A5002055063- Respiratory viral infections research
- Viral Infections and Immunology Research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Pneumonia and Respiratory Infections
- COVID-19 epidemiological studies
- COVID-19 and Mental Health
- Cytomegalovirus and herpesvirus research
- Infection Control and Ventilation
- Eosinophilic Disorders and Syndromes
- Bacterial Infections and Vaccines
- Immunodeficiency and Autoimmune Disorders
- Infectious Encephalopathies and Encephalitis
- Tracheal and airway disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Neonatal and Maternal Infections
- Infective Endocarditis Diagnosis and Management
- Nerve Injury and Rehabilitation
- Parvovirus B19 Infection Studies
- COVID-19 and healthcare impacts
- Childhood Cancer Survivors' Quality of Life
- Gestational Trophoblastic Disease Studies
- SARS-CoV-2 detection and testing
- Inflammasome and immune disorders
- Peripheral Nerve Disorders
Niigata University
2019-2025
Juntendo University Nerima Hospital
2025
National Center For Child Health and Development
2024-2025
Niigata University Medical and Dental Hospital
2018-2024
Oregon Medical Research Center
2024
New York Proton Center
2024
University of Pittsburgh
2024
Communities In Schools of Orange County
2024
Lindsay Unified School District
2024
Municipal Tsuruga Hospital
2018
In 2022–23, several European countries reported paediatric acute liver failure (ALF) with enterovirus infection. August–November 2024, three neonatal cases of ALF echovirus 11 (E11) were in Tokyo, Japan. All neonates developed irreversible multiple-organ and died. The E11 strain belonged to the new lineage 1, which was same as strains isolated from Europe 2022–23.
Invasive group A streptococcal (iGAS) infections are known to be potentially life-threatening. Few detailed pediatric cases of toxic shock syndrome (STSS) caused by iGAS with the M1UK strain have been reported. This report describes case a child STSS due strain, documentation treatment progress. 10-year-old female patient without predisposing factors associated iGAS, initially presented pneumonia and developed progressive multi-organ failure. precise diagnosis primary hospital's attending...
Background: The spread of the BA.5 Omicron variant severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has increased number hospitalized children. However, impact new omicron subvariants in children remains poorly described. Methods: This prospective observational study evaluated clinical characteristics with coronavirus disease 2019 (COVID-19) 13 hospitals Niigata, Japan, during September 2022–February 2024. data were divided and compared across 3 periods based on dominant...
Abstract Background The coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines were confirmed to be safe and effective, the original BNT162b2 mRNA vaccine for children aged 6 months 4 years was introduced in October 2022. However, COVID-19 vaccination coverage has been low children, especially among those years. Few studies have evaluated effectiveness (VE) this age group, no data are available from Japan. Methods A test-negative, case-control study conducted between April 2023 at...
In developing countries, acute gastroenteritis (AGE) is a leading cause of death in children younger than 5 years. Myanmar, no comprehensive study has been done to investigate the microorganisms responsible for AGE among hospitalized children. Multiplex polymerase chain reaction (PCR) was used identify Myanmar before introduction rotavirus vaccine. This prospective enrolled 12 years with who were at Yankin Children's Hospital Yangon, between September 2019 and February 2020. PCR (FilmArrayTM...
BACKGROUND SARS-CoV-2 can potentially cause nosocomial outbreaks. Although high secondary attack rates (SARs) among adult roommates have been reported, data on pediatric settings are limited. This study aimed to evaluate the SAR of symptomatic infections in shared rooms a children’s hospital. METHODS A retrospective chart review from January 1, 2023, December 31, was conducted at National Center for Child Health and Development, one largest tertiary hospitals Japan. According hospital...
Background: The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has dramatically altered the clinical profile pediatric disease 2019 (COVID-19). In Japan, we experienced a pandemic omicron subvariant BA.1/BA.2 from January through June 2022. However, after BA.5 in early July 2022, number children hospitalized with COVID-19 increased Japan. Methods: We collected data on monthly numbers cases and characteristics 13 hospitals, total cases, vaccination rates...
Acute lower respiratory infection (ALRI) remains the leading cause of death in children worldwide, and viruses have been major ALRI. In Myanmar, ALRI is associated with high morbidity mortality children, detailed information on currently lacking.
Enhanced surveillance of invasive pneumococcal disease (IPD) in adults was conducted during April 2013–March 2018 10 47 prefectures Japan, and a total 1277 IPD patients were enrolled. An emergence caused by serotype 12F identified May 2015–March through this surveillance. isolates composed four related sequence types. In total, 120 with reported period. To characterize the clinical features IPD, characteristics these compared those 1157 non-12F IPD. Compared patients, significantly lower...
Background: Enterovirus D68 (EV-D68) causes asthma-like respiratory infection in children. Several EV-D68 outbreaks have been reported worldwide since the largest outbreak occurred United States 2014. We experienced an accumulation of pediatric cases with illness Niigata, Japan, 2018. Study design: To determine whether was responsible for case accumulation, this prospective observational study evaluated children hospitalized 1 8 hospitals during October and November Diagnoses were made by...
