterize among molecularly profiled cancers. Methods: DNA next-generation sequencing (592-gene panel) data from 9860 samples were retrospectively reviewed. Gene detected using the ArcherDx...