A5048994129- Insect Resistance and Genetics
- Mosquito-borne diseases and control
- Insect Pest Control Strategies
- Insect and Arachnid Ecology and Behavior
- Malaria Research and Control
- Neurobiology and Insect Physiology Research
- Insect-Plant Interactions and Control
- Insect behavior and control techniques
- Insect and Pesticide Research
- Physiological and biochemical adaptations
- Hymenoptera taxonomy and phylogeny
- Animal Behavior and Reproduction
- Plant and animal studies
- Hemoglobinopathies and Related Disorders
- Entomological Studies and Ecology
- Iron Metabolism and Disorders
- Arsenic contamination and mitigation
- Forest Insect Ecology and Management
- Cervical Cancer and HPV Research
- Heavy Metal Exposure and Toxicity
- Reproductive tract infections research
- Hepatitis B Virus Studies
- Agricultural pest management studies
- Viral Infections and Vectors
- Insects and Parasite Interactions
Boston Children's Hospital
2022-2025
Indian Institute of Toxicology Research
2019-2025
Indira Gandhi Medical College
2013-2024
Vanderbilt University Medical Center
2023-2024
Harvard University
2022-2024
Manav Rachna International Institute of Research and Studies
2023-2024
Gandhi Medical College & Hospital
2023-2024
University of Delhi
1975-2024
Jamia Hamdard
2024
Department of Biotechnology
2024
Background & Aims: Oral linaclotide, a novel agonist of guanylate cylase-C, stimulates intestinal fluid secretion and transit, decreases visceral hypersensitivity in animal studies. In healthy volunteers, linaclotide was safe, well tolerated, increased stool frequency, decreased consistency time to first bowel movement. This randomized, double-blind, placebo-controlled study evaluated the effects oral 100 1000 μg once daily, 36 women with constipation-predominant irritable syndrome; colonic...
Abstract Although amplifications and mutations in receptor tyrosine kinases (RTKs) act as bona fide oncogenes, most cancers, RTKs maintain moderate expression remain wild-type. Consequently, cognate ligands control many facets of tumorigenesis, including resistance to anti-RTK therapies. Herein, we show that the for MET RON, HGF HGFL, respectively, are synthesized inactive precursors activated by cellular proteases. Our newly generated HGF/HGFL protease inhibitors could overcome both de novo...
Plasma microRNAs (miRNAs) have recently garnered attention for their potential as stable biomarkers in the context of Prostate Cancer (PCa), demonstrating established associations with tumor grade, biochemical recurrence (BCR), and metastasis. This study seeks to assess utility plasma miRNAs prognostic indicators distinguishing between high-grade low-grade PCa, explore involvement PCa pathogenesis.
ABSTRACT The mesoscale organization of cells is central to cellular physiology and pathology. Cellular condensates often form via biomolecular phase separation, mediated by intrinsically disordered regions (IDRs) represent a key mechanism for organization. TRI-partite Motif (TRIM) family ubiquitin ligases implicated in diverse functions disease, yet the role condensation TRIM remains understudied. Here, we systematically investigate localization 72 proteins, revealing that majority distinct...
AbstractWe investigated within as well between population variability in desiccation resistance, cuticular lipid mass per fly and water loss nine geographical populations of a tropical drosophilid, Zaprionus indianus. Interestingly, the amount lipids resistance this non-melanic species are significantly higher compared with melanic Drosophila melanogaster. On basis isofemale line analysis, trait is positively correlated negatively but show lack correlation body size. We observed variation...
A strain of Culex quinquefasciutus with European cytoplasm and Indian chromosomes, including a male‐linked translocation, was reared males were released in two villages near Delhi which surrounded by 3‐km wide zone kept free mosquito production conventional larvicides. 5000‐40,000 per day village this produced very high ratios to wild males. As result matings females up 68% the egg rafts laid showed cytoplasmic incompatibility (sterility) but, despite continued releases, sterility rate...
Journal Article Anopheles stephensi: Effect of Gamma-Radiation and Chemosterilants on the Fertility Fitness Males for Sterile Male Releases Get access V. P. Sharma, Sharma Malaria Research Centre (ICMR), 22 Sham Nath Marg, Delhi—110054, India Search other works by this author on: Oxford Academic PubMed Google Scholar R. K. Razdan, Razdan M. A. Ansari Economic Entomology, Volume 71, Issue 3, 1 June 1978, Pages 449–452, https://doi.org/10.1093/jee/71.3.449 Published: 01 1978 history Received:...
