A5049846376- Electrospun Nanofibers in Biomedical Applications
- Hydrogels: synthesis, properties, applications
- Advanced Sensor and Energy Harvesting Materials
- 3D Printing in Biomedical Research
- Nanoparticle-Based Drug Delivery
- Polymer composites and self-healing
- Polymer Surface Interaction Studies
- RNA Interference and Gene Delivery
- Advanced Materials and Mechanics
- Cellular Mechanics and Interactions
- Advanced Polymer Synthesis and Characterization
- Bone Tissue Engineering Materials
- Tissue Engineering and Regenerative Medicine
- Phagocytosis and Immune Regulation
- Advanced biosensing and bioanalysis techniques
- Microfluidic and Capillary Electrophoresis Applications
- Supramolecular Self-Assembly in Materials
- biodegradable polymer synthesis and properties
- Surface Modification and Superhydrophobicity
- Photochromic and Fluorescence Chemistry
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- Graphene and Nanomaterials Applications
National Institute for Materials Science
2016-2025
University of Tsukuba
2016-2025
Tokyo University of Science
2016-2025
Advanced Engineering (Czechia)
2021-2024
Institute of Molecular Functional Materials
2022
University of Washington
2006-2021
Materials Science & Engineering
2017
World Precision Instruments (United States)
2015-2016
Osaka University Hospital
2009-2013
Seattle University
2006-2010
Abstract A smart hyperthermia nanofiber is described with simultaneous heat generation and drug release in response to ‘on‐off’ switching of alternating magnetic field (AMF) for induction skin cancer apoptosis. The composed a chemically‐crosslinkable temperature‐responsive polymer an anticancer (doxorubicin; DOX) nanoparticles (MNPs), which serve as trigger source heat, respectively. By chemical crosslinking, the mesh shows switchable changes swelling ratio switches AMF because...
In this study, specific interactions between immobilized RGDS (Arg-Gly-Asp-Ser) cell adhesion peptides and integrin receptors located on membranes are controlled in vitro using stimuli-responsive polymer surface chemistry. Temperature-responsive poly(N-isopropylacrylamide-co-2-carboxyisopropylacrylamide) (P(IPAAm-co-CIPAAm)) copolymer grafted onto tissue culture grade polystyrene (TCPS) dishes permits immobilization. These surfaces facilitate the spreading of human umbilical vein endothelial...
Shape-memory surfaces with on-demand, tunable nanopatterns are developed to observe time dependent changes in cell alignment using temperature-responsive poly(ϵ-caprolactone) (PCL) films. Temporary grooved easily programmed on the films and triggered transition quickly permanent surface patterns by application of body heat. A time-dependent cytoskeleton remodeling is also observed under biologically relevant conditions.
A stimuli-responsive magnetic nanoparticle system for diagnostic target capture and concentration has been developed microfluidic lab card settings. Telechelic poly(N-isopropylacrylamide) (PNIPAAm) polymer chains were synthesized with dodecyl tails at one end a reactive carboxylate the opposite by reversible addition fragmentation transfer technique. These PNIPAAm self-associate into nanoscale micelles that used as dimensional confinements to synthesize nanoparticles. The resulting...
Stem cell responsiveness to extracellular matrix (ECM) composition and mechanical cues has been the subject of a number investigations so far, yet molecular mechanisms underlying stem mechano-biology still need full clarification. Here we demonstrate that paralog proteins YAP TAZ exert crucial role in adult cardiac progenitor mechano-sensing fate decision. Cardiac progenitors respond dynamic modifications substrate rigidity nanopattern by promptly changing YAP/TAZ intracellular localization....
Bioinspired nanoarchitectonics opens a new era for designing drug delivery systems.
There is a need to develop simple, cheap, and accessible method of treating patients with kidney failure, especially in resource-limited environments such as disaster areas the developing world due inaccessibility conventional hemodialysis treatments. In this study, we zeolite-polymer composite nanofiber mesh remove uremic toxins for blood purification. The composed compatible poly(ethylene-co-vinyl alcohol) (EVOH) primary matrix polymer zeolites which are capable selectively adsorbing...