Abstract Pneumococcal serotype replacement is an important issue after the introduction of pneumococcal conjugate vaccine (PCV) in children. After 13-valent PCV, incidence invasive diseases (IPD) caused by Streptococcus pneumoniae 12F (Sp12F) have increased some countries; however, outbreak Sp12F has not reported post-13-valent PCV era. We experienced a local during March through May 2016 Tsuruoka city, Japan 2013. The IPD patients were two children and seven adults, three whom died with...
Enterovirus D68 (EV-D68) causes a range of clinical manifestations, including asthma-like illness, severe respiratory disease, and acute flaccid myelitis. EV-D68 has caused worldwide outbreaks since 2014 is now recognized as reemerging infection in many countries. EV-D68-specific PCR assays are widely used for the diagnosis infection; however, assay sensitivity concern because genetic changes recently circulated EV-D68. To address this, we summarized sequences from previously reported world...
School closures are a subject of debate during the present coronavirus disease 2019 (COVID-19) pandemic. Because children not main driver COVID-19 transmission in community, school education must be prioritized conjunction with appropriate infection prevention and control measures, as determined by local incidence.We investigated causes routes primary cluster that occurred November December 2020 Niigata, Japan.In cluster, virus spread among teachers, then from teachers to students, their...
Spread of variants concerns (VOCs) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an increase in children with disease 2019 (COVID-19). In February 2021, clusters the Alpha variant SARS-CoV-2 started be reported Niigata, Japan, including a large nursery cluster. We investigated transmission routes and household secondary attack rates (SARs) this cluster.Epidemiologic data related cluster particularly child-origin adult-origin SARs, were analyzed. VOCs confirmed by...
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Vaccine hesitancy (VH) is a significant concern, although its specific characteristics remain unclear. Moreover, strategies to shift vaccine-hesitant parents' attitudes toward immunization are not yet well-defined. Pediatric emergency department (ED) physicians frequently encounter patients who inadequately vaccinated due parental VH; however, it challenging allocate sufficient time during ED visits provide comprehensive vaccination education. Our institution operates dedicated outpatient...
Abstract Background Information on the etiology and prognosis for leukemoid reaction (LR) in children is still limited little known about factors that distinguish LR from hematological malignancy (HM). Methods This was a single‐center, case–control study. Pediatric patients (<18 years) with white blood cell (WBC) count of 50,000/μL or more were included Clinical information laboratory test results extracted electronic medical records. Patients divided into HM groups. Logistic regression...
Enterovirus D68 (EV-D68) is an important reemerging pathogen that causes severe acute respiratory infection and flaccid paralysis, mainly in children. Since 2014, EV-D68 outbreaks have been reported the United States, Europe, east Asia; however, no southeast Asian countries, including Myanmar, during previous 10 years. was detected nasopharyngeal swabs from children with lower infections Myanmar. The samples were previously collected aged 1 month to 12 years who had admitted Yankin Children...
Human rhinovirus (HRV) has been sporadically detected in patients with acute flaccid myelitis (AFM). We report a case of AFM 2-year-old boy severe neurologic sequelae, whose nasopharyngeal and stool samples tested positive for HRV-A19. Clinical information related to HRV is limited. Further study the association warranted.
Abstract Parechovirus‐A (PeV‐A) causes emerging infection in children, and clinical presentation depends on genotype. The virus has been investigated mainly developed countries; however, data from developing countries, especially Asia, are sparse. This study whether PeV‐A circulated children Myanmar. retrospective evaluated nasopharyngeal samples aged 1 month to 12 years who were hospitalized with acute lower respiratory at Yankin Children Hospital, Yangon, Myanmar, during the period May...
Background: Human rhinovirus (HRV) was predominant and persistent during the coronavirus disease 2019 (COVID-19) pandemic despite nonpharmaceutical interventions. The data whether HRV persistence also occurred in neonates young infants were very limited. Methods: This prospective observational study conducted Niigata, Japan, between January 2020 September 2022. participants hospitalized less than 4 months of age with fever. We excluded patients evidence bacterial infection or obvious sick...
Abstract Data are limited on the incidence of coronavirus disease 2019 (COVID-19) reinfection in children. This population-based cohort study Niigata, Japan from January to November 2022 demonstrated was 1337/48 099 (2.8%), and hazard ratio for vaccinated children 0.29 (95% confidence interval, 0.20–0.40).
Incidences of community-acquired infectious diseases other than COVID-19 decreased during the coronavirus disease 2019 pandemic; however, exanthema subitum incidence before (2016–2019) and pandemic (2020) in Niigata, Japan, did not substantially differ, although proportion age less 1-year-old was lower 2020. These findings suggest that is transmitted mainly among family members, community.