A5037838194- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
- Evolutionary Algorithms and Applications
- Global Trade and Competitiveness
- Traumatic Brain Injury and Neurovascular Disturbances
- T-cell and B-cell Immunology
- vaccines and immunoinformatics approaches
- Hip and Femur Fractures
- Total Knee Arthroplasty Outcomes
- Gene Regulatory Network Analysis
- Biomedical and Engineering Education
- Bone fractures and treatments
- Genetics, Bioinformatics, and Biomedical Research
- Cell Image Analysis Techniques
- Immune Cell Function and Interaction
- Metabolomics and Mass Spectrometry Studies
- Metaheuristic Optimization Algorithms Research
- Nanowire Synthesis and Applications
Evolved Analytics (United States)
2019-2021
Significance Chronic nonunion following traumatic bone injury remains a challenging clinical problem, and delayed treatment of an established is associated with variable outcomes often prolonged patient disability. Here we used rodent model to investigate the factors that influence effective healing. We found certain immune profiles are linked impaired regeneration. In particular, increased early levels myeloid-derived suppressor cells cytokine interleukin-10 in blood predictive subsequent...
Advanced Manufacturing involves the manufacture of conventional or novel products through processes that depend on coordination information, automation, computation, software, sensing, and networking, and/or make use cutting edge materials emerging scientific capabilities.
Large-scale, reproducible manufacturing of therapeutic cells with consistently high quality is vital for translation to clinically effective and widely accessible cell therapies. However, the biological logistical complexity a living product, including challenges associated their inherent variability uncertainties process parameters, currently make it difficult achieve predictable cell-product quality. Using degradable microscaffold-based T-cell process, we developed an artificial...
Chimeric antigen receptor (CAR) T cells have demonstrated remarkable efficacy against hematological malignancies; however, they not experienced the same success solid tumors such as glioblastoma (GBM). There is a growing need for high-throughput functional screening platforms to measure CAR T-cell potency tumor cells.
Abstract Adoptive cell therapies (ACT) using chimeric antigen receptor (CAR) T cells have shown promise in treating cancer, but manufacturing large numbers of high quality remains challenging. Critically, current expansion technologies only partially recapitulate the vivo microenvironment found human lymph nodes. In these organs, expand at density with autocrine/paracrine signaling, as well signals from extracellular matrix (ECM). Here we describe a system degradable gelatin microcarriers...
Abstract Large-scale, reproducible manufacturing of therapeutic cells with consistently high quality is vital for translation to clinically effective and widely accessible cell therapies. However, the biological logistical complexity a living product, including challenges associated their inherent variability uncertainties process parameters, currently make it difficult achieve predictable cell-product quality. Using degradable microscaffold-based T as an example, we developed Artificial...
MODERATOR: Umay SaplakogluChief Digital Officer, CytivaTheresa KotanchekChief Executive Evolved Analytics LLCDamian MarshallDirector of New Technologies, Cell and Gene Therapy CatapultKrishnendu RoyDirector, Center for Immuno- Engineering, Georgia TechScott SobeckiDirector Research Informatics, Vanderbilt- Ingram Cancer