Chronic pancreatitis in toddlers presents typically by epigastric pain with radiation to the back, steatorrhea, or chronic weight loss despite adequate nutrition, nausea, vomiting, and/or diarrhea. Among adult almost 10% do not report pain. We a 21-month-old boy who presented jaundice, clay colored stool, elevated liver enzymes, and hepatomegaly. The mother reported that child had no complaints otherwise. Hepatitis A virus IgM was positive. He advised conservative treatment response. Two...

Abstract Background and aim: Many studies have examined the nature of tissue formed in canals immature necrotic teeth, following revascularization animals humans. While speculations been made that regeneration pulp might take place canal, has found to be cementum‐like, bone‐like, periodontal ligament‐like. The purpose this study was histologically examine root dog teeth had artificially infected then revascularized. Methods Two 4‐ 5‐month‐old mongrel dogs with were used study. In one dog,...

Herein, a set of pyridine and pyrimidine derivatives were assessed for their impact on the cell cycle apoptosis. Human breast cancer (MCF7), hepatocellular carcinoma (HEPG2), larynx (HEP2), lung (H460), colon cancers (HCT116 Caco2), hypopharyngeal (FADU), normal Vero lines used. Compounds 8 14 displayed outstanding effects investigated further tested antioxidant activity in MCF7, H460, FADU, HEP2, HEPG2, HCT116, Caco2, cells by measuring superoxide dismutase (SOD), malondialdehyde content...

Background and aim: Salivary gland tumors constitute three percent of in the head neck region, with eighty these originating parotid gland. The study aimed to evaluate clarify use PI-RADS Scoring system FNAC diagnosing lesions compare it post-operative histo-pathological diagnosis.Patients methods: This was an observational conducted on patients presented swelling out-patient clinic endocrine surgery unit at Mansoura University hospital. between October 2021 end 2024.Results: PIRADS used...

Abstract Egypt, for its location in the northeastern corner of Africa, is exposed to continuous tectonic activities. To North, subduction oceanic African plate under Eurasian provides a seismic activity along Hellenic and Cyprian arcs. East, Egypt affected by divergence between Arabian plates Red Sea. The E-W fault trend one three main trends it starts at northern tip Gulf Suez towards Cairo. Moreover, government planning expand economically development Cairo-Suez Province. Most new housing...

Cancer, as a group, represents the most important cause of death worldwide. Unfortunately, available therapeutic approaches cancer including surgery, chemotherapy, radiotherapy, and immunotherapy are unsatisfactory represent great challenge many patients have recurrence severe side effects. Methotrexate (MTX) is well-established (antineoplastic or cytotoxic) chemotherapy immunosuppressant drug used to treat different types cancer, but its usage requires high doses causing Therefore, we need...

Despite the extraordinary use of silver nanoparticles (AgNPs) in medicinal purposes and food industry, there is rising worry about potential hazards to human health environment. The existing study aims assess hepatotoxic effects different dosages AgNPs by evaluating hematobiochemical parameters, oxidative stress, liver morphological alterations, immunohistochemical staining, gene expression clarify mechanism AgNPs' hepatic toxic potential. Forty male Sprague Dawley rats were randomly...

Abstract Background Usually, wounds recover in four to six weeks. Wounds that take longer time than this heal are referred as chronic wounds. Impaired healing can be caused by several circumstances like hypoxia, microbial colonization, deficiency of blood flow, reperfusion damage, abnormal cellular reaction and deficiencies collagen production. Treatment enhanced through systemic injection the antibacterial drugs and/or other topical applications medications. However, there a number...

Acinetobacter baumannii (A. baumannii) is an important pathogen that causes hospital-acquired illnesses worldwide. The biofilm-forming activity of the organism enhances its capacity to acquire significant levels antibiotic resistance, hence necessitating development novel and effective antibacterial drugs. Nevertheless, nanoparticles have been documented as highly agents against bacterial growth biofilm formation. So, purpose this work was study antibiofilm capabilities silver synthesized by...

Background . Nephrotoxicity of cisplatin has been recognized since its introduction more than 25 years ago. However, despite intense efforts to develop less toxic and equally effective alternatives, continues be widely prescribed. Aim Objectives The study is aimed at assessing the possible prophylactic effect coenzyme Q10 (CoQ10) alpha-lipoic acid (ALA) (separately or in combination) on experimentally cisplatin-induced nephrotoxicity. Subjects Methods An experimental was performed adult male...

