A5074006991- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Pregnancy and preeclampsia studies
- Estrogen and related hormone effects
- Uterine Myomas and Treatments
- Preterm Birth and Chorioamnionitis
- Reproductive Biology and Fertility
- Pregnancy-related medical research
- Birth, Development, and Health
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Angiogenesis and VEGF in Cancer
- Prenatal Screening and Diagnostics
- Maternal and fetal healthcare
- Cytokine Signaling Pathways and Interactions
- Neonatal Respiratory Health Research
- Endoplasmic Reticulum Stress and Disease
- Assisted Reproductive Technology and Twin Pregnancy
- Congenital heart defects research
- Endometrial and Cervical Cancer Treatments
- Ovarian function and disorders
- MicroRNA in disease regulation
- Atherosclerosis and Cardiovascular Diseases
- Intestinal and Peritoneal Adhesions
- Pregnancy and Medication Impact
- Chemokine receptors and signaling
University of South Florida
2016-2025
The Ohio State University
2012-2014
Yale University
2004-2013
Bipar
2013
Dokuz Eylül University
2011
Istanbul University
2006-2011
University of Oxford
2011
Istanbul University-Cerrahpaşa
2010
Chang Gung University
2006-2007
University of Ulsan
2006-2007
Abstract The first known hormonal signal of the conceptus during implantation is human chorionic gonadotropin (hCG). Interestingly, increased apoptosis in endometrium coincides with window. Factors from fetal or placental origin as well maternal factors are likely to have a potential role regulation apoptotic signaling molecules. We hypothesized that hCG may be link for development local immunotolerance. Fas-Fas ligand (FasL) system one pathways, shown important immune tolerance and after...
Extravillous trophoblasts (EVTs) invade human decidua via sequential integrin-mediated binding and proteolysis of basement membrane proteins in the extracellular matrix (ECM). In preeclampsia, shallow EVT invasion impairs spiral artery arteriole remodeling to reduce uteroplacental blood flow. Excess decidual cell-expressed metalloproteinases (MMPs) 2 9, response preeclampsia-related interleukin 1 beta (IL1B) tumor necrosis factor alpha (TNF), may inappropriately degrade these impede...
Preeclampsia (PE) is a common cause of maternal morbidity, characterized by impaired trophoblast invasion and spiral artery transformation resulting in progressive uteroplacental hypoxia. Given the primary role LIN28A LIN28B modulating cell metabolism, differentiation, invasion, we hypothesized that and/or regulates differentiation its dysregulation may contribute to PE. Here show expressed ∼1300-fold higher than human term placenta predominant paralog cultures. The expression mRNA protein...
Estrogen-bound estrogen receptors (ER) alpha and beta classically activate gene expression after binding to the response element in promoter regions of target genes. Estrogen also has rapid, nongenomic effects. It activates several membranous or cytoplasmic kinase cascades, including phosphatidylinositol 3-phosphate (PI3K/Akt) cascade, a signaling pathway that plays key role cell survival apoptosis. Normal human endometrium is exposed variable levels steroid hormones throughout menstrual...
First trimester human decidua is composed of decidual cells, CD56brightCD16− natural killer (dNK) and macrophages. Decidual cells incubated with NK cell–derived IFN-γ either macrophage-derived TNF-α or IL-1β synergistically enhanced mRNA protein expression IP-10 I-TAC. Both chemokines recruit CXCR3-expressing cells. This synergy required receptor 1 2 mediation via JAK/STAT NFκB signaling pathways. However, was not observed on neutrophil, monocyte, cell–recruiting chemokines. Immunostaining...
BACKGROUNDHuman female meiosis is particularly error prone, leading to the generation of aneuploidy, a problem which increases dramatically with advancing age. Despite being great clinical importance, genesis oocyte aneuploidy remains poorly understood. Cumulus cells (CCs) surround oocytes in antral follicles and play crucial role regulating their maturation. During this investigation, we aimed obtain an insight into follicular environment that become aneuploid identify non-invasive markers...
During implantation, cytotrophoblasts undergo epithelial-to-mesenchymal transition (EMT) as they differentiate into invasive extravillous trophoblasts (EVTs). The primate-specific microRNA cluster on chromosome 19 (C19MC) is exclusively expressed in the placenta, embryonic stem cells and certain cancers however, its role EMT gene regulation unknown. In situ hybridization for miR-517a/c, a C19MC cistron microRNA, first trimester human placentas displayed strong expression villous gradual...
Abstract As the space industry grows exponentially and aspirations for travel expand, we are entering a new era where will very likely become an interplanetary species. Although reproduction is essential human function necessary species survival, have remarkably little knowledge regarding impact of on female reproductive system. The effects spaceflight potential, fertility, implantation subsequent pregnancy resulting in healthy live birth must be considered before planning prolonged missions...
PTEN (phosphatase and tensin homolog deleted on chromosome 10) is a tumor suppressor gene, mutated frequently in variety of human tumors. regulates cell growth, apoptosis, proliferation. Phosphorylation tail causes its inactivation decreases degradation. There little known about the regulation by ovarian steroids. We hypothesized that expression endometrium variable throughout menstrual cycle early pregnancy, steroids regulate because critical many steroid-sensitive tissues such as...
Implantation involves a complex set of events, including apoptosis in endometrial cells. Apoptosis human endometrium coincides with the implantation window, suggesting potential role for steroid hormones its regulation. Fas ligand (FasL) is one mediators differentiated cells and embryonic development. Interaction FasL receptor, Fas, induces through autocrine paracrine signaling. We hypothesized that expression cycle-dependent sex regulate expression. first studied menstrual by...
Blood vessel growth and regression in human endometrium are regulated throughout the menstrual cycle. We sought a direct role of ovarian steroids on endometrial endothelial cell (HEEC) proliferation vascularization. To investigate HEEC angiogenicity sex steroids, we developed reliable method for isolation HEEC, which allowed us to angiogenic effects using immunohistochemistry, immunocytochemistry, Western blot,...
Endometrium consists of different cell populations such as epithelial and stromal cells is mainly regulated by sex steroids. Isoflavones are plant-derived estrogenic compounds that have antiestrogenic properties in a cell-specific manner. We hypothesized one the potential health benefits isoflavones may be their ability to regulate endometrial function. The present study was conducted assess and/or effects (genistein, genistin, daidzein, daidzin) cultured human glandular (Ishikawa) MTT...