A5067671014- Cytokine Signaling Pathways and Interactions
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- HER2/EGFR in Cancer Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Invertebrate Immune Response Mechanisms
- Melanoma and MAPK Pathways
- RNA Research and Splicing
- BRCA gene mutations in cancer
- Cancer-related Molecular Pathways
- Insect symbiosis and bacterial influences
- Cell death mechanisms and regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Medicinal plant effects and applications
- Rabbits: Nutrition, Reproduction, Health
- Global Cancer Incidence and Screening
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- Cancer Treatment and Pharmacology
- NF-κB Signaling Pathways
- Kruppel-like factors research
- Quinazolinone synthesis and applications
- Behavioral Health and Interventions
ISPA - Instituto Universitário
2022
Instituto Gulbenkian de Ciência
2015
Imperial College London
2008-2014
Hammersmith Hospital
2008-2013
Centro de Investigação em Biodiversidade e Recursos Genéticos
2008-2009
Instituto Nacional de Investigação Agrária e Veterinária
2008-2009
Universidade do Porto
2006
Symbiotic interactions between microbes and their multicellular hosts have manifold impacts on molecular, cellular organismal biology. To identify candidate bacterial genes involved in maintaining endosymbiotic associations with insect hosts, we analyzed genome-wide patterns of gene expression the alpha-proteobacteria Wolbachia pipientis across life cycle Drosophila melanogaster using public data from modENCODE project that was generated a Wolbachia-infected version ISO1 reference strain. We...
The development of resistance to chemotherapy is a major cause cancer-related death. Elucidating the mechanisms drug should thus lead novel therapeutic strategies. Fibroblast growth factor (FGF)-2 signaling induces assembly multi-protein complex that provides tumor cells with molecular machinery necessary for resistance. This complex, which involves protein kinase C (PKC) ε, v-raf murine sarcoma viral oncogene homolog B1 (B-RAF) and p70 S6 β (S6K2), enhances selective translation...
Janus kinases (JAKs) and signal transducers activators of transcription (STATs) are essential for responses to interferons (IFNs), most cytokines, some growth factors. JAK/STAT signaling is not, however, sufficient a full IFN-gamma response. Here, convenient, robust, quantitative flow cytometry-based kinome-wide siRNA screen has identified nine additional as required the class II HLA response, seven an antiviral two cytopathic response encephalomyocarditis virus (EMCV). As one example,...
Summary Chemokines receptors are transmembrane proteins that bind chemokines. and their known to play a crucial role in the immune system pathogen entry. There is evidence myxoma virus, causative agent of myxomatosis, can use chemokine receptor CXCR4 infect cells. This virus causes benign disease its natural host, Sylvilagus , but European rabbit ( Oryctolagus cuniculus ) it highly fatal infectious as myxomatosis. We have characterized gene five genera order Lagomorpha, Ochotona...
Summary Unlike other species, European rabbit ( Oryctolagus cuniculus ) possesses only one immunoglobulin gamma class. Allelic diversity at the Ig (immunoglobulin) constant region encoded by unique IGHG (immunoglobulin heavy gamma) gene is moreover much reduced. In rabbit, genetic variation IGGH hinge limited to a single nucleotide substitution, which causes Met–Thr interchange amino acid position 9 (IMGT numbering). We have analysed this more in‐depth by, (1) analysing allelic in 11 breeds...
(1) Background: Breast cancer (BC) shows significant epidemiological differences between Eastern and Western countries. These may arise from socio-cultural factors influencing how healthy young women perceive this condition, their risk of getting cancer, the implications for preventive screening behaviors. In study, illness perceptions, individual perception, compared risk, beliefs about behaviors BC female university students were using an anonymous online survey a European country...