Context: Depressed mood is frequently reported by individuals who have sustained cerebral concussion but little known about the nature of this alteration in state.Objective: To investigate whether symptoms depression reflect an ongoing pathophysiological change following concussion.Design: Cohort study with male athletes using functional and structural neuroimaging.Setting: Hospital laboratory imaging facility.Participants: Fifty-six without were divided into (1) a no symptom, concussed...

Abstract The ability to orientate within familiar environments relies on the formation and use of a mental representation environment, namely cognitive map. Neuropsychological neuroimaging studies suggest that retrosplenial hippocampal brain regions are involved in topographical orientation. We combined functional magnetic resonance imaging with virtual‐reality paradigm investigate interaction hippocampus cortex during utilization maps by human subjects. found anterior is map, while...

Symptoms persisting beyond the acute phase (>2 months) after a mild traumatic brain injury (MTBI) are often reported, but their origin remains controversial. Some investigators evoke dysfunctional cerebral mechanisms, while others ascribe them to psychological consequences of injury. We address this controversy by exploring possible dysfunction with functional magnetic resonance imaging (fMRI) and event-related potentials (ERP) in group patients during post-acute phase. Fourteen MTBI...

Significance Using functional MRI we examined the unconscious influence of early experience on later brain outcomes. Internationally adopted (IA) children (aged 9–17 years), who were completely separated from their birth language (Chinese) at 12.8 mo age, average, displayed activation to Chinese linguistic elements that precisely matched native speakers, despite fact IA had no subsequent exposure and conscious recollection language. Importantly, differed monolingual French speakers with...

Mild traumatic brain injury (mTBI) is typically followed by various postconcussive symptoms (PCS), including headache, depression, and cognitive deficits. In 15–25% of cases, PCS persists beyond the usual 3-month recovery period, interfering with activities daily living responding poorly to pharmacotherapy. We tested safety, tolerability, efficacy repetitive transcranial magnetic stimulation (rTMS) over left dorsolateral prefrontal cortex (DLPFC) for alleviating PCS. Fifteen eligible...

Due to the ubiquitous nature of language in environment infants, how it affects anatomical structure brain system over lifespan is not well understood. In this study, we investigated effects early experience on adult by examining features individuals born deaf with typical or restricted childhood. Twenty-two adults whose primary was American Sign Language and were first immersed at ages ranging from birth 14 y participated. The control group 21 hearing non-signers. We acquired T1-weighted...

Mild traumatic brain injury (mTBI) in contact sport is a problem of such magnitude that improved approaches to diagnosis, investigation and management are urgent. Concussion has traditionally been described as transient, fully reversible, cerebral dysfunction. However, this seemingly 'mild' sometimes results long-lasting disabling post-concussion symptoms (PCS) abnormal neuropsychological profiles characteristic frontal and/or temporal lobe At present, the pathological changes following...

Objective: To examine functional brain activation patterns before and after postconcussive symptoms (PCS) resolution. Design: Prospective serial study with male athletes using magnetic resonance imaging (fMRI). Setting: Hospital laboratory facility. Participants: 9 symptomatic concussed who experienced persisting PCS at least 1 month postinjury 6 healthy athletes. Interventions: All filled out a checklist underwent an fMRI session during which they performed working-memory task. Main outcome...

Mild traumatic brain injury (MTBI), often referred to as concussion when it occurs in sports, produces persistent cognitive problems at least 15% of patients. Unfortunately, conventional neuropsychological tests usually yield results within normal limits this population. The main objective event-related potential (ERP) study was understand functioning during the performance a working memory (WM) task patients who have sustained an MTBI, mostly due motor vehicle accident or sports concussion....

Abstract Early experiences may establish a foundation for later learning, however, influences of early language experience on neural processing are unknown. We investigated whether maintenance templates from subsequent processing. Using fMRI, we scanned the following three groups performing French phonological working memory (PWM) task: (1) monolingual children; (2) children adopted China before age 3 who discontinued Chinese and spoke only French; (3) Chinese-speaking learned as second but...

Mild traumatic brain injury (mTBI) is a common cause of in youth athletes. Much what known about the sequelae mTBI yielded from adult literature, and it appears that mainly those with persistent post-injury symptoms who have ongoing cognitive neural abnormalities. However, most studies employed single-task paradigms, which may not be challenging enough to uncover subtle deficits. We sought examine correlates dual-task performance male athletes aged 9-15 years using functional neuroimaging...

Multiple sclerosis (MS) patients have central nervous system (CNS) lesions that may impede cognitive and sensorimotor function. Few rehabilitative therapies are available.The objective of this paper is to study effects noninvasive tongue stimulation using the Portable Neuromodulation Stimulator (PoNS™) combined with intensive physical rehabilitation on working memory, gait, balance concomitant changes in brain.Fourteen MS patients, seven each an active a sham group, participated....

Mild traumatic brain injury (mTBI) is common in youth, especially those who participate sport. Recent investigations from our group have shown that asymptomatic children and adolescents with mTBI continue to exhibit alterations neural activity cognitive performance compared without a history of mTBI. This an intriguing finding, given current return-to-learn return-to-play protocols rely predominately on subjective symptom reports, which may not be sensitive enough detect subtle...

Abstract Objectives This study aimed to investigate changes in three intrinsic functional connectivity networks (IFCNs; default mode network [DMN], salience [SN], and task‐positive [TPN]) individuals who had sustained a mild traumatic brain injury (mTBI). Methods Resting‐state magnetic resonance imaging (rs‐fMRI) data were acquired from 27 mTBI patients with persistent postconcussive symptoms, along 26 age‐ sex‐matched controls. These recruited Level‐1 trauma center, at least 3 months after...