A5064767379- Marine Invertebrate Physiology and Ecology
- Genetic diversity and population structure
- Genomics and Phylogenetic Studies
- Marine Ecology and Invasive Species
- Protist diversity and phylogeny
- Marine and fisheries research
- Coral and Marine Ecosystems Studies
- Physiological and biochemical adaptations
- Parasite Biology and Host Interactions
- Yersinia bacterium, plague, ectoparasites research
- Marine Biology and Ecology Research
- Machine Learning in Bioinformatics
- Evolution and Paleontology Studies
- Crustacean biology and ecology
- Zebrafish Biomedical Research Applications
- Genomics, phytochemicals, and oxidative stress
- NF-κB Signaling Pathways
- Sperm and Testicular Function
- Protein Kinase Regulation and GTPase Signaling
- Hippo pathway signaling and YAP/TAZ
- Cephalopods and Marine Biology
- Cell death mechanisms and regulation
- Gene expression and cancer classification
- Cancer-related Molecular Pathways
- Genetics, Bioinformatics, and Biomedical Research
Sorbonne Université
2020-2024
Centre National de la Recherche Scientifique
2020-2023
Laboratoire de Biologie du Développement de Villefranche-sur-Mer
2020-2023
Collège de France
2019-2023
Centre Interdisciplinaire de Recherche en Biologie
2019-2023
Inserm
2020-2023
Université Paris Sciences et Lettres
2020-2023
Brown University
2016-2022
National Oceanography Centre
2015-2018
University of Southampton
2015-2018
Article10 February 2016Open Access Transparent process miR-515-5p controls cancer cell migration through MARK4 regulation Olivier E Pardo Corresponding Author Department of Surgery & Cancer, Division Imperial Centre for Translational and Experimental Medicine (ICTEM), College, Hammersmith Hospital Campus, London, UK Search more papers by this author Leandro Castellano Catriona Munro Yili Hu Oncology, College Healthcare NHS Trust, Charing Cross Hospital, Francesco Mauri Jonathan Krell Romain...
Significance Comparisons of genome function between species are providing important insight into the evolutionary origins diversity. Here, we show that comparative functional genomics studies can come to wrong conclusions if they do not take relationships account and instead rely on pairwise comparisons species, as is common practice. We reexamined two previously published found problems with draw both their original question. One study support for ortholog conjecture, other concluded...
The Portuguese man of war, Physalia physalis, is one the most conspicuous, but poorly understood members pleuston, a community organisms that occupy habitat at sea-air interface. physalis siphonophore uses gas-filled float as sail to catch wind. development, morphology, and colony organization P. very different from all other siphonophores. Here, we look live fixed larval juvenile specimens, use optical projection tomography build on existing knowledge about morphology development this...
Siphonophores are complex colonial animals, consisting of asexually produced bodies (zooids) that functionally specialized for specific tasks, including feeding, swimming, and sexual reproduction. Though this extreme functional specialization has captivated biologists generations, its genomic underpinnings remain unknown. We use RNA-seq to investigate gene expression patterns in five zooids one tissue across seven siphonophore species. Analyses species present several challenges,...
During meiosis, DNA recombination allows the shuffling of genetic information between maternal and paternal chromosomes. Recombination is initiated by double-strand breaks (DSBs) catalyzed conserved enzyme Spo11. How this crucial event connected to other meiotic processes unexpectedly variable depending on species. Here, we knocked down Spo11 CRISPR in jellyfish Clytia hemisphaerica. Germ cells mutants fail assemble synaptonemal complexes chiasmata, consequence, homologous chromosome pairs...
Siphonophores are a diverse group of hydrozoans (Cnidaria) that found at most depths the ocean - from surface, like familiar Portuguese man war, to deep sea. They play important roles in ecosystems, and among abundant gelatinous predators. A previous phylogenetic study based on two ribosomal RNA genes provided insight into internal relationships between major siphonophore groups. There was, however, little support for many within clade Codonophora. Here, we present new phylogeny...
