Diaphragma juglandis fructus is the dry wooden diaphragm inside walnuts and a byproduct in food processing of walnut kernels. The purpose our research to enrich information on compounds further discover exploit its potential nutritional value. In this study, new quali-quantitative analytical approaches were developed identify determine bioactive fructus. Two-hundred compounds, including hydrolyzable tannins, flavonoids, phenolic acids, quinones, identified by UHPLC-Q-Orbitrap HRMS, more than...

Five new neo-clerodane diterpenoid alkaloids, named scutebarbatine G (1), 6,7-di-O-nicotinoylscutebarbatine (2), 6-O-nicotinoyl-7-O-acetylscutebarbatine (3), H (4) and 7-O-nicotinoylscutebarbatine (5) were isolated from the whole plant of Scutellaria barbata D. DON. Their structures elucidated by spectroscopic methods including extensive 1D 2D NMR analyses. In vitro, compounds 1—5 showed significant cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral...

Two new alkaloids, named suspensine A (1) and (−)-7′-O-methylegenine (2), along with two known (−)-egenine (3) (−)-bicuculline (4), were isolated from the ethanolic extract of fruits Forsythia suspensa. Their structures established by means chemical methods spectroscopic analyses. In vitro, four alkaloids showed anti-inflammatory activities, inhibition rates release β-glucuronidase polymorphonuclear leukocytes rats being in range 34.8 % – 39.6 at 10 μM.

Two new sesquiterpenoids, lyratol C (1) and D (2), together with two known dehydrovomifoliol (3) blumenol A (4), were isolated from the whole plant of Solanum lyratum. Their structures established by spectroscopic analyses. In vitro, four compounds showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, HT29 colorectal carcinoma cells, gave IC50 values in range 3.7—8.1 μM.

Four new ENT-clerodane diterpenoids were isolated from the whole plant of Scutellaria barbata D. Don. (Labiatae). Their structures elucidated by chemical methods and spectral analyses. in vitro, four compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, HT29 colorectal carcinoma cells), gave IC50 values range 3.1-7.2 microM.

Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines I—L (1—4), were isolated from the whole plant of Scutellaria barbata D. DON. Their structures established on basis detailed spectral analyses. In vitro, four compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), gave IC50 values in range 3.2—8.3 μM.

Six new neo-clerodane diterpenoid alkaloids, named scutehenanines A−D (1, 4, 5, 6), 6-O-acetylscutehenanine A (2), and 6-O-(2-carbonyl-3-methylbutanoyl)scutehenanine (3), were isolated from the whole plant of Scutellaria barbata. Their structures established on basis detailed physical data analyses. In vitro, six compounds showed cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, HT29 colorectal carcinoma cells) gave IC50 values in...

Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines C-F (1-4), were isolated from the whole plants of Scutellaria barbata D. DON. Their structures elucidated by spectral analyses (UV, IR, FAB-MS, 1D-NMR and 2D-NMR). In vitro, compounds 1-4 showed significant cytotoxic activities against three human cancer cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, HT29 colorectal carcinoma cells, gave IC(50) values in range 3.9-7.8 muM.

Five new compounds, named guangsangons A (1), B (5), C (6), D (7), and E (8), along with four known albafuran (2), kuwanon X (3), P (4), Y (9) were isolated from Morus macroura Miq.. Their structures determined by means of spectroscopic analyses chemical methods. These compounds regarded biogenetically as Diels-Al-der type adducts, 1H-NMR variable temperature experience suggested that they all existed an equilibrium mixture conformational isomers in solution. Compounds 1-3 5-9 showed good...

Fractionation of the ethanolic extract stem bark Morus macroura resulted in isolation four new Diels-Alder type adducts, named guangsangons K--N (1, 2, 5, 6), together with two known compounds, mulberrofuran G (3) and K (4). Their structures were determined on basis spectroscopic analyses chemical methods. Furthermore, by means (1)H-NMR variable temperature experiments Cotton curves circular dichroism (CD) spectra, stereochemistry compounds was elucidated. The isolated showed good activity...

Abstract Two new norditerpenoid alkaloids, named scutebarbatines M–N (1 and 2), were isolated from the whole plant of Scutellaria barbata D. Don. Their structures established on basis detailed spectral analyses. In vitro, two compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma HT29 colorectal cells), gave IC50 values in range 3.5–6.3 µM. Keywords: Labiataenorditerpenoid alkaloidscutebarbatine M–Ncytotoxic...

Two new neo-clerodane diterpenoid alkaloids, scutebarbatine O (1) and 6-O-nicotinoylscutebarbatine G (2), were isolated from the whole plant of Scutellaria barbata. Their structures elucidated by spectroscopic methods including extensive 1D 2D NMR analyses. In vitro, compounds 1 2 showed cytotoxic activities against three human tumor cell lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, HT29 colorectal carcinoma cells, with IC50 values in range 2.1–5.7 μM.

Two new ursane-type triterpenes, named as 3β, 19α, 23, 24-tetrahydroxyurs-12-en-28-oic acid (1) and 2β, (2), together with two known triterpenoids, 3-oxo-urs-12-ene-27, 28-dioic (3) quinovic acid-3-β-rhamnopyranoside (4), were isolated from the stems (with barks) of Nauclea officinalis. The structures 1 2 determined by combined use single-crystal X-ray diffraction spectroscopic data analysis. inhibitory activities on nitric oxide (NO) production induced lipopolysaccharide in mouse macrophage...

In our continuing effort to discover more new cytotoxic sesquiterpenoids from Solanum lyratum, one eudesmane-type sesquiterpenoid (1, 3-keto-eudesm-9β,11-diol, named lyratol G), together with known (2, 1β-hydroxy-1,2-dihydro-α-santonin), was obtained. The structure of the elucidated on basis integrated spectroscopic techniques, mainly HR-FAB-MS, 1D and 2D NMR (1H–1H COSY, HMQC, HMBC ROESY). vitro, two were found exhibit significant cytotoxicity against three cancer cell lines (P-388, HONE-1...

AbstractTwo new neo-clerodane diterpenoids, named scutestrigillosins D and E (1 2), were isolated from the whole plant Scutellaria strigillosa. Their structures established on basis of detailed physical data analyses. In vitro, two compounds exhibited cytotoxic activities against four tumor cell lines (HONE-1, P-388, MCF7, HT29), gave IC50 values in range 3.4–8.9 μΜ.Keywords: strigillosaLabiataeneo-clerodane diterpenoidscutestrigillosins D–Ecytotoxic activity AcknowledgementsThe authors are...