Increased expression of linkage-specific 9-O-acetylated sialoglycans (9-O-AcSGs) has been demonstrated on erythrocytes from patients with visceral leishmaniasis (VL) by use Achatinin-H. We assessed the capacity this glycotope to influence hemolysis via activation alternative complement pathway in VL, compared that healthy control subjects.The differential 9-O-AcSGs surfaces was measured, were affinity purified, and molecular determinants identified Western blotting. The degree...
AbstractWe investigated population divergence in body melanisation wild samples of Drosophila melanogaster across an elevational gradient (512 - 2202m) the Western Himalayas. Wild populations are characterized by higher phenotypic variability as compared with laboratory populations. Significant differences slope values for three posterior abdominal segments (5th, 6th and 7th) versus suggest plastic effects. However, do not differ anterior (2nd, 3rd 4th). Thus, changes include genetic well...
The competitiveness carrying males of three genetic control systems for Aedes aegypti (L.), viz. chemosterilized males, double translocation heterozygote (T1T3) and distorter (DT1T3), released into a natural population in the Delhi metropolitanxarea was evaluated using method based on principle release recapture marked females. Chemosterilized DT1T3 showed approximately normal field which is similar to results obtained from laboratory cage experiments. T1T3 were found have reduced both...
Thermotolerance traits vary across geographical gradients but there is a lack of clinal variation in some Drosophila species. Thus, it not clear whether thermotolerance or other correlated are the target natural selection. In order to test selection responses, we investigated body melanization and six altitudinal populations melanogaster. Based on rearing different under uniform growth conditions at 21 °C (common garden experiments), variations for cold resistance direction opposite heat...
Utility of syndromic case management (SCM) in women visiting obstetrics & gynecology department needs to be evaluated as it is subjective and imperfect. Consequently, antibiotic resistance has accelerated along with increased risk infection the partners. To understand effectiveness and/or inadequacies SCM, 11000 were recruited examined by clinicians for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV), Bacterial vaginosis (BV) others. Amongst these patients,...
Silver nanoparticles (AgNPs) are extensively utilized in food, cosmetics, and healthcare products. Though the effects of AgNPs exposure on adults well documented, long-term gestational/perinatal upon health offspring have not been addressed. Herein, we show that only perinatal to through mother could lead chronic inflammation which persists till adulthood. Further, altered offspring's immune responses against environmental stresses. exposed showed an response splenocyte proliferation assay...
Abstract Chronic exposure to arsenic (As) promotes skin carcinogenesis in humans and potentially disturbs resident stem cell dynamics, particularly during maternal early life exposure. In the present study, we demonstrate how only prenatal keratinocyte (KSC) conditioning using a BALB/c mice model. Prenatal As alters normal stemness (CD34, KRT5), differentiation (Involucrin), proliferation (PCNA) program of offspring with progression age as observed at 2, 10, 18 weeks. Primary KSCs isolated...
In a malaria endemic area in Orissa state eastern India baseline (November 1989 to October 1990) incidence ranged from 215 328 cases/1,000 population/yr different groups of villages. November 1990, nylon bednets treated with deltamethrin at 25 mg/m2 were given out two villages (population 1062), untreated five 1,226) and one village 786) nets not given. Nets retreated 1991 June 1992 treated-net The trial continued until 1992. caused significant reduction indoor resting density, biting...
Male Culex pipiens fatigans were sterilized with thiotepa and released at a rate of 150,000-300,000 per day for five-and-a-half months into village near Delhi around which zone, 3km wide, was maintained free adult C.p. production by the application larvicides. The mosquitos release marked ratio (sterile) to unmarked (wild) males always greater than 24 : 1. In view known level mating competitiveness sterile very high proportion matings in expected be males. Data from egg rafts collected...
Abstract Ectothermic species face problems of water balance under colder and drier climatic conditions in montane localities. We investigated five ecophysiological traits (body melanization, desiccation resistance, rate loss or gain body size) eight populations Drosophila immigrans from an altitudinal gradient (600–2226 m) the Western Himalayas. The showed bell‐shaped variability patterns characteristic quantitative traits. For we observed high heritability (0.65) on basis parent–offspring...