A5031134198- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiovascular Disease and Adiposity
- Eicosanoids and Hypertension Pharmacology
- Alzheimer's disease research and treatments
- Fatty Acid Research and Health
- Lipoproteins and Cardiovascular Health
- Cardiac Imaging and Diagnostics
- Protein Structure and Dynamics
- Supramolecular Self-Assembly in Materials
University of South Florida
2024
University College London
2000
Memorial University of Newfoundland
1999
In contrast to prevalent strategies which make use of β-sheet mimetics block Aβ fibrillar growth, in this study, we designed a series sulfonyl-γ-AApeptide helices that targeted the crucial α-helix domain Aβ13-26 and stabilized conformation avoid forming neurotoxic oligomeric β-sheets. Biophysical assays such as amyloid kinetics TEM demonstrated oligomerization fibrillation could be greatly prevented even reversed presence sulfonyl-γ-AApeptides sequence-specific dose-dependent manner. The...