A5019048796- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Antimicrobial Peptides and Activities
- Supramolecular Self-Assembly in Materials
- Carbohydrate Chemistry and Synthesis
- Antimicrobial agents and applications
- Environmental DNA in Biodiversity Studies
- Aquaculture disease management and microbiota
- Click Chemistry and Applications
- Microbial Community Ecology and Physiology
- Metal-Organic Frameworks: Synthesis and Applications
- Luminescence and Fluorescent Materials
- Alzheimer's disease research and treatments
- Biochemical and Structural Characterization
- Glycosylation and Glycoproteins Research
- Gut microbiota and health
- Species Distribution and Climate Change
- Nanoplatforms for cancer theranostics
- Protein Structure and Dynamics
- Monoclonal and Polyclonal Antibodies Research
- Advanced Nanomaterials in Catalysis
- Neuropeptides and Animal Physiology
- Bacteriophages and microbial interactions
- Isotope Analysis in Ecology
University of South Florida
2017-2024
Georgia Southern University
2020-2024
University of West Alabama
2018
Hydantoin (imidazolidinedione) derivatives such as nitrofurantoin are small molecules that have aroused considerable interest recently due to their low rate of bacterial resistance. However, moderate antimicrobial activity may hamper application combating antibiotic resistance in the long run. Herein, we report design membrane-active hydantoin derivatives, from which identified compounds show much more potent than against a panel clinically relevant Gram-positive and Gram-negative strains....
Foldamers have defined and predictable structures, improved resistance to proteolytic degradation, enhanced chemical diversity, are versatile in their mimicry of biological molecules, making them promising candidates biomedical material applications. However, as natural macromolecules exhibit endless folding structures functions, the exploration applications foldamers remains crucial. As such, it is imperative continue discover unnatural foldameric architectures with new frameworks molecular...
New types of foldamer scaffolds are formidably challenging to design and synthesize, yet highly desirable as structural mimics peptides/proteins with a wide repertoire functions. In particular, the development peptidomimetic helical foldamers holds promise for new biomaterials, catalysts, drug molecules. Unnatural l-sulfono-γ-AApeptides were recently developed shown have potential applications in both biomedical material sciences. However, d-sulfono-γ-AApeptides, enantiomers...
Abstract The development of peptidomimetic helical foldamers with a wide repertoire functions is significant interest. Herein, we report the X‐ray crystal structures series homogeneous l ‐sulfono‐γ‐AA and elucidate their folding conformation at atomic level. Single‐crystal crystallography revealed that this class oligomers fold into unprecedented dragon‐boat‐shaped unexpected left‐handed helices, which are stabilized by 14‐hydrogen‐bonding pattern present in all sequences. These...
In contrast to prevalent strategies which make use of β-sheet mimetics block Aβ fibrillar growth, in this study, we designed a series sulfonyl-γ-AApeptide helices that targeted the crucial α-helix domain Aβ13-26 and stabilized conformation avoid forming neurotoxic oligomeric β-sheets. Biophysical assays such as amyloid kinetics TEM demonstrated oligomerization fibrillation could be greatly prevented even reversed presence sulfonyl-γ-AApeptides sequence-specific dose-dependent manner. The...
Existing long α-helix mimicking necessitates the retention of most natural amino acid residues to maintain their biological activity. Here, we report exploration helical sulfono-γ-AApeptides with entire unnatural backbones for ability structurally and functionally mimic glucagon-like peptide 1 (GLP-1). Our findings suggest that efficient construction novel GLP-1 receptor (GLP-1R) agonists could be achieved nanomolar potencies. In addition, resulting were also proved display remarkable...
Identification of molecular ligands that recognize peptides or proteins is significant but poses a fundamental challenge in chemical biology and biomedical sciences. Development cyclic peptidomimetic library scarce, thus discovery for protein targets rare. Herein we report the unprecedented one-bead–two-compound (OBTC) combinatorial based on novel class macrocyclic peptidomimetics γ-AApeptides. In library, utilized coding peptide tags synthesized with Dde-protected α-amino acids, which were...
Abstract Through continuous efforts in developing a new class of foldamers, homogeneous sulfono‐γ‐AApeptides have been designed and synthesized using tetraphenylethylene (TPE) moieties attached to the backbone as luminogenic sidechains. Based on previous crystal structures, it is found that these foldamers adopted left‐handed 4 14 ‐helix. Due constraint helical scaffold, rotation TPE restricted, leading fluorescent emissive properties with high quantum yields not only at aggregate state but...
Peptidomimetics have gained great attention for their function as protein–protein interaction (PPI) inhibitors. Herein, we report the design and investigation of a series right-handed helical heterogeneous 1:1 α/Sulfono-γ-AA peptides unprecedented inhibitors p53-MDM2 p53-MDMX. The most potent were shown to bind tightly MDM2 MDMX, with Kd 19.3 66.8 nM, respectively. Circular dichroism spectra, 2D-NMR spectroscopy, computational simulations suggested that these sulfono-γ-AA could mimic...
Comparing co-occurring species may provide insights into how aspects of ecology play a role in influencing their microbial communities. During the 2019 commercial shrimp trawl season off coastal Georgia, swabs skin, gills, cloaca, and gut were taken for three batoids (Butterfly Ray, Bluntnose Stingray, Atlantic Stingray) one shark (Atlantic Sharpnose) high-throughput sequencing V4 region bacterial 16S rRNA gene. White muscle was analyzed stable isotopes (δ13C δ15N) to evaluate potential...
Abstract The development of peptidomimetic helical foldamers with a wide repertoire functions is significant interest. Herein, we report the X‐ray crystal structures series homogeneous l ‐sulfono‐γ‐AA and elucidate their folding conformation at atomic level. Single‐crystal crystallography revealed that this class oligomers fold into unprecedented dragon‐boat‐shaped unexpected left‐handed helices, which are stabilized by 14‐hydrogen‐bonding pattern present in all sequences. These...
Over the past few decades, emergence of antibiotic resistance developed by life-threatening bacteria has become increasingly prevalent. Thus, there is an urgent demand to develop novel antibiotics capable mitigating this trend. Herein we reported a series dimeric γ-AApeptide derivatives as potential agents with limited toxicity and excellent selectivity against Gram-positive strains. Among them, compound 2 was identified have best MICs without inducing drug even after exposure MRSA for 20...
Abstract Metal‐organic framework (MOF) compounds ZIF‐8 and Uio‐66 were synthesized by the solvent‐thermal method; then loaded with silver nanoparticles studied to determine their adsorption of formaldehyde gas. The results showed that when loading was 2.5 wt%, Ag NPs@ZIF‐8 had highest rate for gas, capacity 8.2‐11.5 times greater than ZIF‐8. When nanoparticle 5 NPs@Uio‐66 gas 1.75 higher Uio‐66.
Interest in gut microbial community composition has exploded recently as a result of the increasing ability to characterize these organisms and growing understanding their role host fitness. New technologies, such next generation amplicon (16S rRNA) sequencing, have enabled identification bacterial communities from samples diverse origin (e.g., fecal, skin, genital, environmental, etc.). Relatively little work, however, explored feasibility utilizing historical museum archived samples)...
The bacteriophage Demsculpinboyz was discovered in a soil sample from the Black Belt region of Alabama using Mycobacterium smegmatis mc2155 as its host. genome is 57,437 bp long and contains 116 protein-coding genes. It belongs to F2 subcluster, which has only five other members.