A5062630990- Plant-Microbe Interactions and Immunity
- Plant and Fungal Interactions Research
- Plant Pathogens and Fungal Diseases
- Fungal and yeast genetics research
- Extracellular vesicles in disease
- Fungal Infections and Studies
- Plant pathogens and resistance mechanisms
- Toxin Mechanisms and Immunotoxins
- Plant Disease Resistance and Genetics
- Studies on Chitinases and Chitosanases
- Histone Deacetylase Inhibitors Research
- Mobile Learning in Education
- Phytochemical compounds biological activities
- Mycotoxins in Agriculture and Food
- Forest Insect Ecology and Management
- Child Development and Digital Technology
- Plant Reproductive Biology
- Molecular Biology Techniques and Applications
- Plant Gene Expression Analysis
- Immunodeficiency and Autoimmune Disorders
- Plant Virus Research Studies
- CRISPR and Genetic Engineering
- Pediatric health and respiratory diseases
- Congenital Ear and Nasal Anomalies
- Literacy, Media, and Education
Cluster of Excellence on Plant Sciences
2019-2024
Heinrich Heine University Düsseldorf
2019-2024
Seoul National University
2014-2020
ENT and Allergy
2020
Imperial College London
2018-2019
Dankook University
2008
The biotrophic fungal pathogen Blumeria graminis causes the powdery mildew disease of cereals and grasses. We present first crystal structure a B. effector pathogenicity (CSEP0064/BEC1054), demonstrating it has ribonuclease (RNase)-like fold. This is part group RNase-like proteins (termed RALPHs) which comprise largest set secreted candidates within genomes. Their exceptional abundance suggests they play crucial functions during pathogenesis. show that transgenic expression RALPH...
Abstract Pathogens utilize multiple types of effectors to modulate plant immunity. Although many apoplastic and cytoplasmic have been reported, nuclear not well characterized in fungal pathogens. Here, we characterize two the rice blast pathogen Magnaporthe oryzae . Both are secreted via biotrophic interfacial complex, translocated into nuclei initially penetrated surrounding cells, reprogram expression immunity-associated genes by binding on effector elements rice. Their transgenic causes...
Extracellular vesicles (EVs) can transfer diverse RNA cargo for intercellular communication. EV-associated RNAs have been found in fungi and were proposed to be relevant pathogenesis animal hosts. In plant-pathogen interactions, small are exchanged a cross-kingdom RNAi warfare EVs considered delivery mechanism. To extend the search molecules involved communication, we characterised repertoire of mRNAs secreted by maize smut pathogen, Ustilago maydis. For this initial survey, examined...
The rice blast (fungal pathogen: Magnaporthe oryzae and host: Oryza sativa) is one of the most important model pathosystems for understanding plant-microbe interactions. Although both genome sequences were published as first cases pathogen host, only a few in planta transcriptome data during infection are available. Due to technical difficulties, previously reported fungal not highly qualified comprehensively profile expression genes infection. Here, we report high-quality transcriptomes M....
Summary Histone acetylation has been established as a principal epigenetic regulatory mechanism in eukaryotes. Sas3, histone acetyltransferase belonging to the largest family of acetyltransferase, MYST, is catalytic subunit conserved complex. To date, functions Sas3 and its orthologues have extensively studied yeast, humans flies relation global transcriptional regulation. However, precise impact on development pathogenicity fungal plant pathogens yet be elucidated. Considering importance...
Acetylation of histone H3 lysine 56 (H3K56) by the fungal-specific acetyltransferase Rtt109 plays important roles in maintaining genome integrity and surviving DNA damage. Here, we investigated implications Rtt109-mediated response to damage on development pathogenesis rice blast fungus Magnaporthe oryzae (anamorph: Pyricularia oryzae). The ortholog M. (MoRtt109) was found via sequence homology its functionality confirmed phenotypic complementation Saccharomyces cerevisiae deletion strain....
Extracellular vesicles (EVs) can transfer diverse RNA cargo for intercellular signalling. EV-associated RNAs have been found in fungi and were proposed to be relevant pathogenesis animal hosts. In plant-pathogen interactions, small are exchanged a cross-kingdom RNAi warfare EVs considered delivery mechanism. To extend the search molecules involved plants-pathogen communication, we characterised repertoire of mRNAs secreted by maize smut pathogen, Ustilago maydis. For this initial survey,...
Fungal pathogens execute well-defined infection programs that are intensively regulated at the posttranscriptional level.RNA biology determines precise timing and subcellular expression of encoded proteins.This temporal coordination is especially vital for membrane trafficking in order to synchronize intracellular organelle network.This includes vacuole maturation, intra-and extracellular vesicle (EV) transport, protein entry into mitochondria, peroxisomes, ER.Here, we explore intimate link...
ABSTRACT RNA interference (RNAi) is a crucial mechanism that can contribute to immunity against infectious microbes through the action of DICER-LIKE (DCL) and ARGONAUTE (AGO) proteins. In case fungal pathogen Botrytis cinerea oomycete Hyaloperonospora arabidopsidis , plant DCL AGO proteins have proven roles as negative regulators immunity, suggesting functional specialization these To address this aspect in broader taxonomic context, we characterized colonization pattern an informative set...
Abstract RNA interference (RNAi) is a crucial mechanism in immunity against infectious microbes through the action of DICER‐LIKE (DCL) and ARGONAUTE (AGO) proteins. In case taxonomically diverse fungal pathogen Botrytis cinerea oomycete Hyaloperonospora arabidopsidis , plant DCL AGO proteins have proven roles as negative regulators immunity, suggesting functional specialization these To address this aspect broader taxonomic context, we characterized colonization pattern an informative set...
Abstract In recent years, extracellular vesicles (EVs) have emerged as novel key players in plant–microbe interactions. While it is immensely useful to draw on the established “minimal information for studies of vesicles” (MISEV) guidelines and precedents mammalian systems, working with plants their associated microbes poses specific challenges. To navigate researchers through these obstacles, we offer detailed step‐by‐step suggestions those embarking EV research context The advice based...
Membrane-coupled RNA transport is an emerging theme in fungal biology. This review focuses on the cargo and mechanistic details of via two inter-related sets organelles: endosomes extracellular vesicles for intra- intercellular transfer. Simultaneous translation messenger RNAs (mRNAs) surface shuttling a conserved process pertinent to highly polarised eukaryotic cells, such as hyphae or neurons. Here we detail endosomal mRNA machinery components targets core RNA-binding protein Rrm4....
ABSTRACT The biotrophic fungal pathogen Blumeria graminis causes the powdery mildew disease of cereals and grasses. Proteins with a predicted ribonuclease (RNase)-like fold (termed RALPHs) comprise largest set secreted effector candidates within B. f. sp. hordei genome. Their exceptional abundance suggests they play crucial functions during pathogenesis. We show that transgenic expression RALPH CSEP0064/BEC1054 increases susceptibility to infection in monocotyledenous dicotyledonous plants....