We propose a new approach to fabricate reversible self-bending actuators utilizing photo-triggered pH jump reaction. A photo-initiated proton-releasing agent of o-nitrobenzaldehyde (NBA) was successfully integrated into bilayer hydrogels composed polyacid layer, poly(N-isopropylacrylamide-co-2-carboxyisopropylacrylamide) (P(NIPAAm-co-CIPAAm)) and polybase poly(N-isopropylacrylamide-co-N,N′-dimethylaminopropylacylamide) (P(NIPAAm-co-DMAPAAm)), where the adhesion both layers achieved via...
Carbon nanoarchitectures derived from biobased building blocks are potential sustainable alternatives to electrode materials generated with petroleum-derived resources. We aim at developing a fundamental understanding on the connection between structure and electrochemical performance of porous carbon nanofiber (PCNF) architectures polysaccharide chitosan as block. fabricated range PCNF precursor tailored their by varying amount molecular weight sacrificial pore-forming polymer poly(ethylene...
Acrylic acid (AAc) has been utilized to introduce reactive carboxyl groups a temperature-responsive polymer, poly(N-isopropylacrylamide) (PIPAAm). However, AAc introduction shifts the copolymer phase transition temperatures higher and dampens steep homopolymer with increasing content. We previously synthesized 2-carboxyisopropylacrylamide (CIPAAm) having both similar side chain structure IPAAm functional carboxylate group in order overcome these shortcomings. In present study, copolymers,...
Abstract To introduce reactive groups into temperature-responsive polymeric chains of poly(N-isopropylacrylamide) (PIPAAm), IPAAm is copolymerized with other monomer such as acrylic acid (AAc). homopolymer exhibited properties and phase transition at 32°C, however, the lower critical solution temperature (LCST) IPAAm-AAc copolymer shifts to a higher becomes insensitive increasing AAc content. achieve useful bifunctional containing both reactivity temperature-sensitivity, we assumed that...
We report here a reversible microchannel surface capture system for stimuli-responsive grafted bioanalytical beads. Poly(N-isopropylacrylamide) (PNIPAAm) was onto polydimethylsiloxane (PDMS) surfaces by UV-mediated graft polymerization from photoinitiator that preadsorbed in the channel wall. The grafting density and resulting switchable hydrophilic/hydrophobic properties were controlled varying photo-illumination times and/or initiator concentration. At limiting PNIPAAm-graft densities,...
Biomaterials to be used as cell delivery systems for cardiac tissue engineering should able comply with muscle contractile activity, while favoring survival and neo-angiogenesis in a hostile environment. Biocompatible synthetic materials can tailored mimic three-dimensional organization the micro- nanoscales. Nonetheless, they usually display mechanical properties that are far from those of native myocardium thus could affect host activity. In present investigation, inert poly-ɛ-caprolactone...
Caught in a web: Photo-cross-linkable temperature-responsive polymer-based nanofiber webs have been synthesized that the ability to capture, encapsulate, and release cells by dynamically transforming fibrous structure into hydrogel-like structures wrapping, swelling, deswelling processes response external temperature changes (see picture).
Plasmonic nanoparticles can confine light in nanoscale and locally heat the surrounding. Here we use titanium nitride (TiN) as broadband plasmonic absorbers synthesized a highly photoresponsive hybrid cross-linked polymer from shape memory poly(ε-caprolactone) (PCL). The TiN–PCL is responsive to sunlight threshold irradiance was among lowest when compared with other polymers studied previously. Sunlight heating TiN NPs be applied smart polymers, thereby contributing energy-saving research...
This study aims to propose a new treatment model for glioblastoma (GBM). The combination of chemotherapy, molecular targeted therapy and radiotherapy has been achieved in highly simultaneous manner through the application safe, non-toxic, locally sustained drug-releasing composite Nanofiber mesh (NFM). NFM consisted biodegradable poly(ε-caprolactone) with temozolomide (TMZ) 17-allylamino-17-demethoxygeldanamycin (17AAG), which was used radiation treatment. TMZ 17AAG showed synergistic...
Introduction of significant quantities functional carboxyl groups into temperature-responsive poly(N-isopropylacrylamide) (PIPAAm) hydrogels without compromising their intrinsic temperature sensitivity has proven difficult. We have overcome this problem by incorporating the newly synthesized 2-carboxyisopropylacrylamide (CIPAAm) monomer, with a side chain structure similar to N-isopropylacrylamide (IPAAm). Hydrogels containing more than 10 mol % CIPAAm exhibit large and sensitive volume...