A5075395920- Photosynthetic Processes and Mechanisms
- Microbial Community Ecology and Physiology
- Algal biology and biofuel production
- Microbial Fuel Cells and Bioremediation
- Biocrusts and Microbial Ecology
- Environmental Toxicology and Ecotoxicology
- Microbial Metabolic Engineering and Bioproduction
- Trace Elements in Health
- Advanced Nanomaterials in Catalysis
- Marine Toxins and Detection Methods
- RNA modifications and cancer
- Heavy Metal Exposure and Toxicity
- Redox biology and oxidative stress
- Clostridium difficile and Clostridium perfringens research
- Heavy metals in environment
- Metal-Catalyzed Oxygenation Mechanisms
- Potassium and Related Disorders
- Machine Learning in Bioinformatics
- Aquatic Ecosystems and Phytoplankton Dynamics
- Protist diversity and phylogeny
- Microbial bioremediation and biosurfactants
Universidad de Zaragoza
2019-2024
Instituto de Biocomputación y Física de Sistemas Complejos
2024
Haloferax mediterranei, an extreme halophilic archaeon thriving in hypersaline environments, has acquired significant attention biotechnological and biochemical research due to its remarkable ability flourish salinity conditions. Transcription factors, essential regulating diverse cellular processes, have become focal points understanding adaptability. This study delves into the role of Lrp transcription factor, exploring modulation glnA, nasABC, lrp gene promoters vivo through...
Clostridioides (formerly Clostridium) difficile is a leading cause of infectious diarrhea associated with antibiotic therapy. The ability this anaerobic pathogen to acquire enough iron proliferate under limitation conditions imposed by the host largely determines its pathogenicity. However, since high intracellular catalyzes formation deleterious reactive hydroxyl radicals, uptake tightly regulated at transcriptional level ferric regulator Fur. Several studies relate lacking functional fur...
FurC (PerR) from Anabaena sp. PCC7120 was previously described as a key transcriptional regulator involved in setting off the oxidative stress response. In last years, cross-talk between stress, iron homeostasis and nitrogen metabolism is becoming more evident. this work, transcriptome of furC-overexpressing strain compared with that wild-type under both standard nitrogen-deficiency conditions. The results showed overexpression furC deregulates genes several categories standing out...
Zinc is required for the activity of many enzymes and plays an essential role in gene regulation redox homeostasis. In Anabaena (Nostoc) sp. PCC7120, genes involved zinc uptake transport are controlled by metalloregulator Zur (FurB). Comparative transcriptomics a zur mutant (Δzur) with parent strain unveiled unexpected links between homeostasis other metabolic pathways. A notable increase transcription numerous desiccation tolerance-related genes, including synthesis trehalose transference...
2‐oxoglutarate (2‐OG) is a central metabolite that acts as signaling molecule informing about the status of carbon/nitrogen balance cell. In recent years, some transcriptional regulators and even two‐component systems have been described 2‐OG sensors. nitrogen‐fixing cyanobacterium Anabaena sp. PCC 7120, two master regulators, NtcA FurA, are deeply involved in regulation nitrogen metabolism. Both them show complex intertwined regulatory circuit to achieve suitable fixation. this work, found...
Abstract Lindane (γ‐HCH) is an organochlorine pesticide that causes huge environmental concerns worldwide due to its recalcitrance and toxicity. The use of the cyanobacterium Anabaena sp. PCC 7120 in aquatic lindane bioremediation has been suggested but information relative this process scarce. In present work, data growth, pigment composition, photosynthetic/respiration rate, oxidative stress response presence at solubility limit water are shown. addition, degradation experiments revealed...
FurC (PerR, Peroxide Response Regulator) from Anabaena sp. PCC 7120 (also known as Nostoc 7120) is a master regulator engaged in the modulation of relevant processes including response to oxidative stress, photosynthesis and nitrogen fixation. Previous differential gene expression analysis furC -overexpressing strain (EB2770FurC) allowed inference putative DNA-binding consensus sequence. In present work, more data concerning regulon protein were obtained through searching FurC-box whole...
Cyanobacteria are able to tolerate, and even metabolize, moderate doses of organochlorine pesticides, such as lindane (γ-hexachlorocyclohexane), one the most persistent widely used in recent decades. Previous work showed that Microcystis aeruginosa PCC 7806 degrades that, presence pesticide, microcystin synthesis is enhanced. In this work, using silico approaches, we have identified M. putative homologues lin genes, involved degradation Sphingobium japonicum UT26S. Real-time RT-PCR assays...
FurA is a multifunctional regulator in cyanobacteria that contains five cysteines, four of them arranged into two CXXC motifs. Lack structural zinc ion enables to develop disulfide reductase activity. In vivo, displays several redox isoforms, and the oxidation state its cysteines determines activity as ability bind different metabolites. Because relationship between control genes involved oxidative stress defense photosynthetic metabolism, we sought investigate role type m thioredoxin TrxA...