A5028344582- Pain Mechanisms and Treatments
- Endodontics and Root Canal Treatments
- Dental Radiography and Imaging
- Neuropeptides and Animal Physiology
- Dental Anxiety and Anesthesia Techniques
- Dental Trauma and Treatments
- Neurobiology and Insect Physiology Research
- Ion Channels and Receptors
- Plant-based Medicinal Research
- Musculoskeletal pain and rehabilitation
- Anesthesia and Pain Management
- Respiratory and Cough-Related Research
- Spine and Intervertebral Disc Pathology
- Photochemistry and Electron Transfer Studies
- Pediatric Pain Management Techniques
- Periodontal Regeneration and Treatments
- Nerve injury and regeneration
- Temporomandibular Joint Disorders
- Intramuscular injections and effects
- Immune Response and Inflammation
- Molecular spectroscopy and chirality
- Trigeminal Neuralgia and Treatments
- Pain Management and Opioid Use
- Inflammatory mediators and NSAID effects
- Synthesis and Properties of Aromatic Compounds
Harvard University
2019-2025
New York University
2014-2024
Good Samaritan Hospital Medical Center
2016-2018
American Association of Endodontists
1998-2015
St George’s University Hospitals NHS Foundation Trust
2015
University of California, San Francisco
2008-2013
Center for Clinical Research (United States)
2011
Rutgers, The State University of New Jersey
2011
The University of Texas Health Science Center at San Antonio
2004-2008
Trinity University
1998
On Twitter, people answer the question, “What are you doing right now?” in no more than 140 characters. We investigated content of Twitter posts meeting search criteria relating to dental pain. A set 1000 tweets was randomly selected from 4859 over 7 non-consecutive days. The coded using pre-established, non-mutually-exclusive categories, including experience pain, actions taken or contemplated response a toothache, impact on daily life, and advice sought community. After excluding ambiguous...
Cancers often cause excruciating pain and rapid weight loss, severely reducing quality of life in cancer patients. Cancer-induced cachexia are studied treated independently, although both symptoms strongly linked with chronic inflammation sustained production proinflammatory cytokines. Because nerve growth factor (NGF) plays a cardinal role pain, because it interacts multiple cytokines, we hypothesized that NGF acts as key endogenous molecule involved the orchestration cancer-related...
Hypersensitivity to thermal and mechanical stimuli can occur in painful pulpitis. To explore the neuro-anatomical basis of heat sensitivity, we evaluated expression TRPV1 (heat) TRPV2 (heat/mechanical) channels cell bodies terminal arborizations neurons that innervate dental pulp (DP) periodontal tissues (PDL). We report ~50% trigeminal ganglion (TG) retrogradely labeled from DP express TRPV2, this was significantly greater than general channel TG (15%) slightly more what is expressed PDL by...
Persistent pain can occur after routine dental treatments in which the pulp is injured. To better understand chronicity injury, we assessed whether injury mice causes changes to sensory nervous system associated with pathological pain. In some experiments, compared findings a model of orofacial neuropathic pain, mental nerve After unilateral observed increased expression activating transcription factor 3 (ATF3) and neuropeptide Y (NPY) mRNA decreased tachykinin precursor 1 gene expression,...
Abstract Injury of the tooth pulp is excruciatingly painful and yet receptors neural circuit mechanisms that transmit this form pain remain poorly defined in both clinic preclinical rodent models. Easily quantifiable behavioral assessment mouse orofacial area remains a major bottleneck uncovering molecular govern inflammatory tooth. In study we sought to address problem using Mouse Grimace Scale novel approach application mechanical Von Frey hair stimuli. We use dental injury model exposes...
Dental pain is a persistent, detrimental public health issue that requires better understanding of the mechanisms tooth and inflammation in order to develop more effective treatments. Calcitonin gene-related peptide (CGRP) dental pulp cells are promising candidates for mediating generating reparative tissues, respectively, but their behavior context pulpitis remains elusive. The mouse incisor Sonic hedgehog (Shh) secreted from sensory nerves continuously regenerate. However, it unknown...
Neuropeptide Y (NPY) and its cognate receptors are important modulators of nociception their expression is significantly altered following injury. In particular, previous studies have demonstrated that the Y1 subtype NPY inhibits nociceptive transmission from capsaicin-sensitive terminals in dorsal horn spinal cord. The present study evaluated function receptor on peripheral primary afferent neurons by testing whether peripherally administered agonists antagonists alter capsaicin-evoked...
Sensory neurons innervating the dental pulp have unique morphological and functional characteristics compared to other tissues. Stimulation of afferents whatever modality or intensity stimulus, even light mechanical stimulation that would not activate nociceptors in tissues, produces an intense pain. These specific sensory could involve receptors Transient Receptor Potential channels (TRP) family. In this study, we expression cold sensitive TRPM8 TRPA1 trigeminal ganglion pulp, skin cheek...