A5011640364- Hemoglobinopathies and Related Disorders
- Blood donation and transfusion practices
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Blood transfusion and management
- Periodontal Regeneration and Treatments
- Blood groups and transfusion
- Botulinum Toxin and Related Neurological Disorders
- Genital Health and Disease
- Pancreatic function and diabetes
- Nerve injury and regeneration
- SARS-CoV-2 detection and testing
- Blood Coagulation and Thrombosis Mechanisms
- Mesenchymal stem cell research
- COVID-19 Clinical Research Studies
- Polyamine Metabolism and Applications
- Cancer, Hypoxia, and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Hereditary Neurological Disorders
- Neonatal Health and Biochemistry
- Neurotransmitter Receptor Influence on Behavior
- Inflammatory Biomarkers in Disease Prognosis
Azienda Sanitaria Unità Locale di Reggio Emilia
2022-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2023
University of Modena and Reggio Emilia
1986-2023
Various ocular surface diseases are treated with blood-derived eye drops. Their use has been introduced in clinical practice because of their metabolite and growth factor content, which promotes regeneration. Blood-based drops can be prepared from different sources (i.e., whole blood or platelet apheresis donation), as well protocols (e.g., dilutions freeze/thaw cycles). This variability hampers the standardization and, consequently, evaluation efficacy. Detailing sharing methodological...
Cryopreservation affects platelets' function, questioning their use for cancer patients. We aimed to investigate the biochemical events that occur over time after thawing optimize transfusion timing and evaluate effect of platelet supernatants on tumor cell behavior in vitro. compared fresh (Fresh-PLT) with Cryopreserved platelets (Cryo-PLT) at 1 h, 3 h 6 thawing. MCF-7 HL-60 cells were cultured Fresh- or Cryo-PLT proliferation, migration, PLT-cell adhesion. noticed a significant impairment...
Plasmapheresis donation is considered safe and well tolerated, although long-term effects need to be clarified. The volumes of anticoagulant (ACD-A) used are variable depend primarily on hematocrit (HCT), total blood processed, amount plasma collected, donor characteristics. To elucidate the effect unit weight setting plasmapheresis efficiency ACD-A distribution, we enrolled male donors undergoing a controlled apheresis process donating 700 g 720 in two different sessions. In parallel,...
Intraoperative cell salvage reduces the need for allogeneic blood transfusion in complex cancer surgery, but concerns about possibility of it re-infusing cells have hindered its application oncology. We monitored presence on patient-salvaged by means flow cytometry; next, we simulated salvage, followed leucodepletion and irradiation contaminated with a known amount EpCAM-expressing cells, assessing also residual proliferation as well quality salvaged red concentrates (RBCs). observed...
To investigate the association between biochemical and blood parameters collected before pandemic in a large cohort of Italian donors with risk infection severe disease. We also focused on differences pre- post-Omicron spread Italy (i.e., post-January 01, 2022) observed associations. conducted an observational study 13750 was using data archived up to 5 years pandemic. A t-test or chi-squared test used compare groups. Hazard ratios 95% confidence intervals for SARS-CoV-2 disease were...
Various ocular surface diseases are treated with blood-derived eye drops. Their use has been introduced in clinical practice because of their metabolite and growth factor content, which promotes regeneration. Blood-based drops can be prepared from different sources (i.e., whole blood or platelet apheresis donation), as well protocols (e.g., dilutions freeze/thaw cycles). This variability hampers the standardization and, consequently, evaluation efficacy. Detailing sharing methodological...