A5068628225- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Ubiquitin and proteasome pathways
- Diabetes Treatment and Management
- Chemical Synthesis and Analysis
- Oral and Maxillofacial Pathology
- Sarcoma Diagnosis and Treatment
- Peroxisome Proliferator-Activated Receptors
- RNA and protein synthesis mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- Plant Genetic and Mutation Studies
- Genetics and Neurodevelopmental Disorders
- Pharmacology and Obesity Treatment
- Peptidase Inhibition and Analysis
- Bone Tumor Diagnosis and Treatments
- Pharmacological Effects of Natural Compounds
- Protein Degradation and Inhibitors
- Optical Imaging and Spectroscopy Techniques
- Cancer Diagnosis and Treatment
- Neuroendocrine regulation and behavior
- Inflammatory Bowel Disease
- RNA modifications and cancer
- Neuroscience of respiration and sleep
- Epigenetics and DNA Methylation
- Gut microbiota and health
Nanchang University
2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
Second Affiliated Hospital of Nanchang University
2024
Wuhan Union Hospital
2021
Scripps Research Institute
2018-2020
California Institute for Biomedical Research
2018-2020
Scripps Institution of Oceanography
2020
Scripps (United States)
2020
Hunan Sports Bureau
2018
Existing long α-helix mimicking necessitates the retention of most natural amino acid residues to maintain their biological activity. Here, we report exploration helical sulfono-γ-AApeptides with entire unnatural backbones for ability structurally and functionally mimic glucagon-like peptide 1 (GLP-1). Our findings suggest that efficient construction novel GLP-1 receptor (GLP-1R) agonists could be achieved nanomolar potencies. In addition, resulting were also proved display remarkable...
Bariatric surgery results in increased intestinal secretion of hormones GLP-1 and anorexigenic PYY, which is believed to contribute the clinical efficacy associated with procedure. This observation raises question whether combination treatment gut hormone analogs might recapitulate mitigate significant risks surgery. Despite PYY demonstrating excellent safety profiles regard food intake reduction, weight loss, glucose control preclinical animal models, PYY-based therapeutic development...
The effects of oxytocin on food intake and body weight reduction have been demonstrated in both animal models human clinical studies. Despite being efficacious, is enzymatically unstable thus considered to be unsuitable for long-term use patients with obesity. Herein, a series derivatives were engineered through conjugation fatty acid moieties that are known exhibit high binding affinities serum albumin. One analog (OT-12) particular was shown potent full agonist at the receptor (OTR) vitro...
Owing to their pleiotropic metabolic benefits, glucagon-like peptide-1 receptor (GLP-1R) agonists have been successfully utilized for treating diseases, such as type 2 diabetes and obesity. As part of our efforts in developing long-acting peptide therapeutics, we previously reported a engineering strategy that combines side chain stapling with covalent integration serum protein-binding motif single step. Herein, used this develop second generation extendin-4 analog rigidified symmetrical...
Proteolysis-targeting chimeras (PROTACs) have played an important role in the development of protein-targeted degradation drugs. However, effective tools are urgently required for further and validation PROTACs. We developed a high-potency reporter (AKT-PROTAC-Reporter; APR) PROTACs that specifically targets AKT. The APR successfully detected status levels AKT-PROTAC-CRBN ternary complex vivo vitro. is based on bimolecular fluorescence complementation system, where EGFP luciferase were used...
Objective To evaluate the effects of Living-High Training-Low on HIF-1α transcriptional regulatory factors MAPKs mRNA in gastrocnemius Rats.
 Methods After adaptive training, 40 8-weeks-old male SD rats were divided into living-low quiet control group (LC), training-low (LoLo), living-high (HC), (HiLo). All groups stayed environment with 13.6% oxygen concentration, about altitude 3500 m, for 12h/day. training underwent treadmill 35m/min 1hour/day, 5days/week. 4 weeks later, was sampled...
Objective Analysis of the level very long chain fatty acids in plasma X-linked adrenoleukodystrophy and discussion its relation with mutation gene. Methods 28 ALD hemizygotes 9 heterozygotes collected from May 2013 to March 2017 were enrolled this study. Concentrations VLCFAs quantitatively analyzed ABCD1 gene sequenced. Results ①The concentration 26: 0, C24: 0/C22: C26: 0 significantly different among hemizygotes, control groups (P=0.000, respectively). concentrations had...