A5090928696- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- T-cell and B-cell Immunology
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
University of Oxford
2022-2023
MRC Weatherall Institute of Molecular Medicine
2022-2023
MRC Human Immunology Unit
2022
Walter Reed Army Institute of Research
2007
Background. Military personnel are at risk for acquiring Mycobacterium tuberculosis infection because of activities in close quarters and regions with a high prevalence (TB). Accurate tests needed to avoid unnecessary treatment false-positive results TB false-negative failure diagnose treat M. infection. We sought estimate the specificity tuberculin skin test (TST) 2 whole-blood interferon-γ release assays (QuantiFERON-TB assay [QFT] QuantiFERON-TB Gold [QFT-G]) identify factors associated...
Abstract Interactions with commensal microbes shape host immunity on multiple levels and play a pivotal role in human health disease. Tissue-dwelling, antigen-specific T cells are poised to respond local insults, making their phenotype important the relationship between microbes. Here we show that MHC-II restricted, commensal-reactive colon of both humans mice acquire transcriptional functional characteristics associated innate-like cells. This cell population is abundant conserved murine...
The relationship between gastrointestinal tract infection, the host immune response, and clinical outcome of disease is not well understood in COVID-19. We sought to understand effect intestinal responses SARS-CoV-2 on patient outcomes including magnitude systemic antibody induction. Combining two prospective cohort studies, International Severe Acute Respiratory emerging Infections Consortium Comprehensive Clinical Characterisations Collaboration (ISARIC4C) Integrated Network for...
Abstract Interactions with commensal microbes shape host immunity on multiple levels and are recognized to play a pivotal role in human health disease. In this study, we show that MHC-II restricted, commensal-reactive T cells the colon of both humans mice acquire transcriptional functional characteristics typically associated innate-like cells, including expression key transcription factor PLZF ability respond cytokines IL-12, IL-18 IL-23 TCR-independent manner. These M HC-II i nnate-like, c...