Abstract Death-associated protein kinase (DAPK) 2 is a serine/threonine that belongs to the DAPK family. Although it shows significant structural differences from DAPK1, founding member of this family, DAPK2 also thought be putative tumour suppressor. Like has been implicated in programmed cell death, regulation autophagy and diverse developmental processes. In contrast however, few mechanistic studies have carried out on majority these made use tagged DAPK2, which almost invariably leads...
In the last decade, genomics has come to play a central role in systematics and biodiversity research. coming years, phylogenetics will an increasingly important genomics. Here, we address false dichotomy between descriptive‐ hypothesis‐driven work, discuss power of descriptive test questions broad interest explore applications challenges that arise as comparative genomic analyses include more species. Integrated phylogenetic genome sequences organism phenotypes across many species provide...
Extant deep-sea invertebrate fauna represent both ancient and recent invasions from shallow-water habitats. Hydrostatic pressure may present a significant physiological challenge to organisms seeking colonize deeper waters or migrate ontogenetically. Pressure be key factor contributing bottlenecks in the radiation of taxa potentially drive speciation. Here, we assess shifts tolerance hydrostatic through early ontogeny northern stone crab Lithodes maja , which occupies depth range 4–790 m...
With detailed data on gene expression accessible from an increasingly broad array of species, we can test the extent to which our developmental genetic knowledge model organisms predicts patterns and variation across species. But know when differences in species are significant, first need how much evolutionary expect observe. Here provide answer by analyzing RNAseq twelve Hawaiian Drosophilidae flies, focusing between ovary other tissues. We show that over time, there exists a cohort...
Abstract There is considerable interest in comparing functional genomic data across species. One goal of such work to provide an integrated understanding genome and phenotype evolution. Most comparative studies have relied on multiple pairwise comparisons between species, approach that does not incorporate information about the evolutionary relationships among The statistical problems arise from considering these can lead approaches wrong conclusions, are a missed opportunity learn biology...
Abstract The Portuguese man of war, Physalia physalis , is a siphonophore that uses gas-filled float as sail to catch the wind. It one most conspicuous, but poorly understood members pleuston, community organisms occupy habitat at sea-air interface. development, morphology, and colony organization P. very different from all other siphonophores. Here, we propose framework for homologizing axes with siphonophores, also suggest tentacle bearing zooids should be called tentacular palpons. We...
Abstract Background Siphonophores are complex colonial animals, consisting of asexually-produced bodies (called zooids) that functionally specialized for specific tasks, including feeding, swimming, and sexual reproduction. Though this extreme functional specialization has captivated biologists generations, its genomic underpinnings remain unknown. We use RNA-seq to investigate gene expression patterns in five zooids one tissue (pneumatophore) across seven siphonophore species. Analyses...
Abstract Siphonophores are a diverse group of hydrozoans (Cnidaria) that found at all depths the ocean - from surface, like familiar Portuguese man war, to deep sea. play an important role in ecosystems, and among most abundant gelatinous predators. A previous phylogenetic study based on two ribosomal RNA genes provided insight into internal relationships between major siphonophore groups, however there was little support for many within clade Codonophora. Here, we present new phylogeny...
Abstract The open ocean is a vast, highly connected environment, and the organisms found there have been hypothesized to represent massive, well-mixed populations. Of these, Portuguese man-o’-war ( Physalia ) uniquely suited dispersal, sailing surface with muscular crest. We tested hypothesis of single, panmictic population by sequencing 133 genomes, five distinct lineages, multiple lines evidence showing strong reproductive isolation despite range overlap. then scored thousands...
Abstract Evolutionary transitions between individual and colonial organisms remain enigmatic. Siphonophores, abundant pelagic cnidarians, exhibit a complex colony structure composed of repeated (zooid) clusters called cormidia. Many siphonophores release their posterior-most cormidia as independent fragments known eudoxids, ensuring sexual reproduction. However, the mechanisms eudoxid production its evolutionary origins are unknown. Using live imaging, immunohistochemistry pharmacological...
1 Abstract With detailed data on gene expression accessible from an increasingly broad array of species, we can test the extent to which our developmental genetic knowledge model organisms predicts patterns and variation across species. But know when differences in species are significant, first need how much evolutionary expect observe. Here provide answer by analyzing RNAseq twelve Hawaiian Drosophilidae flies, focusing between ovary other tissues. We show that over time, there exists a...