A5102823323- Tuberculosis Research and Epidemiology
- Acne and Rosacea Treatments and Effects
- Mycobacterium research and diagnosis
- Dermatology and Skin Diseases
- Diagnosis and treatment of tuberculosis
- melanin and skin pigmentation
- Pneumonia and Respiratory Infections
- Skin Protection and Aging
- COVID-19 Clinical Research Studies
- Antimicrobial Peptides and Activities
- COVID-19 and Mental Health
- Pneumocystis jirovecii pneumonia detection and treatment
- Cutaneous Melanoma Detection and Management
- Pharmacological Effects of Natural Compounds
- Cytokine Signaling Pathways and Interactions
- SARS-CoV-2 and COVID-19 Research
- Microbial Inactivation Methods
- Skin and Cellular Biology Research
- Vasculitis and related conditions
- Wound Healing and Treatments
- Diverse Scientific Research Studies
- Neonatal and Maternal Infections
- Sepsis Diagnosis and Treatment
- Bone Metabolism and Diseases
- Silk-based biomaterials and applications
National University of Medical Sciences
2019-2024
Queen Mary University of London
2020-2024
The Women University Multan
2024
COMSATS University Islamabad
2024
King Saud University
2024
Stanford University
2024
NYU Langone Health
2015-2021
Quaid-i-Azam University
2014-2021
Sadick Dermatology
2015
BackgroundHaematopoietic stem cells expressing the CD34 surface marker have been posited as a niche for Mycobacterium tuberculosis complex bacilli during latent infection. Our aim was to determine whether M DNA is detectable in CD34-positive peripheral blood mononuclear (PBMCs) isolated from asymptomatic adults living setting with high burden.MethodsWe did cross-sectional study Ethiopia between Nov 22, 2017, and Jan 10, 2019. Digital PCR (dPCR) used PBMCs 100 mL taken HIV infection or...
The cytokine tumour necrosis factor (TNF)‐α is a well‐studied potent candidate mediator that systemically involved in variety of inflammatory diseases. Several single nucleotide polymorphisms (SNPs) the TNF‐α gene have been studied with regard pathogenesis acne vulgaris, but results inconclusive. This case–control study investigated association TNF ‐308 G>A and ‐238 SNPs vulgaris high‐risk Pakistani population. In total, 160 healthy controls 140 patients were enrolled this study....
Abstract Background Pakistan ranks amongst the top 20 highest burden tuberculosis (TB) countries in world. Approximately 369,548 cases of TB (all forms) were notified 2018, with an estimated incidence 265 per 100,000 people year. In other settings, has been shown to demonstrate seasonal variation, higher spring/summer months and lower autumn/winter; amplitude variation also reported be increasing distance from equator. Methods Notifications newly-diagnosed pulmonary extrapulmonary obtained...
Acne is an inflammatory condition principally affected by genetic and dietary factors. Investigation into functional polymorphisms of TNF-α gene their association with acne vulgaris will be helpful in exploring influence on skin immune mediated events. In the present study, we analyzed polymorphisms, its expression levels lipid profiles a large cohort patients controls. We used PCR-RFLP to study at −857C/T, −863C/A −1031 T/C sites vulgaris. Lipid were measured using enzymatic end-point...
Sepsis is the most common cause of neonatal mortality and responsible for 30-50% total deaths each year in developing countries. The objective study was to determine diagnostic accuracy Creactive protein (CRP) sepsis. Fifty nine consecutive patients with risk factors clinical features suggestive CRP sepsis were selected as per operational definition fulfilling inclusion exclusion criteria. Detailed physical examination carried out. Blood sample culture taken from all patients. Results blood...
Abstract Both vitamin D deficiency and single nucleotide polymorphisms (SNPs) in the gene encoding receptor (VDR) have been widely reported to associate with susceptibility polycystic ovarian syndrome (PCOS). A case-control study was conducted influence of status genotpye for 24 SNPs four genes pathway (VDR, DBP, CYP27B1, CYP24A1) on PCOS. Statistical analyses were identify phenotypic genotypic factors associated risk PCOS test interactions between genotype status. independently lower age,...
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Iron deficiency anemia (IDA) is the highest nutritional worldwide. It a multifactorial disease, with higher morbidity rate. TMPRSS6 polymorphisms importantly rs855791 found to play an essential role in iron homeostasis human body. The (T > C) polymorphism highly associated levels, and multiple blood parameters, leading IDA. of significance complete count (CBC) parameters pathogenesis IDA not yet studied Pakistani population.
Osteoporosis and diabetes mellitus (DM) are widespread diseases have a significant health burden. Type-1 (T1DM) Type-2 (T2DM) associated with an increased bone fracture. In T1DM, the risk of fracture is low mass. patients T2DM, due to quality bone, despite mineral density (BMD). type 2 diabetic patients, fragility depends on instead reduction in Thiazolidinediones (TZD) cause differentiation adipocytes inhibit osteoblast marrow stromal stem cells (BMSC). this review, we described effect...
Abstract With the onset of coronavirus disease in December 2019, normal routine and lifestyle humans has adversely affected all over world. This change not only increased level stress anxiety, but also badly modified eating habits during lockdown period. rate binge disorder people who were already immune-compromised. rapid communication aims to develop awareness among stay calm this pandemic eat healthy.
Tuberculosis (TB) remains a significant global health concern, particularly in low- and middle-income countries. Several risk factors are associated with TB infection its progression from to disease onset, including host factors, microbial environmental socio-economic status. Host genetic play role determining susceptibility acquiring infection, active disease, the severity of disease. Innate immunity is essential initial defense, advancement, long-term control mycobacterial infection. Among...
Abstract Host genetics is pivotal in deciding disease susceptibility and outcome individuals infected with Mycobacterium tuberculosis (Mtb). Scavenger receptors are PRRs that play a vital role facilitating molecular interactions between Mtb the host. This interaction can potentially be modified by polymorphisms scavenger receptor genes. The of TB or LTBI pathogenesis has not yet been studied. Therefore, we designed case-control study to investigate association CD36 gene at rs1761667 (G>A)...
<h3>Background:</h3> Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare and severe autoimmune disease, characterized by pauci-immune necrotizing leading to inflammation damage of major organs. In AAV, autoantibodies against neutrophil antigens, including proteinase-3 (PR3) or myeloperoxidase (MPO), the ANCA producing B cells play central role in pathogenesis. Autoreactive T their features are less well-studied, but recent studies suggest importance pathogenesis...
ABSTRACT Background We have previously reported detection of genomic DNA Mycobacterium tuberculosis (Mtb) in peripheral blood mononuclear cells (PBMC) asymptomatic adults with recent household exposure to an index case infectious pulmonary (TB). It is not known whether this phenomenon indicates quiescent Mtb infection or incipient TB disease. Methods did a cross-sectional study nested prospective component, utilizing samples collected from studied cohort contacts recruited Ethiopia detect...