The development of nanoparticles (NPs) with active components upgraded stability, and prolonged release helps in enhanced tissue regeneration. In addition, NPs are feasible strategy to boost antibiotic effectiveness reduce drug side effects. Our study focuses on the use amikacin (AMK) gamma amino butyric acid (GABA) unloaded combinations or loaded chitosan (CSNPs) for kidney protection. AMK-GABA-CSNPs were prepared ionic gelation method, morphology was studied using transmission electron...

Although the frequent respiratory affection in COVID-19, it is well established that could be presented with a wide variation of gastrointestinal symptoms; however, effect on pancreas remains unclear.We report case female patient, who was diagnosed COVID-19 infection. A week later, patient developed an attack acute pancreatitis. Other causes pancreatitis were excluded. Therefore, this attributed to SARS-COV2 infection.The raises awareness about possibility COVID-19. Also emphasize importance...

Type 2 diabetes mellitus (T2DM) is mainly characterized by insulin resistance and impaired secretion, which cannot be reversed with existing therapeutic strategies. Using mesenchymal stem cells (MSCs), cell‐based therapy has been demonstrated in displaying effects T2DM for their self‐renewable, differentiation potential, immunosuppressive properties higher levels of angiogenic factors. Stem cell therapies are complicated have a serious adverse effect including tumor formation immunogenicity,...

In this study, temperature-responsive polymer-protein conjugate was synthesized using a “grafting from” concept by introducing chain transfer agent (CTA) into bovine serum albumin (BSA). The BSA-CTA used as starting point for poly(N-isopropylacrylamide) (PNIPAAm) through reversible addition-fragmentation polymerization. research investigations suggest that the thermally responsive behavior of PNIPAAm controlled monomer ratio to CTA, well amount CTA introduced BSA. study further human...

Background— Cardiac output (CO) is a key indicator of cardiac function in patients with heart failure. No completely accurate method available for measuring CO all patients. The objective this study was to validate measurement using the inert gas rebreathing (IGR) against other noninvasive and invasive methods quantification cohort failure reduced ejection fraction. Methods Results— included 97 fraction (age 42±15.5 years; 64 (65.9%) had idiopathic dilated cardiomyopathy 21 (21.6%) ischemic...

Egyptian poultry suffer from frequent respiratory disease outbreaks associated with Infectious Bronchitis Virus (IBV) variant 2 strains (Egy/VarII). Different vaccination programs using imported vaccines have failed to protect the flocks field challenge. Recent studies confirmed a successful protection homologous as live attenuated vaccines. In this study, newly developed IB-VAR2 vaccine representing GI-23 Middle East IBV lineage was evaluated in day-old commercial broilers an IBV-endemic...

Mercury is a global environmental pollutant, accumulating mainly in the kidney and liver inducing hepatorenal toxicity, oxidative stress, tissue damage. Oxidative stress caused by an imbalance between free radicals’ production cellular antioxidant defense systems. In present study, we investigated effect of N N′-diphenyl-1, 4-phenylenediamine (DPPD) activity against mercury chloride- (HgCl 2 -) induced renal hepatic toxicity. Thirty adult female Sprague Dawley rats were divided into three...

Liver fibrosis is the excessive extracellular matrix accumulation of proteins, such as collagen, which follows chronic liver diseases. Advanced leads to cirrhosis and failure. Nilotinib a second-generation tyrosine kinase inhibitor, showed antifibrotic efficacy. Stem cell therapy still has some limitations oncogenesis, unexpected differentiation, ethical consideration. cells secrete cytokines growth factors that paracrine-mediated anti-inflammatory effects in vivo vitro. Thus, stem...

In medicine, silver nanoparticles (AgNPs) are employed often. They do, however, have negative impacts, particularly on the reproductive organs. This research aimed to assess AgNP impact testis and possible intracellular mechanisms induce testicular deteriorations in rats at various concentrations different time intervals. Sprague Dawley (n = 40) were allocated into four equal groups: control one, three other groups injected intra-peritoneally with solution 0.25, 0.5, 1 mg/kg b.w....

Anticancer drug resistance invariably emerges and poses a significant barrier to curative therapy for various breast cancers. This results in lack of satisfactory therapeutic medicine cancer treatment. Herein, universal vector system drug-resistance was designed meet the needs reversed multidrug resistance, thermo-chemotherapy, long-term release behavior. The comprises polycaprolactone (PCL) nanofiber mesh magnetic nanoparticles (MNPs). PCL has excellent biocompatibility electrospinning...